3,3-dimorpholino-1H-indol-2(3H)-one | 2947-23-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,3-dimorpholino-1H-indol-2(3H)-one
• 英文别名: 3,3'-bis(morpholino)oxindole；3,3-bis(morpholino)oxindole；3,3-di-morpholin-4-yl-1,3-dihydro-indol-2-one；3,3-Dimorpholino-indolin-2-on；3,3-Dimorpholino-oxindol；3,3-dimorpholin-4-yl-1H-indol-2-one
• CAS: 2947-23-1
• 化学式: C₁₆H₂₁N₃O₃
• 分子量: 303.361
• InChiKey: ITTSUPBAEPLODX-UHFFFAOYSA-N

物化性质

• 熔点：
  120 °C (decomp)
• 沸点：
  479.1±45.0 °C(Predicted)
• 密度：
  1.296±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  54
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,3-dimorpholino-1H-indol-2(3H)-one 在 水 、 溶剂黄146 作用下， 生成 靛红
  参考文献：
  名称：

  吲哚系列α-氧代亚砜的合成

  摘要：

  发现羟吲哚易于与亚硫酰氯反应，以优异的产率得到可分离的亚砜（13a），将其加热（回流乙腈）得到异靛蓝（15a）。暗紫色的3-磺胺基-吲哚（13a）易于与2,3-二甲基丁二烯反应，得到无色的环加合物（14a）。硫磺也容易与各种亲核试剂反应，因此，硫代乙酸可生成3-羧甲基硫代-羟吲哚（23a）。J.杂环化​​学。（2010）。

  DOI：

  10.1002/jhet.453
• 作为产物：
  描述：

  吗啉 、 3-phenylimino-2-indolinone 在 甲醇 、 xylene 作用下， 生成 3,3-dimorpholino-1H-indol-2(3H)-one
  参考文献：
  名称：

  691.靛蓝的结构

  摘要：

  DOI：

  10.1039/jr9570003470

文献信息

• X=Y-ZH compounds as potential 1,3-Dipoles. Part 281,2 the iminium ion route to azomethine ylides. background and reaction of amines with bifunctional ketones.
  作者：Harriet Ardill、M.J.R. Dorrity、Ronald Grigg、Mooi-Sin Leon-Ling、J.F. Malone、Visuvanathar Sridharan、Sunit Thianpatanagul.

  DOI：10.1016/s0040-4020(01)96013-2

  日期：1990.1

  The reaction of isatin, ninhydrin and acenaphthenequinone with primary and secondary amines gives rise to stereospecific formation of intermediate azomethine ylides which can be trapped by cycloaddition to methyl acrylate or N-methylmaleimide. The regiochemistry of the cycloadditions to methyl acrylate is controlled by both frontier orbital and steric interactions with the latter dominating in the

  靛红，茚三酮和啶醌与伯胺和仲胺的反应引起中间体偶氮甲亚胺基立体定向形成，该中间体可通过环加成而被捕集到丙烯酸甲酯或N-甲基马来酰亚胺中。丙烯酸甲酯的环加成物的区域化学反应受前沿轨道和空间相互作用的控制，在所研究的实例中，后者占主导地位。
• A method of forming an image, and an imaging element for inhibiting image formation with cobalt (III) complexes
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0003263A1

  公开（公告）日：1979-08-08

  An imaging element contains an energy-activatable image precursor composition comprising a cobalt III complex having releasable ligands which react with an image forming material to form a visible image. The element also contains a photoinhibitor which, on activating exposure, inhibits the release of ligands from the cobalt III complex or inhibits their image forming action. Images may be formed by imagewise activating the photoinhibitor, preferably with radiation longer than 300 nm, and thereafter activating the image precursor composition, for instance by heating. Images of a different sense may be formed by varying the exposure and activation treatments of the element.

