N-cyclohexyl-stearoyl amide | 10251-00-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-cyclohexyl-stearoyl amide
• 英文别名: N-Cyclohexyl-stearinsaeureamid；Octadecanamide, N-cyclohexyl-；N-cyclohexyloctadecanamide
• CAS: 10251-00-0
• 化学式: C₂₄H₄₇NO
• 分子量: 365.643
• InChiKey: WJWAWHQJIVUVGL-UHFFFAOYSA-N

物化性质

• 熔点：
  100 °C
• 沸点：
  505.2±17.0 °C(Predicted)
• 密度：
  0.89±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.8
• 重原子数：
  26
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  环己胺 、 硬脂酸 以0.87%的产率得到N-cyclohexyl-stearoyl amide
  参考文献：
  名称：

  USE OF ENDOCANNABINOID-LIKE COMPOUNDS FOR TREATING CNS DEGENERATIVE DISORDERS

  摘要：

  公开号：

  EP1592418B1

文献信息

• Thermosensitive recording material
  申请人：Ricoh Company, Ltd.

  公开号：US04352860A1

  公开（公告）日：1982-10-05

  A thermosensitive recording material comprising a support member and a thermosensitive layer formed on the support member, which thermosensitive layer contains a colorless or light-colored leuco dye and acidic material, capable of forming a color upon application of heat to the thermosensitive layer, and at least one amide compound selected from the group consisting of amide compounds represented by the formulas ##STR1## wherein R.sub.1 represents an alkyl group with 1 to 30 carbon atoms, a phenyl group or a substituted phenyl group; R.sub.2 represents hydrogen or an alkyl group with 1 to 4 carbon atoms; R.sub.3 represents an alkyl group with 1 to 30 carbon atoms; R.sub.4 and R.sub.5 individually represent hydrogen, a halogen atom, an alkyl group with 1 to 4 carbon atoms or an alkoxy group with 1 to 4 carbon atoms; and n is an integer, 0 or 1, whereby image formation is improved with respect to the image density, the quantity of energy required for image formation, and thermal head operation on the thermosensitive recording material, and a compound represented by the formula ##STR2## wherein R.sub.6 and R.sub.7 individually represent an alkyl group with 10 to 30 carbon atoms, whereby prevention of discoloration of the recording material by pressure or friction is achieved.

  一种热敏记录材料，包括支撑成员和形成在支撑成员上的热敏层，所述热敏层包含一种无色或浅色的亚胺染料和酸性物质，能够在施加热能到热敏层时形成颜色，并且至少包括从以下群组中选择的一种亚胺化合物：##STR1## 其中R.sub.1代表1到30个碳原子的烷基，苯基或取代苯基；R.sub.2代表氢或1到4个碳原子的烷基；R.sub.3代表1到30个碳原子的烷基；R.sub.4和R.sub.5分别代表氢、卤素原子、1到4个碳原子的烷基或1到4个碳原子的烷氧基；n是整数0或1，从而提高了热敏记录材料的图像形成方面的图像密度、图像形成所需能量的数量和热头操作，并且包括一种化合物，其表示式为：##STR2## 其中R.sub.6和R.sub.7分别代表10到30个碳原子的烷基，从而实现了通过压力或摩擦防止记录材料褪色。
• ACYLATION REACTION OF HYDROXYL GROUP
  申请人：Mashima Kazushi

  公开号：US20100249422A1

  公开（公告）日：2010-09-30

  Disclosed is a selective ester production process of an alcoholic hydroxyl group, which proceeds under chemically mild conditions, while having adequate environmental suitability, operability and economical efficiency. Specifically disclosed is a process for producing an ester compound, which is characterized in that an alcohol and a carboxylic acid ester compound are reacted in the presence of a compound containing zinc element, thereby selectively acylating a hydroxyl group of the alcohol.

  公开了一种选择性酯化醇羟基的生产过程，该过程在化学上温和的条件下进行，同时具有足够的环境适应性、操作性和经济效益。具体公开了一种生产酯化合物的方法，其特征在于，在含锌元素的化合物存在下，将醇和羧酸酯化合物反应，从而选择性地酰化醇的羟基。
• New endocannabinoid-like compounds and their use
  申请人：RESEARCH & INNOVATION SOC. COOP. A R.L.

  公开号：EP1900365A2

  公开（公告）日：2008-03-19

  The present invention describes compounds deriving from chemical reactions between saturated or monounsaturated acyl derivatives and primary amines or primary alcohols that display specific cannabinoid-like pharmacological activity without exhibiting the central unwanted side effects typical of synthetic cannabinoids or endocannabinoids acting on central cannabinoid (CB1) receptors. These compounds, having this pharmacological activity, may be utilised to prevent or to treat pathological conditions and diseases in mammals, including human subjects, that may undergo a clinical improvement upon their administration.

  本发明描述了由饱和或单不饱和酰基衍生物与伯胺或伯醇之间的化学反应所产生 的化合物，这些化合物显示出类似大麻素的特殊药理活性，而不会表现出合成大麻 素或作用于中枢大麻素（CB1）受体的内源性大麻素所特有的中枢性不良副作用。这些具有这种药理活性的化合物可用于预防或治疗哺乳动物（包括人类）的病理状况和疾病，服用后可改善临床症状。
• Radical mediated-direct conversion of aldehydes into acid bromides
  作者：Dong Ho Kang、Tae Young Joo、Warinthorn Chavasiri、Doo Ok Jang

  DOI：10.1016/j.tetlet.2006.11.013

  日期：2007.1

  A method of preparing acid bromides directly from aldehydes with Br3CCO2Et under radical conditions was developed. Aromatic aldehydes with electron-donating group were found to be more reactive than aromatic aldehydes with electron-withdrawing group and aliphatic aldehydes under reaction conditions. (c) 2006 Elsevier Ltd. All rights reserved.
• AVRAMOVICI-GRISARU, S.;SAREL, S., NOUV. J. CHIM., 1982, 6, N 10, 455-457
  作者：AVRAMOVICI-GRISARU, S.、SAREL, S.

  DOI：——

  日期：——