(1R)-1-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonane | 1371667-59-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (1R)-1-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonane
• 英文别名: (1R,2S,4R,5S)-1-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonane
• CAS: 1371667-59-2
• 化学式: C₂₁H₂₅N
• 分子量: 291.436
• InChiKey: DENJKFOHTUMCNP-UWHLTILDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1R)-1-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonane 在 盐酸 、 双氧水 、 三氟乙酸酐 、 sodium nitrite 作用下， 以 二氯甲烷 、 氯仿 、 水 为溶剂， 反应 1.0h， 生成 (1R)-N-nitro-1-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonane
  参考文献：
  名称：

  Spontaneous generation of chirality and chiroptical spectra of N-nitroso-2,4-diaryl-3-azabicyclo[3.3.1]nonanes

  摘要：

  The crystal structures of several bicyclic N-nitrosamines indicate that they crystallize in the chiral (Sohncke) space group P2(1)2(1)2(1) as conglomerates. This allows the resolution of these compounds by manual picking of the enantiomorphous crystals. The optical activity of the single crystals was confirmed by their CD spectra taken in KBr disks. The absolute configurations of the title nitrosamines were assigned by crystallographic measurements and by a comparison of their CD spectra with those of a reference compound resolved by classical methods. The observed Cotton effect signs, corresponding to the n-pi* transition, were correlated with the helicity of the inherently chiral nitrosamine chromophore. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.02.012
• 作为产物：
  描述：

  2-甲基环己酮 在 ammonium acetate 作用下， 以 甲苯 为溶剂， 生成 (1R)-1-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonane
  参考文献：
  名称：

  Spontaneous generation of chirality and chiroptical spectra of N-nitroso-2,4-diaryl-3-azabicyclo[3.3.1]nonanes

  摘要：

  The crystal structures of several bicyclic N-nitrosamines indicate that they crystallize in the chiral (Sohncke) space group P2(1)2(1)2(1) as conglomerates. This allows the resolution of these compounds by manual picking of the enantiomorphous crystals. The optical activity of the single crystals was confirmed by their CD spectra taken in KBr disks. The absolute configurations of the title nitrosamines were assigned by crystallographic measurements and by a comparison of their CD spectra with those of a reference compound resolved by classical methods. The observed Cotton effect signs, corresponding to the n-pi* transition, were correlated with the helicity of the inherently chiral nitrosamine chromophore. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.02.012