N,S-diacetyl homocystein | 1031247-72-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,S-diacetyl homocystein
• 英文别名: GLN 10,035；(2S)-4-(acetylsulfanyl)-2-acetamidobutanoic acid；(2S)-2-acetamido-4-acetylsulfanylbutanoic acid
• CAS: 1031247-72-9
• 化学式: C₈H₁₃NO₄S
• 分子量: 219.262
• InChiKey: IWEOCYDOKOQHMF-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  DL-蛋氨酸 在 sodium 、 乙酸酐 作用下， 以 氨 、 水 为溶剂， 生成 N,S-diacetyl homocystein
  参考文献：
  名称：

  Thiol esters of homocysteine

  摘要：

  ADT衍生物可以是自由或盐形式的，有机或矿物质基础，其中ADT衍生物包含特征基团--S--CH.sub.2 --CH.sub.2 --CH（NHR）--CO--以环状形式表示为##STR1## 其中R代表含有超过4个碳原子的酰基，当其为肉桂酰基时被取代，开放式形式为R'--S--CH --CH --CH（NHR）--C)--X--R"，其中X为氧或硫，R'和R相同或不同，并从氢和酰基基团中选择，R"为氢或取代的醇基，当X为氧时，R"至少有2个碳原子，R为较低的酰基，R'为氢。

  公开号：

  US04072703A1

文献信息

• [EN] S-NITROSOMERCAPTO COMPOUNDS AND RELATED DERIVATIVES<br/>[FR] COMPOSÉS DE S-NITROSOMERCAPTO ET DÉRIVÉS APPARENTÉS
  申请人：GALLEON PHARMACEUTICALS INC

  公开号：WO2009151744A1

  公开（公告）日：2009-12-17

  The present invention is directed to mercapto-based and S- nitrosomercapto-based SNO compounds and their derivatives, and their use in treating a lack of normal breathing control, including the treatment of apnea and hypoventilation associated with sleep, obesity, certain medicines and other medical conditions.

  本发明涉及基于巯基和S-亚硝基巯基的SNO化合物及其衍生物，以及它们在治疗正常呼吸控制缺失方面的用途，包括治疗与睡眠、肥胖、某些药物和其他医疗状况相关的呼吸暂停和低通气。
• N-acetylamino acids, related N-acetyl compounds and their topical use
  申请人：——

  公开号：US20030198656A1

  公开（公告）日：2003-10-23

  Compositions comprising N-acetylamino acids and/or related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. The N-acetylamino acid and/or related N-acetyl compound composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

  由 N-乙酰基氨基酸和/或相关 N-乙酰基化合物组成的组合物可用于缓解或改善各种美容状况和皮肤病，包括与内在老化和/或外在老化相关的皮肤、指甲和头发的变化或损伤，以及由外在因素引起的变化或损伤。N-acetylamino acid 和/或相关 N-acetyl 化合物组合物可进一步包含化妆品、药物或其他外用制剂，以增强或产生协同效应。
• N-acetyl cysteine and its topical use
  申请人：——

  公开号：US20030229141A1

  公开（公告）日：2003-12-11

  Methods to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors using compositions comprising N-acetyl-cysteine (isomeric or non-isomeric forms) and/or free acid, salt, lactone, amide or ester forms of N-acetyl-cysteine are described. The methods provided may also comprise application of a composition further containing various cosmetic, pharmaceutical or other topical agents to enhance or create synergetic effects.

  本文描述了使用包含 N-乙酰-半胱氨酸（异构体或非异构体形式）和/或 N-乙酰-半胱氨酸的游离酸、盐、内酯、酰胺或酯形式的组合物来缓解或改善各种美容状况和皮肤病的方法，包括与内在老化和/或外在老化相关的皮肤、指甲和头发的变化或损伤，以及外在因素引起的变化或损伤。所提供的方法还可包括使用进一步含有各种化妆品、药物或其他外用制剂的组合物，以增强或产生协同效应。
• S-Nitrosothiol Compounds and Related Derivatives
  申请人：Mannion James C.

  公开号：US20100105685A1

  公开（公告）日：2010-04-29

  The present invention is directed to a method of treating a lack of normal breathing control including the treatment of apnea and hypoventilation associated with sleep, obesity, certain medicines and other medical conditions. In an aspect, the invention is directed to treating disordered control of breathing by administering an composition comprising a single compound which treats lack of normal breathing. In another aspect, the invention is directed to treating disordered control of breathing by administering an composition comprising a combination of two or more compounds, at least one of which treats lack of normal breathing. In an aspect, a compound is an S-nitrosylating agent.
• US4072703A
  申请人：——

  公开号：US4072703A

  公开（公告）日：1978-02-07