4-ethoxy-3-hydroxy-4-oxobutanoic acid | 71901-42-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 4-ethoxy-3-hydroxy-4-oxobutanoic acid
• 英文别名: malic acid 1-ethyl ester；ethyl malate；malic acid monoethyl ester；Aepfelsaeure-monoaethylester；Monoaethyl-DL-malat；Butanedioic acid, 2-hydroxy-, 1-ethyl ester
• CAS: 71901-42-3
• 化学式: C₆H₁₀O₅
• 分子量: 162.142
• InChiKey: FHHFKGGCXNOIAY-UHFFFAOYSA-N

物化性质

• 沸点：
  125-130 °C(Press: 17 Torr)
• 密度：
  1.1215 g/cm3(Temp: 38 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-ethoxy-3-hydroxy-4-oxobutanoic acid 在 水 、 sodium hydroxide 作用下， 反应 0.01h， 以95%的产率得到sodium malate
  参考文献：
  名称：

  Process for preparing hyperpolarized substrates and method for MRI

  摘要：

  本发明一般涉及一种用于制备水溶液的过程，该水溶液中的超极化分子可用于体内MR诊断成像，用作MRI对比剂，用于生产人体或非人类动物身体器官、区域或组织的诊断MR图像的调查方法。

  公开号：

  US09694090B2
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 1,4-二氧六环 、 selenium(IV) oxide 作用下， 生成 4-ethoxy-3-hydroxy-4-oxobutanoic acid
  参考文献：
  名称：

  205.二氧化硒，一种新的氧化剂。第五部分进一步的氧化

  摘要：

  DOI：

  10.1039/jr9350000901

文献信息

• Boric Acid Catalyzed Chemoselective Esterification of α-Hydroxycarboxylic Acids
  作者：Todd A. Houston、Brendan L. Wilkinson、Joanne T. Blanchfield

  DOI：10.1021/ol036123g

  日期：2004.3.1

  Boric acid catalyzes the selective esterification of alpha-hydroxycarboxylic acids without causing significant esterification to occur with other carboxylic acids. The procedure is simple, high-yielding, and applicable to the esterification of alpha-hydroxy carboxylates in the presence of other carboxylic acids including beta-hydroxyacids within the same molecule. [reaction: see text]

  硼酸催化α-羟基羧酸的选择性酯化反应，而不会引起与其他羧酸的明显酯化反应。该过程简单，高产率，并且适用于在同一分子内存在其他羧酸（包括β-羟基酸）的情况下对α-羟基羧酸酯进行酯化。[反应：看文字]
• Glucagon antagonists/inverse agonists
  申请人：——

  公开号：US20020143186A1

  公开（公告）日：2002-10-03

  A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism, such as dyslipidemia, and obesity.

  一种新型化合物类别，其作用是拮抗胰高血糖素激素对胰高血糖素受体的作用。由于这些化合物对胰高血糖素受体的拮抗作用，这些化合物可能适用于治疗和/或预防任何胰高血糖素拮抗作用有益的疾病和疾病，如高血糖症、1型糖尿病、2型糖尿病、脂质代谢紊乱疾病，如血脂异常和肥胖症。
• RAPIDLY CURING CYANOACRYLATES AS ADHESIVES
  申请人：Swords Noeleen

  公开号：US20100029978A1

  公开（公告）日：2010-02-04

  The present invention relates to a polymerizable adhesive composition which comprises, at least as one constituent, a cyanacrylate component and which requires a comparitively short time for curing when used on surfaces. The present invention therefore also includes a method for the production of the cyanacrylate component described above, and the cyanacrylate component as such.

  本发明涉及一种聚合粘合剂组成物，至少包括一种氰基丙烯酸酯组分，并在表面使用时需要相对较短的固化时间。因此，本发明还包括上述氰基丙烯酸酯组分的制备方法以及氰基丙烯酸酯组分本身。
• [EN] SELECTIVE HYDROGENATION OF FUNCTIONAL GROUPS IN SUBSTRATES AND PARTIALLY HYDROGENATED FATTY ACIDS AND FATTY ACID DERIVATIVES<br/>[FR] HYDROGENATION SELECTIVE DE GROUPES FONCTIONNELS DANS DES SUBSTRATS ET ACIDES GRAS PARTIELLEMENT HYDROGENES ET DERIVES D'ACIDES GRAS
  申请人：HAERROED RES AB

  公开号：WO2005095306A1

  公开（公告）日：2005-10-13

  Process for the hydrogenation of functional groups in hydrogenatable substrates, wherein hydrogen gas is mixed with the substrate and a solvent, the mixture is brought into contact with a catalyst. The hydrogenation is carried out under process conditions which are adapted to the activity of the catalyst used, wherein the temperature is sufficiently low, the substrate concentration is sufficiently high and the diffusivity is sufficiently high to provide a selective hydrogenation of the functional group having a higher reactivity than one which has a lower reactivity. The functional groups can for example comprise different C=C-groups in substrates in the form of lipids, primarily fatty acids and fatty acid derivatives, such as triglycerides and methyl fatty acids. Partially-hydrogenated fatty acids/fatty acid derivatives can hereby be obtained, which possess a low content of trans-fatty acid content as well as high selectivity in the form of SLf number and Sao-number.

  氢化可氢化底物中的官能团的过程，其中氢气与底物和溶剂混合，将混合物与催化剂接触。氢化在适应所使用催化剂的活性的过程条件下进行，其中温度足够低，底物浓度足够高且扩散性足够高，以提供具有较高反应性的官能团的选择性氢化，而不是具有较低反应性的官能团。官能团例如可以包括脂质底物中的不同C = C基团，主要是脂肪酸和脂肪酸衍生物，例如甘油三酯和甲基脂肪酸。可以通过此方法获得部分氢化的脂肪酸/脂肪酸衍生物，其具有低反式脂肪酸含量以及高选择性，如SLf值和Sao值。
• [EN] GLUCAGON ANTAGONISTS/INVERSE AGONISTS<br/>[FR] ANTAGONISTES/AGONISTES INVERSES DU GLUCAGON
  申请人：NOVO NORDISK AS

  公开号：WO2002000612A1

  公开（公告）日：2002-01-03

  A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.

  一种新型化合物，其作用是对抗胰高血糖素激素对胰高血糖素受体的作用。由于这些化合物对胰高血糖素受体的拮抗作用，因此这些化合物可能适用于治疗和/或预防任何需要胰高血糖素拮抗作用的疾病和障碍，例如高血糖症、1型糖尿病、2型糖尿病、脂质代谢障碍和肥胖症。