Arginine stearate | 32945-27-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Arginine stearate
• 英文别名: (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;octadecanoic acid
• CAS: 32945-27-0
• 化学式: C24H50N4O4
• 分子量: 458.7
• InChiKey: ALYQTSXGWBNEQC-VWMHFEHESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.78
• 重原子数：
  32
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  165
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• EXTERNAL PREPARATION
  申请人：Lion Corporation

  公开号：EP1437119A1

  公开（公告）日：2004-07-14

  An external preparation characterized by comprising, as selected from gallic acid derivatives of the following formula (I), wherein R1 represents a hydrogen atom, an alkali metal, an alkaline earth metal, an ammonium salt, or an alkyl or alkenyl group having from 1 to 18 carbon atoms and R2, R3, and R4 independently represent a hydrogen atom, an hydroxyl group, an alkoxy group having from 1 to 18 carbon atoms, a polyoxyethylene group, a polyoxypropylene group, or a residue of a monosaccharide, a disaccharide, or an oligosaccharide; 90 wt% or over of one or more gallic acid derivatives (A) wherein two of R2, R3, and R4 in the formula (I) independently represent a residue of a monosaccharide, disaccharide, or oligosaccharide and from 0.001 wt% to less than 10 wt% of one or more gallic acid derivatives (B) wherein one of R2, R3, and R4 represents a residue of a monosaccharide, disaccharide, or oligosaccharide, each based on the total content of the gallic acid derivatives.

  一种外用制剂，其特征在于包括选自下式(I)的没食子酸衍生物、 其中 R1 代表氢原子、碱金属、碱土金属、铵盐或具有 1 至 18 个碳原子的烷基或烯基，R2、R3 和 R4 独立地代表氢原子、羟基、具有 1 至 18 个碳原子的烷氧基、聚氧乙烯基、聚氧丙烯基或单糖、二糖或寡糖的残基；90% 或以上的一种或多种没食子酸衍生物 (A)，其中式 (I)中 R2、R3 和 R4 的两个独立地代表单糖、二糖或寡糖的残基，以及 0.001 wt% 至小于 10 wt% 的一种或多种没食子酸衍生物 (B)，其中 R2、R3 和 R4 中的一个代表单糖、二糖或寡糖的残余物，每种都以没食子酸衍生物的总含量为基础。
• EMULSIFIED COMPOSITION
  申请人：Kao Corporation

  公开号：EP2452668A1

  公开（公告）日：2012-05-16

  The emulsion composition of the present invention contains (A) 0.001 to 10 wt.% of an organic compound having two or more hydroxyl groups, an inorganic value of 220 to 450, and an organic value of 300 to 1,000; (B) 0.001 to 10 wt.% of an organic compound having one hydroxyl group, an inorganic value of 100 to 200, and an organic value of 280 to 700; (C) 0.001 to 10 wt.% of a compound represented by formula (2): wherein R1 is a C4 to C30 hydrocarbon group; Z is a methylene group, a methine group, or an oxygen atom; X1, X2, X3 is a hydrogen atom, a hydroxyl group, or an acetoxy group; X4 is a hydrogen atom, an acetyl group, or a glyceryl group; each of R2 and R3 a hydrogen atom, a hydroxyl group, a hydroxymethyl group, or an acetoxymethyl group; R4 is a C5 to C60 hydrocarbon group; and R5 is a hydrogen atom or a hydrocarbon group containing 1 to 30 carbon atoms in total; (D) 0.00012 to 10 wt.% of at least one compound selected from the group consisting of a nonionic surfactant having a polyoxyethylene group and an HLB of 10 or higher, an ionic surfactant, and a sphingosine salt; (E) 0.003 to 15 wt.% of at least one compound selected from the group consisting of a sugar alcohol selected from the group consisting of erythritol, threitol, xylitol, and mannitol, a disaccharide, and a trisaccharide; and (F) water.

  本发明的乳液组合物含有 (A) 0.001 至 10 重量百分比的具有两个或两个以上羟基的有机化合物，无机值为 220 至 450，有机值为 300 至 1,000； (B) 0.001 至 10 重量百分比的有机化合物，具有一个羟基，无机物含量为 100 至 200，有机物含量为 280 至 700； (C) 0.001 至 10 重量百分比的式(2)所代表的化合物： 其中 R1 是 C4 至 C30 的烃基；Z 是亚甲基、亚甲基或氧原子；X1、X2、X3 是氢原子、羟基或乙酰氧基；X4 是氢原子、乙酰基或甘油基；R2和R3各自为氢原子、羟基、羟甲基或乙酰氧甲基；R4为C5至C60烃基；R5为氢原子或共含有1至30个碳原子的烃基； (D) 0.00012 至 10 重量％的至少一种选自以下组别的化合物：具有聚氧乙烯基团且 HLB 为 10 或更高的非离子表面活性剂、离子表面活性剂和鞘氨醇盐； (E) 0.003 至 15 重量百分比的至少一种化合物，该化合物选自由赤藓糖醇、 苏糖醇、木糖醇和甘露糖醇、二糖和三糖组成的组；以及 (F) 水。
• EMULSION COSMETIC COMPOSITION
  申请人：Kao Corporation

