4-hydroxy-3-(hydroxymethyl)benzoic acid ethylester | 868699-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-hydroxy-3-(hydroxymethyl)benzoic acid ethylester
• 英文别名: Ethyl 4-hydroxy-3-(hydroxymethyl)benzoate
• CAS: 868699-15-4
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.203
• InChiKey: URTKVOPSSKIIKF-UHFFFAOYSA-N

物化性质

• 沸点：
  342.8±12.0 °C(Predicted)
• 密度：
  1.257±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-hydroxy-3-(hydroxymethyl)benzoic acid ethylester 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以95%的产率得到ethyl 3-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxybenzoate
  参考文献：
  名称：

  The pyridinone-methide elimination

  摘要：

  醌-亚甲基消除反应是一种常见且高效的方法，常用于设计能够自我碎裂的连接剂。在这里，我们首次在吡啶环体系中演示了这种消除反应。在生理条件下，由吡啶核心、报告基和酶触发剂构建的化合物，其1,4消除反应的速度显著快于其苯核心的母体化合物。此外，基于吡啶核心的AB2自毁树枝状聚合物在通过1,6和1,4吡啶酮-亚甲基消除反应激活后，释放其两个报告基，速度同样快于类似的苯体系。与基于苯的化合物相比，基于吡啶的化合物表现出更好的水溶性。吡啶酮-亚甲基消除反应可以作为设计自我毁灭连接剂的替代工具，用于在水相环境中释放活性靶向分子。

  DOI：

  10.1039/b915265b
• 作为产物：
  描述：

  4-formyl-3-(hydroxymethyl)benzoic acid ethylester 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 4-hydroxy-3-(hydroxymethyl)benzoic acid ethylester
  参考文献：
  名称：

  [DE] PHENYLACETAMIDE
  [EN] PHENYL ACETAMIDES
  [FR] PHENYLACETAMIDES

  摘要：

  本发明涉及化合物的苯乙酰胺（I）的制备方法及其用途，用于制备用于治疗和/或预防人类和动物疾病，特别是心血管疾病的药物。

  公开号：

  WO2005103001A1

文献信息

• Phenyl Acetamides
  申请人：Harter Michael

  公开号：US20080176898A1

  公开（公告）日：2008-07-24

  The present invention relates to phenylacetamides, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, especially of cardiovascular disorders.

  本发明涉及苯乙酰胺、其制备方法以及其用于制备人和动物的药物治疗和/或预防心血管疾病等疾病的用途。
• (Ethylene, vinyl acetal) copolymers and their use in lithographic printing plate precursors
  申请人：AGFA GRAPHICS NV

  公开号：EP2933278A1

  公开（公告）日：2015-10-21

  A copolymer comprising (i) a plurality of ethylenic moieties A having a structure according to the following formula: wherein R2 and R3 independently represent hydrogen, a halogen or an optionally substituted linear, branched or cyclic alk(en)yl group, or an optionally substituted aromatic or heteroaromatic group, and (ii) a plurality of acetal moieties B having a structure according to the following formula: wherein L represents a divalent linking group; x = 0 or 1 and R1 represents an optionally substituted aromatic or heteroaromatic group including at least one hydroxyl group and optionally one or more additional substituent(s), and at least one electron withdrawing group in ortho or para position relative to the at least one hydroxyl group.

  一种共聚物，包含(i)多个具有下式结构的乙烯基分子 A： 其中 R2 和 R3 独立地代表氢、卤素或任选取代的直链、支链或环状烷（烯）基，或任选取代的芳香族或杂芳香族基团，以及 (ii) 具有下式结构的多个缩醛分子 B： 其中 L 代表二价连接基团；x = 0 或 1，R1 代表任选取代的芳香族或杂芳香族基团，包括至少一个羟基和任选一个或多个附加取代基，以及至少一个相对于至少一个羟基位于正位或对位的取电子基团。
• (ETHYLENE, VINYL ACETAL) COPOLYMERS AND THEIR USE IN LITHOGRAPHIC PRINTING PLATE PRECURSORS
  申请人：AGFA GRAPHICS NV

  公开号：US20170101496A1

  公开（公告）日：2017-04-13

  A copolymer includes (i) a plurality of ethylenic moieties A having a structure according to the following formula: wherein R2 and R3 independently represent hydrogen, a halogen or an optionally substituted linear, branched or cyclic alk(en)yl group, or an optionally substituted aromatic or heteroaromatic group, and (ii) a plurality of acetal moieties B having a structure according to the following formula: wherein L represents a divalent linking group; x=0 or 1 and R1 represents an optionally substituted aromatic or heteroaromatic group including at least one hydroxyl group and optionally one or more additional substituent(s), and at least one electron withdrawing group in ortho or para position relative to the at least one hydroxyl group.
• ANTIVIRAL WIPER
  申请人：FUJIFILM Corporation

  公开号：US20210171883A1

  公开（公告）日：2021-06-10

  An object of the present invention is to provide an antiviral wiper having excellent antiviral activity and excellent storage stability. The antiviral wiper according to an embodiment of the present invention is an antiviral wiper having a base fabric and a liquid agent with which the base fabric is impregnated. The content of a cellulosic fiber in the base fabric is equal to or lower than 70% by mass with respect to the total mass of fibers constituting the base fabric. The liquid agent is alkaline and contains a compound X having a pKa of 7.0 to 15.0 and a solvent containing at least an alcohol, and the content of the alcohol is 40% to 100% by mass with respect to the total mass of the solvent.
• [EN] (ETHYLENE, VINYL ACETAL) COPOLYMERS AND THEIR USE IN LITHOGRAPHIC PRINTING PLATE PRECURSORS<br/>[FR] COPOLYMÈRES (ÉTHYLÈNE, ACÉTAL VINYLIQUE) ET LEUR UTILISATION DANS DES PRÉCURSEURS DE PLAQUE D'IMPRESSION LITHOGRAPHIQUE
  申请人：AGFA GRAPHICS NV

  公开号：WO2015158566A1

  公开（公告）日：2015-10-22

  A copolymer comprising (i) a plurality of ethylenic moieties A having a structure according to the following formula: wherein R2 and R3 independently represent hydrogen, a halogen or an optionally substituted linear, branched or cyclic alk(en)yl group, or an optionally substituted aromatic or heteroaromatic group, and (ii) a plurality of acetal moieties B having a structure according to the following formula: wherein L represents a divalent linking group; x = 0 or 1 and R1 represents an optionally substituted aromatic or heteroaromatic group including at least one hydroxyl group and optionally one or more additional substituent(s), and at least one electron 1 withdrawing group in ortho or para position relative to the at least one hydroxyl group.