| 4229-35-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 4229-35-0
• 化学式: C28H54NaO7S
• 分子量: 557.8
• InChiKey: UTWVENOYOROSRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.18
• 重原子数：
  37
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  7

安全信息

• 海关编码：
  2914509090

文献信息

• CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS
  申请人：Bapat Abhijit S.

  公开号：US20140364595A1

  公开（公告）日：2014-12-11

  The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; or (iv) (AFA) m″ -X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.

  该发明提供了由至少一种抗真菌剂或抗菌剂与至少一种连接剂和/或载体偶联形成的基于共轭的抗真菌或抗菌前药。这些前药的公式为：(i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; 或 (iv) (AFA) m″ -X，其中：AFA是抗真菌剂或抗菌剂；L是载体；X是连接剂；m范围从1到10；n范围从2到10；m′为1到10；p为1到10；n′为1到10；q为1到10，前提是q'和n不同时为1；m″为1到10。该发明还提供了包含基于共轭的前药的纳米粒子。此外，该发明还提供了以纳米粒子形式的非共轭抗真菌和抗菌剂。
• Particulate construct comprising polyhydroxyalkanoate and method for producing it
  申请人：——

  公开号：US20030194443A1

  公开（公告）日：2003-10-16

  The invention provides a particulate construct such as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation. The invention also provides a particulate construct such as microcapsules utilizing a highly functional polymer compound and incorporating oil phase and/or water phase in solid phase, and a producing method therefor. Furthermore, the invention provides a particulate construct such as microcapsules having a hollow structure of a single polymer membrane as the outer shell and capable of containing many bubbles in the fine particles, and a producing method capable of preparing such construct with a high reproducibility. According to the invention, a particulate construct such as microcapsules is formed with polyhydroxyalkanoate of a specified structure and a drug for a desired purpose, an oil phase and/or a water phase, or a gaseous phase is included in such construct.

  本发明提供了一种微粒构造物，例如包含药物的微胶囊，用作缓释制剂，不会出现实际上不可接受的初始爆发释放，但在一定时间内显示实际上可接受的零级释放，并提供了这种微粒构造物的制备方法，以及能够稳定地将药物纳入微粒构造物中，例如微胶囊的高药物含量的缓释制剂，以及这种制备方法。本发明还提供了一种利用高功能聚合物化合物并将油相和/或水相纳入固相的微粒构造物，以及其制备方法。此外，本发明还提供了一种具有单一聚合物膜的空心结构的微粒构造物，能够在细小的颗粒中包含许多气泡，并提供了一种能够高度重复制备这种构造物的制备方法。根据本发明，可使用具有特定结构的聚羟基烷酸酯和药物制备微粒构造物，该构造物中包含油相和/或水相或气态相。
• Coloring composition for color filters containing microencapsulated pigment composed of polyhydroxyalkanoate
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20030203458A1

  公开（公告）日：2003-10-30

  The invention provides coloring composition for color filters making use of a pigment, in which the dispersed state of the pigment is stable without using any surfactant, and so aggregation is hard to occur, and which permits formation of high-definition and high-quality images excellent in color rendition, transparency and contrast, and a simple production process thereof, by which the use of surfactants can be abolished, or the amount of surfactants used can be reduced to a great extent. The coloring composition for color filters is provided by using at least a coloring material obtained by coating at least part of surfaces of pigment particles with polyhydroxyalkanoate, and a dispersion medium for the coloring material.

  该发明提供了一种用于彩色滤光片的染色组合物，其中颜料的分散状态稳定，不需要使用任何表面活性剂，因此聚集很难发生，并且允许形成高清晰度和高质量的图像，具有出色的色彩再现度、透明度和对比度，以及简单的生产过程，通过该过程可以废除表面活性剂的使用，或者大大减少所使用的表面活性剂的数量。通过使用至少一种染色材料，该染色材料通过在颜料颗粒的至少一部分表面上涂覆聚羟基烷酸酯而获得，并且用于染色材料的分散介质。
• Pigment containing ink and production method thereof
  申请人：——

  公开号：US20030203987A1

  公开（公告）日：2003-10-30

  A micro-capsulated pigment containing pigment ink being excellent in density, fineness, transparency, and coloring and color rendering properties required for ink solutions and having excellent dispersibility and dispersion stability with time due to the reduced particle size is provided. At least a color material with at least part of the surfaces of pigment particles covered with polyhydroxyalkanoate, and a medium for dispersion of the color material are used to obtain the pigment ink.

  提供了一种微胶囊化颜料，其中包含颜料油墨，其具有油墨溶液所需的密度、细度、透明度、着色和色彩还原性，由于粒子尺寸的减小，具有优异的分散性和稳定性。使用至少一种颜料材料，其中颜料颗粒的至少一部分表面被聚羟基脂肪酸酯覆盖，以及用于分散颜料材料的介质来获得颜料油墨。
• Liposome coated with polyhydroxyalkanoate and production method thereof
  申请人：——

  公开号：US20030113368A1

  公开（公告）日：2003-06-19

  To provide a structure that has both drug holding capability and sustained releasability a liposome and mechanical strength of polyhydroxyalkanoate, is excellent in holding capability for hydrophilic drugs and other water-soluble substances as well as liphophilic drugs and other hydrophobic substances, and is capable of controlling the sustained releasability. To coat with polyhydroxyalkanoate at least part of the outer wall of the liposome.

  为了提供既具有药物持有能力又具有持续释放能力的结构，可以使用磷脂体和聚羟基脂肪酸酯的机械强度，这种结构对于亲水性药物和其他水溶性物质以及亲脂性药物和其他疏水性物质的持有能力非常出色，并且可以控制持续释放能力。可以在磷脂体的外壳至少部分涂覆聚羟基脂肪酸酯。