p-(p-acetamidobenzamido)phenol | 57790-88-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-(p-acetamidobenzamido)phenol
• 英文别名: p-(p-Acetamidobenzamido)-phenol；p-(p-Acetamidobenzamido) phenol；p-<(p-Acetamido-phenyl)-carbamoyl>-phenol；p-(p-Acetamido-benzamido)-phenol；4,4'-Acetamido-benzamidophenol；4-(acetylamino)-N-(4-hydroxyphenyl)benzamide；4-acetamido-N-(4-hydroxyphenyl)benzamide
• CAS: 57790-88-2
• 化学式: C₁₅H₁₄N₂O₃
• 分子量: 270.288
• InChiKey: USGOUVPJEDUBND-UHFFFAOYSA-N

物化性质

• 沸点：
  462.5±30.0 °C(Predicted)
• 密度：
  1.352±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对氨基苯酚 、 对乙酰氨基苯甲酸 、 氯甲酸异丁酯 在 三乙胺 作用下， 以 四氢呋喃 、 吡啶 为溶剂， 生成 p-(p-acetamidobenzamido)phenol
  参考文献：
  名称：

  Substituted tolyl esters of PGA.sub.1

  摘要：

  本文披露了PGA.sub.1的甲苯酯、15-烷基-PGA.sub.1、15(R)-15-烷基-PGA.sub.1及它们的外消旋形式，以及生产它们的方法。这些产品可用于与PGA.sub.1、15-烷基-PGA.sub.1和15(R)-15-烷基-PGA.sub.1相同的药理学和医学用途，并且还可用作获取高度纯化的PGA.sub.1、15-烷基-PGA.sub.1和15(R)-15-烷基-PGA.sub.1产品的手段。

  公开号：

  US03948970A1

文献信息

• 15-Epi-15-methyl-16-phenoxy-PGE compounds
  申请人：The Upjohn Company

  公开号：US04154950A1

  公开（公告）日：1979-05-15

  Prostaglandin E-, F.sub..alpha. -, F.sub..beta. -, A-, and B-type compounds are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they are substituted at C-16 with a phenoxy or substituted phenoxy, and have a lower alkyl group in place of the hydrogen at C-15 and/or a lower alkoxy group in place of the hydroxy group at C-15. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.

  本发明揭示了具有中间体和制备它们的过程的PGE-, F.sub..alpha. -, F.sub..beta. -, A-和B型化合物。这些化合物与前列腺素的不同之处在于它们在C-16处取代了苯氧基或取代苯氧基，并且在C-15处的氢原子被较低的烷基取代和/或在C-15处的羟基被较低的烷氧基取代。这些化合物可用于各种药理学用途，包括抗溃疡、抑制血小板聚集、增加鼻腔通畅、促进足月分娩和伤口愈合。
• Substituted tolyl esters of PGE.sub.1
  申请人：The Upjohn Company

  公开号：US03931285A1

  公开（公告）日：1976-01-06

  Substituted phenyl and naphthyl esters of PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1, and are also useful as a means for obtaining highly purified PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-alkyl-PGE.sub.1 products.

  揭示了PGE.sub.1的取代苯基和萘基酯，15-烷基-PGE.sub.1和15(R)-15-烷基-PGE.sub.1，以及它们的外消旋形式的产品，以及生产它们的方法。这些产品可用于与PGE.sub.1、15-烷基-PGE.sub.1和15(R)-15-烷基-PGE.sub.1相同的药理学和医学目的，并且还可用作获取高度纯化的PGE.sub.1、15-烷基-PGE.sub.1和15(R)-烷基-PGE.sub.1产品的手段。
• 2A,2B-Dihomo-15-alkyl-PGF.sub.2.sub..alpha. analogs
  申请人：The Upjohn Company

  公开号：US03974195A1

  公开（公告）日：1976-08-10

  2a,2b-Dihomo-15-methyl and 15-ethyl PGF- and PGE-type compounds are disclosed with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.

  本文介绍了制备2a,2b-二脱氢-15-甲基和15-乙基PGF-和PGE-型化合物的过程。这些化合物可用于各种药理学用途，包括抗溃疡、抑制血小板聚集、增加鼻通气、促进足月分娩和伤口愈合。
• Substituted anilide esters of 16-phenoxy and 17-phenyl PGE.sub.2 type
  申请人：The Upjohn Company

  公开号：US03994956A1

  公开（公告）日：1976-11-30

  Substituted phenyl and naphthyl esters of PGE.sub.2 analogs, including the 16-alkyl, 16-fluoro, 16-phenoxy, and phenyl-substituted analogs, and their 15-epimers, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as these PGE.sub.2 analogs, and are also useful as a means for obtaining highly purified 16,16-dimethyl-PGE.sub.2, 16-phenoxy-17,18,19,20-tetranor-PGE.sub.2, and 17-phenyl-18,19,20-trinor-PGE.sub.2.

  揭示了PGE.sub.2类似物的苯基和萘基酯，包括16-烷基，16-氟，16-苯氧基和苯基取代物，以及它们的15-顺式异构体，以及它们的外消旋形式，以及生产它们的过程。这些产品可用于与这些PGE.sub.2类似物相同的药理学和医学目的，并且还可用作获得高度纯化的16,16-二甲基-PGE.sub.2，16-苯氧基-17,18,19,20-四醇-PGE.sub.2和17-苯基-18,19,20-三醇-PGE.sub.2的手段。
• Substituted anilide ester of PGA.sub.2
  申请人：The Upjohn Company

  公开号：US03931281A1

  公开（公告）日：1976-01-06

  Substituted anilide esters of PGA.sub.2, 15-alkyl-PGA.sub.2, and 15(R)-15-alkyl-PGA.sub.2, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as PGA.sub.2, 15-alkyl-PGA.sub.2, and 15(R)-15-alkyl-PGA.sub.2, and are also useful as a means for obtaining highly purified PGA.sub.2, 15-alkyl-PGA.sub.2, and 15(R)-15-alkyl-PGA.sub.2 products.

  本发明揭示了PGA.sub.2，15-烷基-PGA.sub.2和15(R)-15-烷基-PGA.sub.2的取代苯胺酰酯及其外消旋形式的生产工艺。这些产品可用于与PGA.sub.2，15-烷基-PGA.sub.2和15(R)-15-烷基-PGA.sub.2相同的药理和医学目的，并且还可用作获得高度纯化的PGA.sub.2，15-烷基-PGA.sub.2和15(R)-15-烷基-PGA.sub.2产品的手段。