(R)-3-(tetradecanoyloxy)tetradecanoyl chloride | 106001-81-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-3-(tetradecanoyloxy)tetradecanoyl chloride
• 英文别名: (r)-3-Tetradecanoyloxytetradecanoic acid chloride；[(3R)-1-chloro-1-oxotetradecan-3-yl] tetradecanoate
• CAS: 106001-81-4
• 化学式: C₂₈H₅₃ClO₃
• 分子量: 473.18
• InChiKey: FQXFXMPTWFTCSG-AREMUKBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.5
• 重原子数：
  32
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-3-(tetradecanoyloxy)tetradecanoyl chloride 、 allyl 2-<(RS)-<3-<(benzyloxycarbonyl)oxy>-2,2-difluorotetradecanoyl>amino>-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranoside 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以79%的产率得到allyl 2-<(RS)-<3-<(benzyloxycarbonyl)oxy>-2,2-difluorotetradecanoyl>amino>-2-deoxy-4,6-O-isopropylidene-3-O-<(R)-3-(tetradecanoyloxy)tetradecanoyl>-β-D-glucopyranoside
  参考文献：
  名称：

  2-脱氧-2-[（（2，2-二氟-3-羟基十四烷酰基）氨基] -3-O-[（R）-3-（十四烷酰氧基）十四烷酰基] -D-吡喃葡萄糖4-磷酸的合成。

  摘要：

  将2-脱氧-2-[（（2,2-二氟-3-羟基十四烷酰基）氨基] -3-O-[（R）-3-（十四烷酰氧基）十四烷酰基] -D-吡喃葡萄糖4-磷酸盐（9H，L）由烯丙基2-氨基-2-脱氧-4,6-O-异亚丙基-β-D-吡喃葡萄糖苷（1），（+/-）-3-[（苄氧羰基）氧基] -2,2-二氟十四烷酸合成，和（R）-3-（十四烷酰氧基）十四烷酸。化合物9H和9L对巨噬细胞上的前列腺素D2释放测试均比GLA-60更具活性。

  DOI：

  10.1021/jm00112a045

文献信息

• Novel acyl-dipeptide-like compounds bearing an accessory functional side chain spacer, a method for preparing the same and pharmaceutical compositions containing such products
  申请人：Bauer Jacques

  公开号：US20050192232A1

  公开（公告）日：2005-09-01

  The present invention is directed in particular to dipeptide-like compounds derived from functionally substituted amino acids, having fatty acid chains bound thereto through amidification of the amine functional groups of said dipeptide-like compounds, one end portion of which bears an accessory functional side chain spacer, with the other end portion being an acid group either in neutral or charged state. Compounds of the present invention have immunomodulating properties like adjuvants, In addition, compounds of the invention can be grafted on a given antigen in order to modulate or tune the immune response or can be equally grafted on a pharmaceutical carrier to enhance the therapeutic effect or targetting thereof. Accordingly, compounds of the invention find use in human and veterinary medicine both as immunogens and diagnostic tools.

  该发明特别涉及类二肽样化合物，这些化合物源自功能性取代的氨基酸，通过酰胺化作用将脂肪酸链结合到所述类二肽样化合物的氨基官能团上，其中一端部分带有辅助功能侧链间隔物，另一端部分是酸基，可以是中性或带电状态。该发明的化合物具有类似佐剂的免疫调节特性。此外，该发明的化合物可以嫁接到给定抗原上，以调节或调整免疫反应，也可以嫁接到药物载体上，以增强治疗效果或靶向效果。因此，该发明的化合物在人类和兽医医学中均可用作免疫原和诊断工具。
• Acyl pseudodipeptides which carry a functionalised auxialiary arm
  申请人：——

  公开号：US20030203852A1

  公开（公告）日：2003-10-30

  The present invention is directed in particular to dipeptide-like compounds derived from functionally substituted amino acids, having fatty acid chains bound thereto through amidification of the amine functional groups of said dipeptide-like compounds, one end portion of which bears an accessory functional side chain spacer, with the other end portion being an acid group either in neutral or charged state. Compounds of the present invention have immunomodulating properties like adjuvants, In addition, compounds of the invention can be grafted on a given antigen in order to modulate or tune the immune response or can be equally grafted on a pharmaceutical carrier to enhance the therapeutic effect or targetting thereof. Accordingly, compounds of the invention find use in human and veterinary medicine both as immunogens and diagnostic tools.

