di-n-propyl tartrate | 150949-27-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: di-n-propyl tartrate
• 英文别名: D_g-tartaric acid dipropyl ester；(2S,3S)-2,3-dihydroxy-succinic acid dipropyl ester；di-n-propyl d-tartrate；dipropyl (2S,3S)-2,3-dihydroxybutanedioate
• CAS: 150949-27-2
• 化学式: C₁₀H₁₈O₆
• 分子量: 234.249
• InChiKey: WCHBXSPACACNBJ-YUMQZZPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  di-n-propyl tartrate 在 过碘酸 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 n-propyl glyoxylate
  参考文献：
  名称：

  Superoxide dismutase mimetics. Part 2: synthesis and structure–Activity relationship of glyoxylate- and glyoxamide-Derived metalloporphyrins

  摘要：

  Novel glyoxylate- and glyoxamide-derived metalloporphyrins 26-58 were synthesized and evaluated as potential superoxide dismutase (SOD) mimetics. Relative to previously studied MnTBAP analogues, the glyoxylate-derived metalloporphyrins 32, 39, and 54 and glyoxamide-derived metalloporphyrin 49, exhibited enhanced activity in the SOD assay and the majority of the analogues in the current series showed enhanced inhibition of lipid peroxidation and catalase activity. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00272-4
• 作为产物：
  描述：

  丙醇 、 L-酒石酸 在 硫酸 作用下， 以65%的产率得到di-n-propyl tartrate
  参考文献：
  名称：

  Substituted porphyrins

  摘要：

  本发明一般涉及调节生理和病理过程的方法，特别涉及调节氧化剂的细胞水平以及这些氧化剂参与的过程的方法。该发明还涉及适用于这些方法的化合物和组合物。本发明的化合物包括式I的化合物。

  公开号：

  US06479477B1

文献信息

• Some properties of 4,5-carboalkoxy-(2-diethylamino)-1,3,2-dioxaphospholanes
  作者：N. P. Grechkin、L. N. Grishina

  DOI：10.1007/bf00909581

  日期：1967.9
• SUBSTITUTED PORPHYRINS
  申请人：Duke University

  公开号：EP1071474B1

  公开（公告）日：2005-11-30
• US6479477B1
  申请人：——

  公开号：US6479477B1

  公开（公告）日：2002-11-12
• Substituted porphyrins
  申请人：Duke University

  公开号：US06479477B1

  公开（公告）日：2002-11-12

  The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods. Compounds of the invention include those of Formula I.

  本发明一般涉及调节生理和病理过程的方法，特别涉及调节氧化剂的细胞水平以及这些氧化剂参与的过程的方法。该发明还涉及适用于这些方法的化合物和组合物。本发明的化合物包括式I的化合物。
• Superoxide dismutase mimetics. Part 2: synthesis and structure–Activity relationship of glyoxylate- and glyoxamide-Derived metalloporphyrins
  作者：Michael P Trova、Polivina Jolicia F Gauuan、Anthony D Pechulis、Stephen M Bubb、Stephen B Bocckino、James D Crapo、Brian J Day

  DOI：10.1016/s0968-0896(03)00272-4

  日期：2003.7

  Novel glyoxylate- and glyoxamide-derived metalloporphyrins 26-58 were synthesized and evaluated as potential superoxide dismutase (SOD) mimetics. Relative to previously studied MnTBAP analogues, the glyoxylate-derived metalloporphyrins 32, 39, and 54 and glyoxamide-derived metalloporphyrin 49, exhibited enhanced activity in the SOD assay and the majority of the analogues in the current series showed enhanced inhibition of lipid peroxidation and catalase activity. (C) 2003 Elsevier Science Ltd. All rights reserved.