4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid, (2S,4R,6E)- | 1821736-49-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid, (2S,4R,6E)-
• 英文别名: (E,2S,4R)-4-methyl-2-(methylamino)-3-oxooct-6-enoic acid
• CAS: 1821736-49-5
• 化学式: C₁₀H₁₇NO₃
• 分子量: 199.25
• InChiKey: RNSQZHRCLLLRKC-VWFQECGMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Use of [gamma-hydroxy-N-methyl-leucine9] cyclosporin a for hair growth
  申请人：——

  公开号：US20020165133A1

  公开（公告）日：2002-11-07

  The present invention discloses a hair growth promoter comprising [&ggr;-hydroxy-N-methyl-L-leucine 9 ] cyclosporin A, in which a hydroxy group is added to a &ggr; carbon of N-methyl-L-leucine at No. 9 position in cyclosporin A by metabolic action of a microorganism, as an active ingredient.

  本发明公开了一种毛发生长促进剂，它包含[&ggr;-羟基-N-甲基-L-亮氨酸 9 ]环孢素A，其中通过微生物的代谢作用，在环孢素A中N-甲基-L-亮氨酸9号位置的&ggr;碳上添加羟基作为活性成分。
• Use of nonimmunosuppressive [$g(g)-hydroxy-n-methyl-l-leucine4]cyclosporin derivatives for treating hair loss
  申请人：——

  公开号：US20040161399A1

  公开（公告）日：2004-08-19

  The present invention discloses a hair growth promoting agent comprising a cyclosporin derivative having an excellent hair growth stimulating ability with little immunosuppressive effect as an active ingredient. In accordance with the invention, there is provided a hair growth promoting agent comprising a cyclosporin derivative represented by Chemical Formula 1 below. The derivatives of the invention were prepared by derivatization of cyclosporins at the amino acid residue 4, N-methyl-L-leucine, and hair growth promoting effects thereof were examined. Such a hair growth promoting agent, comprising a cyclosporin derivative as an active ingredient, exhibits an excellent hair growth effect, while it shows very weak immunosuppressive activity, compared to unmodified cyclosporin A.

  本发明公开了一种毛发生长促进剂，其活性成分包括一种具有极佳毛发生长刺激能力且免疫抑制作用小的环孢素衍生物。根据本发明，提供了一种促进毛发生长的制剂，它包含如下化学式 1 所表示的环孢素衍生物。本发明的衍生物是通过在氨基酸残基 4 N-甲基-L-亮氨酸处对环孢素进行衍生化而制备的，并对其促进毛发生长的效果进行了研究。与未改性的环孢素 A 相比，这种以环孢素衍生物为活性成分的生发剂具有极佳的生发效果，而其免疫抑制活性非常弱。
• USE OF (GAMMA-HYDROXY-N-METHYL-L-LEUCINE9) CYCLOSPORIN A FOR HAIR GROWTH
  申请人：LG Household & Health Care Ltd.

  公开号：EP1361850A1

  公开（公告）日：2003-11-19
• EP1361850A4
  申请人：——

  公开号：EP1361850A4

  公开（公告）日：2004-08-04
• USE OF 3-POSITION CYCLOSPORIN DERIVATIVES FOR HAIR GROWTH
  申请人：LG Household & Health Care Ltd.

  公开号：EP1387660A1

  公开（公告）日：2004-02-11