  本发明特别涉及从功能性取代氨基酸衍生的二肽样化合物，其通过酰胺化作用将脂肪酸链结合到所述二肽样化合物的氨基功能团上，其中一端部分带有附属功能侧链间隔物，另一端部分是酸基，可以是中性或带电状态。本发明的化合物具有类似佐剂的免疫调节性质。此外，本发明的化合物可以嫁接到给定抗原上，以调节或调整免疫应答，或者可以嫁接到药物载体上，以增强治疗效果或靶向作用。因此，本发明的化合物在人类和兽医医学中均可用作免疫原和诊断工具。
• ACYL PSEUDOPEPTIDES WHICH CARRY A FUNCTIONALIZED AUXILIARY ARM
  申请人：BAUER Jacques

  公开号：US20130022628A1

  公开（公告）日：2013-01-24

  The present invention is directed in particular to dipeptide-like compounds derived from functionally substituted amino acids, having fatty acid chains bound thereto through amidification of the amine functional groups of said dipeptide-like compounds, one end portion of which bears an accessory functional side chain spacer, with the other end portion being an acid group either in neutral or charged state. Compounds of the present invention have immunomodulating properties like adjuvants. In addition, compounds of the invention can be grafted on a given antigen in order to modulate or tune the immune response or can be equally grafted on a pharmaceutical carrier to enhance the therapeutic effect or targeting thereof. Accordingly, compounds of the invention find use in human and veterinary medicine both as immunogens and diagnostic tools.

  本发明特别针对从功能取代的氨基酸中衍生出来的二肽类化合物，其通过酰胺化作用将脂肪酸链结合到所述二肽类化合物的胺基官能团上，其中一端部分具有辅助功能侧链间隔物，而另一端部分是一个酸基，可以是中性或带电状态。本发明的化合物具有类似佐剂的免疫调节特性。此外，本发明的化合物可以嫁接到给定的抗原上，以调节或调整免疫反应，也可以同样嫁接到药物载体上，以增强其治疗效果或靶向性。因此，本发明的化合物在人类和兽医医学中均可用作免疫原和诊断工具。
• ACYL PSEUDODIPEPTIDES WHICH CARRY A FUNCTIONALIZED AUXILIARY ARM
  申请人：BAUER Jacques

  公开号：US20100215685A1

  公开（公告）日：2010-08-26

  The present invention is directed in particular to dipeptide-like compounds derived from functionally substituted amino acids, having fatty acid chains bound thereto through amidification of the amine functional groups of said dipeptide-like compounds, one end portion of which bears an accessory functional side chain spacer, with the other end portion being an acid group either in neutral or charged state. Compounds of the present invention have immunomodulating properties like adjuvants, In addition, compounds of the invention can be grafted on a given antigen in order to modulate or tune the immune response or can be equally grafted on a pharmaceutical carrier to enhance the therapeutic effect or targeting thereof. Accordingly, compounds of the invention find use in human and veterinary medicine both as immunogens and diagnostic tools.

  本发明特别针对从功能取代氨基酸衍生的二肽类化合物，其通过酰胺化反应将脂肪酸链结合到所述二肽类化合物的胺基官能团上，其中一端部分具有辅助功能侧链间隔物，而另一端部分是中性或带电酸基。本发明的化合物具有免疫调节特性，如辅助剂。此外，本发明的化合物可以嫁接到给定的抗原上，以调节或调整免疫反应，也可以同样嫁接到药物载体上，以增强其治疗效果或靶向作用。因此，本发明的化合物在人类和兽医学中均可用作免疫原和诊断工具。
• US7799762B2
  申请人：——

  公开号：US7799762B2

  公开（公告）日：2010-09-21