N-ethyltetradecanamide | 91084-04-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-ethyltetradecanamide
• 英文别名: N-Ethylmyristamide；Myristamide, N-ethyl-
• CAS: 91084-04-7
• 化学式: C₁₆H₃₃NO
• 分子量: 255.444
• InChiKey: HODFTZHFCOHHMM-UHFFFAOYSA-N

物化性质

• 沸点：
  327.5±10.0 °C(Predicted)
• 密度：
  0.855±0.06 g/cm3(Predicted)
• 保留指数：
  2078

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-ethyltetradecanamide 在 甲醇 、 ammonium hydroxide 、 sodium acetate 、 二氧化氮 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 正十四烷基铵
  参考文献：
  名称：

  Reaction of N-nitroso- and N-nitro-N-alkylamides with amines

  摘要：

  DOI：

  10.1021/jo00192a014
• 作为产物：
  描述：

  乙胺 、 肉豆蔻酸 在 acrylic resin-bound Candida antarctica lipase B 作用下， 以 poly(ethylene glycol) 600 为溶剂， 反应 4.0h， 生成 N-ethyltetradecanamide
  参考文献：
  名称：

  Lipase-catalyzed transformations using poly(ethylene glycol) as solvent

  摘要：

  Candida antarctica lipase catalyzes a number of elementary reactions like alcoholysis, ammoniolysis and aminolysis in poly(ethylene glycol) (PEG) media. Reaction rates were comparable to or better than those observed in conventional organic reaction media and ionic liquids. It is envisaged that PEGs could have added benefits for performing biotransformations with highly polar substrates, which are sparingly soluble in common organic solvents.

  DOI：

  10.3109/10242422.2011.578739

文献信息

• Studies on Crude Drugs Effective on Visceral Larva Migrans. Part XVI. Nematocidal Activity of Long Alkyl Chain Amides, Amines, and Their Derivatives on Dog Roundworm Larvae.
  作者：Fumiyuki KIUCHI、Satomi NISHZAWA、Hiromi KAWANISHI、Sayuri KINOSHITA、Hisanao OHSIMA、Akiyo UCHITANI、Noriko SEKINO、Miki ISHIDA、Kaoru KONDO、Yoshisuke TSUDA

  DOI：10.1248/cpb.40.3234

  日期：——

  activity of amides and amines having a long alkyl chain against the second-stage larva of dog roundworm, Toxocara canis, was examined. Long chain acyl amides with smaller substituents on the nitrogen showed stronger activity and the activity of cyclic amine amides was stronger than that of acyclic ones. In a series of homologous amides, the activity was dependent on the alkyl chain length: it reached

  检查了具有长烷基链的酰胺和胺对犬round虫第二阶段幼虫的杀线虫活性。在氮上具有较小取代基的长链酰基酰胺显示出更强的活性，环状胺酰胺的活性强于无环酰胺。在一系列同源酰胺中，活性取决于烷基链长：在最佳链长处达到最大值，而在较短和较长的同系物中均降低。通过使用双线性模型分析了同系物的活性与疏水性之间的关系。对于所有中性酰胺，提供最大活性的化合物的疏水性均相似，但分子中具有额外胺基的酰胺具有不同的值。具有长烷基链的叔胺及其盐也具有与相应酰胺相当的杀线虫活性。这些盐以低于其临界胶束浓度的浓度杀死幼虫，表明它们表现为杀线虫作用的单个分子。
• NOVEL 1,3-BENZOXAZOL-2(3H)-ONES AND THEIR USE AS MEDICAMENTS AND COSMETICS
  申请人：DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL

  公开号：US20150111935A1

  公开（公告）日：2015-04-23

  The present invention relates to a novel class of 1,3-benzoxazol-2(3H)-ones and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema and/or pro-allergic or allergic conditions in a patient. Usually they are topically applied to the skin or mucosa in the form of a pharmaceutical or cosmetic composition comprising the compound and a pharmaceutically and/or cosmetically acceptable carrier.

  本发明涉及一种新型的1,3-苯并噁唑-2(3H)-酮类化合物及其作为药物的用途，尤其是作为皮肤科药剂和化妆品的用途。这些新型化合物在治疗和/或预防患者的炎症、刺激、瘙痒、瘙痒、疼痛、水肿和/或过敏症状方面特别有用。通常它们以药用或化妆品组合物的形式局部应用于皮肤或黏膜，包括该化合物和一种药学和/或化妆学可接受的载体。
• Peroxygen bleaching and compositions therefor
  申请人：FMC Corporation

  公开号：EP0001495A1

  公开（公告）日：1979-04-18

  A process of removing soil and/or stains from fabrics by immersing the fabrics in a peroxygen bleach bath containing as a peroxygen activator a phenyl sulfonate ester of the formula: wherein R is selected from the class consisting of a hydrocarbon radical of 1 to 16 carbon atoms and a heterocyclic radical having 1 ring or 2 fused rings, said ring or rings containing 5 to 6 members of which 1 to 2 are heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; X is hydrogen or at least one electron withdrawing substituent and n is an integer of from 1 to 5. Also described are dry blend compositions containing the bleach bath components.

  一种去除织物上的污垢和/或污渍的工艺，方法是将织物浸入过氧漂白浴中，过氧漂白浴中的过氧活化剂是式中的苯磺酸酯： 其中 R 选自 1 至 16 个碳原子的烃基和具有 1 个环或 2 个融合环的杂环基，所述环或环含有 5 至 6 个成员，其中 1 至 2 个为杂原子，选自氮、氧和硫组成的组；X 为氢或至少一个取电子取代基，n 为 1 至 5 的整数。还描述了含有漂白浴成分的干混组合物。
• Peroxygen containing compositions and bleaching process
  申请人：FMC Corporation

  公开号：EP0009998A1

  公开（公告）日：1980-04-16

  Soil and/or stains are/is removed from fabrics by immersing the fabrics in a peroxygen bleach bath containing as a peroxygen activator an N-sulfonyl-azole of the formula: where Z represents the number of carbon and nitrogen atoms necessary to complete a pyrazole, pyrrole, triazole, or benzotriazole ring, in which the ring can be substituted with phenyl, C1-10 alkyl, halogen, amino, cyano, nitro or C1-10 alkoxy and R is a C1-10 alkyl radical. Peroxygen-containing compositions contain a peroxygen compound and an N-sulfonylazole compound as defined above and may also optionally contain one or more of a detergent, water, a buffering agent and a detergency builder.

  将织物浸泡在含有过氧活化剂 N-磺酰基唑的过氧漂白浴中，可去除织物上的污垢和/或污渍： 式中 Z 代表完成吡唑、吡咯、三唑或苯并三唑环所需的碳原子和氮原子数，其中环可被苯基、C1-10 烷基、卤素、氨基、氰基、硝基或 C1-10 烷氧基取代，R 为 C1-10 烷基。 含过氧化合物包含过氧化合物和如上定义的 N-磺酰基唑化合物，还可选择包含一种或多种洗涤剂、水、缓冲剂和去污剂。
• Bleach composition and process for preparing it
  申请人：FMC Corporation

  公开号：EP0042941A1

  公开（公告）日：1982-01-06

  Bleaching compositions containing a chlorine bleaching agent coated with a silicate bound, hydrated, soluble salt containing an N-H chlorine accepting compound are described. Such compositions exhibit decreased localized dye attack of colored fabrics.

  描述了含有氯漂白剂的漂白组合物，该氯漂白剂涂有硅酸盐结合的、水合的、含有 N-H 氯接受化合物的可溶性盐。这种组合物能减少有色织物的局部染料侵蚀。