Isobutyl ricinoleate | 3645-96-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Isobutyl ricinoleate
• 英文别名: 2-methylpropyl (Z,12R)-12-hydroxyoctadec-9-enoate
• CAS: 3645-96-3；71067-22-6
• 化学式: C₂₂H₄₂O₃
• 分子量: 354.6
• InChiKey: RLLIKXPTKNBNBZ-YXAHYSCSSA-N

物化性质

• 沸点：
  239-240 °C(Press: 10 Torr)
• 密度：
  0.916±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  25
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• METHOD OF TREATING INFECTIOUS DISEASE, METHOD OF PREVENTING PUTREFACTION OF COSMETIC, AND ANTIBACTERIAL/ANTIFUNGAL AGENT AND COSMETIC
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0589047A1

  公开（公告）日：1994-03-30

  A method of treating infectious diseases caused by bacteria or fungi by administering a zinc compound and at least one compound selected from the group consisting of hinokitiol and salts thereof; a method of preventing putrefaction of cosmetics by adding thereto a zinc compound and at least one compound selected from the group consisting of hinokitiol and salts thereof; and antibacterial/antifungal agents and cosmetics each containing a zinc compound and at least one compound selected from the goup consisting of hinokitiol and salts thereof.

  一种通过施用锌化合物和至少一种选自桧皮酚及其盐类的化合物来治疗由细菌或真菌引起的传染性疾病的方法；一种通过在化妆品中添加锌化合物和至少一种选自桧皮酚及其盐类的化合物来防止化妆品腐败的方法；以及含有锌化合物和至少一种选自桧皮酚及其盐类的化合物的抗菌/抗真菌剂和化妆品。
• ANTIMICROBIAL METHOD AND COSMETIC COMPOSITION
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0728478A1

  公开（公告）日：1996-08-28

  An object of the present invention is to provide an antimicrobial method using a composition which is excellent in antimicrobial activity and light stability, low in toxicity and very weak in side effects. The composition for use in the antimicrobial method of the present invention comprises a copper compound and at least one member selected from hinokitiol and salts thereof, or comprises at least one member selected from hinokitiol-copper or zinc complex and salts thereof.

  本发明的目的是提供一种使用组合物的抗菌方法，该组合物具有优异的抗菌活性和光稳定性、低毒性和极弱的副作用。 用于本发明抗菌方法的组合物包括铜化合物和至少一种选自桧醇及其盐类的成分，或包括至少一种选自桧醇-铜或锌复合物及其盐类的成分。
• REMEDY FOR ROSACEA
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0908181A1

  公开（公告）日：1999-04-14

  A rosacea treating agent is provided, which is effective even on intractable rosacea which cannot be cured completely by antibiotics such as minocycline, has low toxicity, causes little side effect, and is of long duration. The rosacea treating agent of the present invention comprises, as an active ingredient, at least one selected from the group consisting of benzoheterocyclic derivatives represented by the following formula (1): wherein R is a lower alkyl group; and X is a halogen atom, and salts thereof.

  本发明提供了一种酒糟鼻治疗剂，它对米诺环素等抗生素无法完全治愈的顽固性酒糟鼻也有效，毒性低，副作用小，持续时间长。本发明的红斑痤疮治疗剂作为活性成分，包括至少一种选自下式（1）所代表的苯并杂环衍生物： 其中 R 是低级烷基；X 是卤素原子，以及它们的盐。
• CHLOASMA AMELIORATION COMPOSITION AND DULLNESS AMELIORATION COMPOSITION
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1512405A1

  公开（公告）日：2005-03-09

  The present invention provides a composition that can effectively improve melasma and a composition that can effectively reduce skin dullness. The composition for improving melasma comprises a purine nucleic acid-related substance and a pharmaceutically or cosmetically acceptable carrier, and exhibits an excellent melasma improving effect due to the action of the purine nucleic acid-related substance contained. The composition for reducing skin dullness comprises a purine nucleic acid-related substance and a pharmaceutically or cosmetically acceptable carrier, and exhibits an excellent effect of reducing skin dullness due to the action of the purine nucleic acid-related substance contained.

  本发明提供了一种可有效改善黄褐斑的组合物和一种可有效减轻皮肤暗沉的组合物。 用于改善黄褐斑的组合物包括一种嘌呤核酸相关物质和一种药学上或化妆品上可接受的载体，由于所含嘌呤核酸相关物质的作用，该组合物具有极佳的改善黄褐斑的效果。 减少皮肤暗沉的组合物包含一种嘌呤核酸相关物质和一种药学上或化妆品上可接受的载体，由于所含嘌呤核酸相关物质的作用，该组合物具有极佳的减少皮肤暗沉的效果。
• Composition for improving melasma and composition for reducing skin dullness
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP2517712A1

  公开（公告）日：2012-10-31

  The present invention provides a cosmetic composition that can effectively improve melasma and a cosmetic composition that can effectively reduce skin dullness. The cosmetic composition for improving melasma comprises a purine nucleic acid-related substance and a cosmetically acceptable carrier, and exhibits an excellent melasma improving effect due to the action of the purine nucleic acid-related substance contained. The cosmetic composition for reducing skin dullness comprises a purine nucleic acid-related substance and a cosmetically acceptable carrier, and exhibits an excellent effect of reducing skin dullness due to the action of the purine nucleic acid-related substance contained.

  本发明提供了一种可有效改善黄褐斑的化妆品组合物和一种可有效减轻皮肤暗沉的化妆品组合物。 用于改善黄褐斑的化妆品组合物由一种嘌呤核酸相关物质和一种化妆品可接受载体组成，由于所含嘌呤核酸相关物质的作用，该组合物具有极佳的改善黄褐斑的效果。减少皮肤暗沉的化妆品组合物由嘌呤核酸相关物质和化妆品可接受载体组成，由于所含嘌呤核酸相关物质的作用，减少皮肤暗沉的效果极佳。