3-(4-oxo-2-piperidin-1-yl-4H-thiazol-5-ylidene)-1,3-dihydro-indol-2-one | 326878-41-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(4-oxo-2-piperidin-1-yl-4H-thiazol-5-ylidene)-1,3-dihydro-indol-2-one
• 英文别名: RU100840；5-(2-oxo-1H-indol-3-ylidene)-2-piperidin-1-yl-1,3-thiazol-4-one
• CAS: 326878-41-5
• 化学式: C₁₆H₁₅N₃O₂S
• mdl: MFCD01815827
• 分子量: 313.38
• InChiKey: MBKHHQCWPKMAPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.47
• 重原子数：
  22.0
• 可旋转键数：
  0.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  61.77
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  哌啶 、 罗丹宁 、 靛红 在 heterogeneous silica supported pyridine catalyst 作用下， 以 乙醇 、 水 为溶剂， 以91%的产率得到3-(4-oxo-2-piperidin-1-yl-4H-thiazol-5-ylidene)-1,3-dihydro-indol-2-one
  参考文献：
  名称：

  Synthesis of molecular scaffolds assimilating both indolinone and thiazolidinone moieties under environmentally benevolent conditions

  摘要：

  A chromatography free synthesis of 2-amino-5-isatinylidenethiazol-4-ones from rhodanine, isatin, and amine under environmentally benevolent conditions is reported for the first time. The molecular scaffolds assimilating both indolinone and thiazolidinone moieties are reported to have great biological significance. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.052

文献信息

• γ-Aminobutyric acid hydrochloride supported on superparamagnetic γ-Fe2O3@SiO2 as a novel heterogeneous nanocatalyst for the synthesis of 2-amino-5-alkylidene-thiazol-4-one derivatives
  作者：Hadi Mohammadi、Hamid Reza Shaterian

  DOI：10.1007/s13738-018-1527-4

  日期：2019.3

  γ-Aminobutyric acid hydrochloride immobilized on superparamagnetic γ-Fe2O3@SiO2 nanoparticles as a novel heterogeneous nanocatalyst was prepared for the first times. It was characterized by several techniques such as XRD, FT-IR, VSM, FE-SEM, EDS, and TGA analysis. The heterogeneous nanocatalyst was used for a convenient, mild, and one-pot efficient three-component preparation of 2-amino-5-alkylidene-thiazol-4-one

  γ氨基丁酸盐酸盐固定在超顺磁性了γ-Fe 2 ö 3 @SiO 2个纳米颗粒作为一种新颖的多相纳米催化剂是用于第一时间制备。它的特征在于多种技术，例如XRD，FT-IR，VSM，FE-SEM，EDS和TGA分析。该多相纳米催化剂用于在室温下绿色条件下方便，温和且一锅高效地制备2-氨基-5-亚烷基-噻唑-4-酮衍生物的三组分。该方法的主要优点是易于通过外部磁体从反应混合物中回收稳定的纳米催化剂。
• Synthesis of molecular scaffolds assimilating both indolinone and thiazolidinone moieties under environmentally benevolent conditions
  作者：Suman Ray、Chhanda Mukhopadhyay

  DOI：10.1016/j.tetlet.2013.07.052

  日期：2013.9

  A chromatography free synthesis of 2-amino-5-isatinylidenethiazol-4-ones from rhodanine, isatin, and amine under environmentally benevolent conditions is reported for the first time. The molecular scaffolds assimilating both indolinone and thiazolidinone moieties are reported to have great biological significance. (C) 2013 Elsevier Ltd. All rights reserved.