2'-methyl-3-(2-methyl-5-nitro-1H-indol-3-yl)-7'-nitro-3,3'-biindolin-2-one | 1370714-32-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2'-methyl-3-(2-methyl-5-nitro-1H-indol-3-yl)-7'-nitro-3,3'-biindolin-2-one
• 英文别名: 3,3-bis(2-methyl-5-nitro-1H-indol-3-yl)-1H-indol-2-one
• CAS: 1370714-32-1
• 化学式: C₂₆H₁₉N₅O₅
• 分子量: 481.467
• InChiKey: MIANTHWUEXMSLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  36
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  152
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-甲基-5-硝基吲哚 、 靛红 在 碘 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以78%的产率得到2'-methyl-3-(2-methyl-5-nitro-1H-indol-3-yl)-7'-nitro-3,3'-biindolin-2-one
  参考文献：
  名称：

  Iodine-catalyzed condensation of isatin with indoles: A facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity

  摘要：

  Isatin reacts smoothly with indoles in the presence of a catalytic amount of molecular iodine under mild conditions to afford a novel class of di(indolyl)indolin-2-one derivatives in good yields. These molecules are found to possess a promising cytotoxicity against cancer cells only but not on normal cells. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.011

文献信息

• Iodine-catalyzed condensation of isatin with indoles: A facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity
  作者：B.V. Subba Reddy、N. Rajeswari、M. Sarangapani、Y. Prashanthi、Roopa Jones Ganji、Anthony Addlagatta

  DOI：10.1016/j.bmcl.2012.02.011

  日期：2012.4

  Isatin reacts smoothly with indoles in the presence of a catalytic amount of molecular iodine under mild conditions to afford a novel class of di(indolyl)indolin-2-one derivatives in good yields. These molecules are found to possess a promising cytotoxicity against cancer cells only but not on normal cells. (C) 2012 Elsevier Ltd. All rights reserved.