  公开号：EP2857000A1

  公开（公告）日：2015-04-08

  An emulsified cosmetic composition comprising the following ingredients (A), (B), (C), and (D): (A) 0.1% by weight or more and 15% by weight or less of at least one compound selected from the group consisting of a sphingosine or a salt thereof, a pseudo-sphingosine or a salt thereof, and an ionic surfactant, (B) at least one compound selected from the group consisting of a monoglyceryl di-fatty acid ester and a sorbitan di-fatty acid ester, (C) at least one compound selected from the group consisting of a ceramide, an alcohol having 12 to 22 carbon atoms, a monoglyceryl mono-C12 to C22 fatty acid ester, a mono-C12 to C22 alkyl glyceryl ether, and a sorbitan mono-C12 to C22 fatty acid ester, and (D) water, wherein in the ingredients (A), (B), and (C), (1) a weight ratio of (A) / ((B) + (C)) is 0.04 or more and 1 or less, (2) a mole fraction of (B) / ((B) + (C)) is 0.02 or more and 0.45 or less, and (3) a maximum mole fraction of one compound as a single component in the ingredient (B) and the ingredient (C) is 0.2 or more and 0.8 or less.

  一种乳化化妆品组合物，包含以下成分(A)、(B)、(C)和(D)： (A) 0.1%（以重量计）或更多、15%（以重量计）或更少的至少一种选自由鞘氨醇或其盐、假鞘氨醇或其盐和离子表面活性剂组成的组中的化合物， (B) 至少一种选自由单甘油二脂肪酸酯和山梨糖醇二脂肪酸酯组成的组中的化合物、(C) 至少一种选自由神经酰胺、具有 12 至 22 个碳原子的醇、单甘油单 C12 至 C22 脂肪酸酯、单 C12 至 C22 烷基甘油醚和山梨糖醇单 C12 至 C22 脂肪酸酯组成的组的化合物，以及 (D) 水，其中在成分（A）、（B）和（C）中，(1) (A) / ((B) + (C)) 的重量比为 0.04 或更高，1 或更低；(2) (B) / ((B) + (C)) 的摩尔分数为 0.02 或更高，0.45 或更低；(3) 成分(B)和成分(C)中作为单一成分的一种化合物的最大摩尔分数为 0.2 或更高，0.8 或更低。
• METHOD FOR PRODUCING COATING FILM FOR COSMETIC PREPARATION
  申请人：Kao Corporation

  公开号：EP3545941A1

  公开（公告）日：2019-10-02

  The present invention provides a method for forming a coating for a cosmetic, with which the adhesion between skin and a coating formed through electrostatic spraying can be increased. The method for forming a coating for a cosmetic of the present invention includes: a cosmetic applying step of applying a cosmetic containing 10 mass% or more of an oil, that is in a solid form at 20°C onto skin; and an electrostatic spraying step of electrostatically spraying a composition directly onto the skin, thereby forming a coating. The composition contains a component (a) and a component (b) below: (a) one or more volatile substances selected from the group consisting of water, alcohols, and ketones; and (b) a polymer having a coating formation ability.

  本发明提供了一种用于形成化妆品涂层的方法，通过该方法可以提高皮肤与通过静电喷涂形成的涂层之间的附着力。本发明的化妆品涂层形成方法包括：化妆品涂抹步骤，在 20°C 温度下将含有 10 质量%或更多油的固态化妆品涂抹到皮肤上；静电喷涂步骤，将组合物直接静电喷涂到皮肤上，从而形成涂层。组合物包含以下组分（a）和组分（b）：(a) 从水、醇和酮组成的组中选出的一种或多种挥发性物质；和 (b) 具有涂层形成能力的聚合物。
• MEDICAL SKIN EXTERNAL PREPARATION
  申请人：Maruho Co., Ltd.

  公开号：EP3549586A1

  公开（公告）日：2019-10-09

  An object of the present invention is mainly to provide a medical skin external preparation that is suitable for treating superficial skin infections, in particular, superficial skin infections accompanied by blister or erosion, etc. For example, the present invention can provide a medical skin external preparation containing 1-cyclopropyl-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid and/or a pharmaceutically acceptable salt thereof as an active ingredient, and an alcohol and/or a fatty acid having 12 or more carbon atoms.

  本发明的目的主要是提供一种适用于治疗浅表皮肤感染，特别是伴有水疱或糜烂等浅表皮肤感染的医用皮肤外用制剂。例如，本发明可以提供一种医用皮肤外用制剂，其中含有 1-环丙基-8-甲基-7-[5-甲基-6-（甲基氨基）-3-吡啶基]-4-氧代-1,4-二氢-3-喹啉羧酸和/或其药学上可接受的盐作为活性成分，以及具有 12 个或更多碳原子的醇和/或脂肪酸。