5-(4-哌啶基)戊酸 | 103272-56-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 5-(4-哌啶基)戊酸
• 英文名称: 5-[4]piperidyl-valeric acid
• 英文别名: 5-[4]Piperidyl-valeriansaeure；5-(4-Piperidyl)pentanoic Acid；5-piperidin-4-ylpentanoic acid
• CAS: 103272-56-6
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: FKILXKDRDQKKCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲醇 、 5-(4-哌啶基)戊酸 在 氯化亚砜 作用下， 生成 Methyl 5-(4-piperidyl)pentanoate
  参考文献：
  名称：

  Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors

  摘要：

  We report here the strategy used in our research group to find a new class of histone deacetylase (HDAC) inhibitors.A series of N-substituted 4-alkylpiperazine and 4-alkylpiperidine hydroxamic acids, corresponding to the basic structure of HDAC inhibitors (zinc binding moiety-linker-capping group) has been designed, prepared, and tested for HDAC inhibition.Linker length and aromatic capping group connection were systematically varied to find the optimal geometric parameters. A new series of submicromolar inhibitors was thus identified, which showed antiproliferative activity on HCT-116 colon carcinoma cells. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.02.085
• 作为产物：
  描述：

  5-oxo-5-(pyridin-4-yl)pentanoic acid 在 硫酸 作用下， 生成 5-(4-哌啶基)戊酸
  参考文献：
  名称：

  Lukes; Ferles, Collection of Czechoslovak Chemical Communications, 1959, vol. 24, p. 1297,1301

  摘要：

  DOI：

文献信息

• [EN] PIPERIDINYL COMPOUNDS THAT SELECTIVELY BIND INTEGRINS<br/>[FR] COMPOSES DE PIPERIDINYLE LIANT SELECTIVEMENT LES INTEGRINES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2004020435A1

  公开（公告）日：2004-03-11

  The invention is directed to piperidinyl compounds of formula (I) and (II) that selectively bind integrin receptors and methods for treating an integrin mediated disorder, wherein W, R2, Z and q are described in the application.

  这项发明涉及选择性结合整合素受体的式(I)和(II)的哌啶基化合物，以及治疗整合素介导的疾病的方法，其中W、R2、Z和q在申请中有描述。
• Benzoxazepine compounds, their production and use
  申请人：Yukimasa Hidefumi

  公开号：US20070117787A1

  公开（公告）日：2007-05-24

  This invention provides new benzoxazepine compounds represented by the formula: [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R 1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering cholesterol-level and lowering triglyceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.

  本发明提供了一种新的苯并噁唑化合物，其表示为以下式子：[其中R代表可选地取代羟基的低碳基，X代表可选地取代的氨基甲酰基或具有可去质子氢原子的可选地取代的杂环基，R1代表低碳基，W代表卤素原子]，具有降低胆固醇水平和降低甘油三酯水平的活性，适用于预防和治疗高脂血症。
• PIPERIDINYL COMPOUNDS THAT SELECTIVELY BIND INTEGRINS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1539739A1

  公开（公告）日：2005-06-15
• PIPERIDINYL TARGETING COMPOUNDS THAT SELECTIVELY BIND INTEGRINS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1718635A1

  公开（公告）日：2006-11-08
• [EN] PIPERIDINYL TARGETING COMPOUNDS THAT SELECTIVELY BIND INTEGRINS<br/>[FR] COMPOSES DE CIBLAGE DE PIPERIDINYLE QUI SE LIENT DE FACON SELECTIVE AUX INTEGRINES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005082889A1

  公开（公告）日：2005-09-09

  The present invention relates to the synthesis and biological application of piperidinoyl carboxylic acid integrin antagonists affinity moiety of Formula (I) and Formula (II). These affinity moieties may be used with imaging agents or liposomes to target cells that express the αvβ3, αvβ5, or αvβ6 integrin receptors. Wherein W, R2, Z and q are as described in the application.