N-cyclohexyl-palmitoyl amide | 17427-96-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-cyclohexyl-palmitoyl amide
• 英文别名: N-cyclohexylhexadecanamide；N-cyclohexyl-palmitamide；N-Cyclohexyl-palmitinamid；N-Cyclohexyl-palmitamid；N-Cyclohexyl-palmitamid
• CAS: 17427-96-2
• 化学式: C₂₂H₄₃NO
• 分子量: 337.59
• InChiKey: OXNIVLAQPVUFDE-UHFFFAOYSA-N

物化性质

• 熔点：
  94-95 °C
• 沸点：
  480.7±12.0 °C(Predicted)
• 密度：
  0.89±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  24
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  棕榈酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 生成 N-cyclohexyl-palmitoyl amide
  参考文献：
  名称：

  Monitored aminolysis of 3-acylthiazolidine-2-thione : A new convenient synthesis of amide

  摘要：

  DOI：

  10.1016/s0040-4039(00)71520-6

文献信息

• Mesoporous silica MCM-41 as a highly active, recoverable and reusable catalyst for direct amidation of fatty acids and long-chain amines
  作者：Kenichi Komura、Yu Nakano、Mamoru Koketsu

  DOI：10.1039/c0gc00673d

  日期：——

  Direct amidation of fatty acids with long-chain amines was successfully performed by mesoporous silica MCM-41, which showed the highest catalytic activity among other used homo- and heterogeneous catalysts. It was found that MCM-41 can be easily recovered from the reaction mixture followed by simple calcination treatment and reused without loss of its catalytic activity.

  直接酰胺化 脂肪酸 长链 胺类 由介孔成功完成 硅石 MCM-41，在其他同质和异质中显示出最高的催化活性 催化剂。发现可以容易地从反应混合物中回收MCM-41，然后简单地将其回收。煅烧 处理并重复使用，而不会损失其催化活性。
• A catalyst system for the formation of amides by reaction of carboxylic acids with blocked isocyanates
  作者：R. Gertzmann、C. Gürtler

  DOI：10.1016/j.tetlet.2005.07.156

  日期：2005.9

  A catalyst for the reaction of blocked isocyanates (blocking agent diisopropylamine and dimethyl pyrazole) and carboxylic acids was identified. Magnesium and in some instances calcium salts proved to be highly active as catalyst. This reaction gives amides in quantitative yield and excellent selectivity and is suitable for coating and general chemical purposes.

  鉴定了用于封端的异氰酸酯（封端剂二异丙胺和二甲基吡唑）和羧酸反应的催化剂。镁和某些情况下的钙盐被证明具有很高的催化活性。该反应以定量收率和优异的选择性产生酰胺，并且适合于涂料和一般化学目的。
• New endocannabinoid-like compounds and their use
  申请人：RESEARCH & INNOVATION SOC. COOP. A R.L.

  公开号：EP1900365A2

  公开（公告）日：2008-03-19

  The present invention describes compounds deriving from chemical reactions between saturated or monounsaturated acyl derivatives and primary amines or primary alcohols that display specific cannabinoid-like pharmacological activity without exhibiting the central unwanted side effects typical of synthetic cannabinoids or endocannabinoids acting on central cannabinoid (CB1) receptors. These compounds, having this pharmacological activity, may be utilised to prevent or to treat pathological conditions and diseases in mammals, including human subjects, that may undergo a clinical improvement upon their administration.

  本发明描述了由饱和或单不饱和酰基衍生物与伯胺或伯醇之间的化学反应所产生 的化合物，这些化合物显示出类似大麻素的特殊药理活性，而不会表现出合成大麻 素或作用于中枢大麻素（CB1）受体的内源性大麻素所特有的中枢性不良副作用。这些具有这种药理活性的化合物可用于预防或治疗哺乳动物（包括人类）的病理状况和疾病，服用后可改善临床症状。
• New Compounds - Substituted Amides
  作者：C Bowen、L Smith

  DOI：10.1021/ja01869a601

  日期：1940.12
• Nagao, Yoshimitsu; Seno, Kaoru; Kawabata, Kohji, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 7, p. 2687 - 2699
  作者：Nagao, Yoshimitsu、Seno, Kaoru、Kawabata, Kohji、Miyasaka, Tadao、Takao, Sachiko、Fujita, Eiichi

  DOI：——

  日期：——