(9Z,9a(2)Z)-N,Na(2)-1,3-Propanediylbis[9-octadecenamide] | 5518-21-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (9Z,9a(2)Z)-N,Na(2)-1,3-Propanediylbis[9-octadecenamide]
• 英文别名: (Z)-N-[3-[[(Z)-octadec-9-enoyl]amino]propyl]octadec-9-enamide
• CAS: 5518-21-8
• 化学式: C₃₉H₇₄N₂O₂
• 分子量: 603.0
• InChiKey: ZSJXKBFCSWUGLX-CLFAGFIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.2
• 重原子数：
  43
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Multimeric Oleamide Derivative Having Connexin-26 Inhibiting Potency and Use Thereof in Cancer Therapy, etc.
  申请人：Nojima Hiroshi

  公开号：US20080089924A1

  公开（公告）日：2008-04-17

  The present invention relates to multimeric oleamide derivatives having connexin 26 inhibitory activities and embraces the dimer oleamide derivatives represented by the following formula (1) or a pharmacologically acceptable salt thereof: where n denotes an integer of 3, 5, or 8. The novel oleamide derivatives of the present invention can be used not only as research reagents, but also in a wide industrial field because they exhibit useful bioactivities such as cancer metastasis/growth inhibition. Thus they have various applications, such as in medicines, supplements, and functional foods, in addition to cancer-preventive and cancer-therapeutic drugs.

  本发明涉及具有connexin 26抑制活性的多聚性油酰胺衍生物，并包括由以下式（1）表示的二聚体油酰胺衍生物或其药理学可接受的盐：其中n表示3、5或8的整数。本发明的新型油酰胺衍生物不仅可以用作研究试剂，还可以在广泛的工业领域中使用，因为它们表现出有用的生物活性，如癌症转移/生长抑制。因此，它们具有各种应用，如在药物、补充剂和功能性食品中，除了癌症预防和癌症治疗药物。
• US7846972B2
  申请人：——

  公开号：US7846972B2

  公开（公告）日：2010-12-07
• [EN] FATTY ACID ANALOGS AND METHODS OF USE THEREOF<br/>[FR] ANALOGUES D'ACIDE GRAS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2016168469A1

  公开（公告）日：2016-10-20

  The present disclosure provides lipidoid compounds, and compositions comprising the lipidoid compounds and a nucleic acid. The present disclosure provides methods of making a subject lipidoid. The present disclosure provides a method of delivering a target nucleic acid to a cell, using a lipidoid composition of the present disclosure. The present disclosure provides a method of delivering a gene product to an individual, using a lipidoid composition of the present disclosure.