  一种成像元件包含一种能量可激活的成像前体组合物，该组合物由钴 III 复合物组成，该钴 III 复合物具有可释放的配体，这些配体与成像材料反应形成可见图像。 该元件还包含一种光抑制剂，该光抑制剂在激活曝光时可抑制配体从钴 III 复合物中释放或抑制其成像作用。 可以通过成像激活光抑制剂（最好使用长于 300 纳米的辐射），然后激活成像前体组合物（例如通过加热）来形成图像。 可以通过改变元件的曝光和激活处理来形成不同意义的图像。
• Process for preparing alpha,alpha-disubstituted aromatics and heteroaromatics as cognition enhancers
  申请人：THE DU PONT MERCK PHARMACEUTICAL COMPANY

  公开号：EP0532054A1

  公开（公告）日：1993-03-17

  Cognitive defeciencies or neurological dysfunction in mammals are treated with α,α-disubstituted aromatic or heteroaromatic compounds. The compounds have the formula: or a salt thereof    wherein X and Y are taken together to form a saturated or unsaturated carbocyclic or heterocyclic first ring and the shown carbon in said ring is α to at least one additional aromatic ring or heteroaromatic ring fused to the first ring;    one of Het¹ or Het² is 2, 3, or 4-pyridyl or 2, 4, or 5-pyrimidinyl and the other is selected from (a) 2, 3, or 4-pyridyl, (b) 2, 4, or 5-pyrimidinyl, (c) 2-pyrazinyl, (d) 3, or 4-pyridazinyl, (e) 3, or 4-pyrazolyl, (f) 2, or 3-tetrahydrofuranyl, and (g) 3-thienyl.

  α，α-二取代芳香族或杂芳族化合物可治疗哺乳动物的认知缺陷或神经功能障碍。这些化合物的化学式如下 或其盐 其中 X 和 Y 共同形成饱和或不饱和碳环或杂环的第一环，所述环中所示碳与融 入第一环的至少一个附加芳环或杂芳环相连； Het¹ 或 Het² 中的一个是 2、3 或 4-吡啶基或 2、4 或 5-嘧啶基，另一个选自以下各项 (a) 2、3 或 4-吡啶基、 (b) 2、4 或 5-嘧啶基、 (c) 2-吡嗪基、 (d) 3 或 4-哒嗪基、 (e) 3 或 4-吡唑基、 (f) 2 或 3-四氢呋喃基，以及 (g) 3-噻吩基。
• Studies of the Reaction between Indole-2,3-diones (Isatins) and Secondary Aliphatic Amines.
  作者：Jan Bergman、Claes Stålhandske、Hans Vallberg

  DOI：10.3891/acta.chem.scand.51-0753

  日期：——

  Simple secondary aliphatic amines react with isatin to yield, depending on the structure, either 2-amino-phenylglyoxamides, such as 2-amino-N,N-dimethyl-phenylglyoxamide, or dialkylammonium salts of 2-aminophenylglyoxylic acids. Reaction of isatin with N,N'-dimethylethylenediamine gave an unusual 2:1 product, whose structure has been determined by X-ray crystallography.
• Reactions of 2′-oxo-1′,2′-dihydrospiro[cyclopropane-1,3′-indole]-2,2,3,3-tetracarbonitriles with nucleophiles
  作者：Ya. S. Kayukov、O. V. Kayukova、E. S. Kalyagina、I. N. Bardasov、O. V. Ershov、O. E. Nasakin、V. A. Tafeenko

  DOI：10.1134/s1070428011030110

  日期：2011.3

  2'-Oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2,2,3,3-tetracarbonitriles reacted with oxygen-centered nucleophiles to form addition products at the cyano groups with conservation of the three-membered ring. Reactions of the title compounds with alcohols required the presence of base catalyst, and the products, 2-amino-4,4-dialkoxy-2'-oxo-1',2'-dihydrospiro[3-azabicyclo[3.1.0]hex-2-ene-6,3'-indole]-1,5-dicarbonitriles, were converted into the corresponding 2-imino-2',4-dioxospiro[3-azabicyclo[3.1.0]hexane-6,3'-indole]-1,5-dicarbonitriles and 2,2',4-trioxospiro[3-azabicyclo[3.1.0] hexane-6,3'-indole]-1,5-dicarbonitriles by the action of acetic and sulfuric acids, respectively. The reactions with ketone oximes occurred in the absence of a catalyst, yielding 2-amino-4,4-bis(alkylideneaminooxy)-2'-oxo-1',2'-dihydrospiro[3-azabicyclo[3.1.0] hex-2-ene-6,3'-indole]-1,5-dicarbonitriles. The reactions with thiols, aliphatic amines, and anilines were accompanied by opening of the three-membered ring. In the reactions with triphenylphosphine and thiols 2-(2-oxo-2,3-dihydro-1H-indol-3-ylidene) malononitrile was obtained, while morpholine and N,N-dimethylaniline gave rise, respectively, to 3,3-diaryl- and 3,3-dimorpholino-1H-indol-2(3H)-ones and tri- and dicyanoethylene derivatives.