1-tosylazepane | 17721-45-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-tosylazepane
• 英文别名: 1-((4-Methylphenyl)sulfonyl)azepane；1-(4-methylphenyl)sulfonylazepane
• CAS: 17721-45-8
• 化学式: C₁₃H₁₉NO₂S
• mdl: MFCD00441934
• 分子量: 253.365
• InChiKey: WYGOYZNQMXVUEJ-UHFFFAOYSA-N

物化性质

• 熔点：
  72-74 °C
• 沸点：
  383.4±35.0 °C(Predicted)
• 密度：
  1.157±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-tosylazepane 在 氢氧化钾 作用下， 生成 环己亚胺
  参考文献：
  名称：

  On the generalization of the form identification and skew detection problem

  摘要：

  A new method is proposed to solve the document identification and skew detection problem. It can be applied to a widely used subclass of documents which resemble in style an application form. Unlike other approaches, we make no assumptions about the nature and/or style of the printed form. An attempt is made to solve the problem in the most general sense. The method presented here does not rely on any special features such as patterns of line crossings, or dominant lines, or even special symbols found only on specially designed forms. The Power Spectral Density of the horizontal projection profile of the form is used as a shift invariant feature vector. The Karhunen-Loeve transform is employed to de-correlate and reduce the length of the feature vectors in the training set. Training is done in such a way that no rotations of the unknown form are necessary during recognition. The eigenvectors of the covariance matrix of the power spectral densities for the training set, along with learning vector quantization, were used for training, and the Euclidean distance, for recognition. A limitation related to the amount of skew that the system can handle is alleviated with the use of a known skew detection method. (C) 2001 Pattern Recognition Society. Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0031-3203(01)00030-9
• 作为产物：
  描述：

  N-tosyl-6-bromohexylamine 在 四甲基氢氧化铵 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 48.0h， 生成 1-tosylazepane
  参考文献：
  名称：

  Galli, Carlo; Gargano, Patrizia; Mandolini, Luigi, Gazzetta Chimica Italiana, 1986, vol. 116, # 11, p. 653 - 658

  摘要：

  DOI：

文献信息

• N Alkylation of Tosylamides Using Esters as Primary and Tertiary Alkyl Sources: Mediated by Hydrosilanes Activated by a Ruthenium Catalyst
  作者：Takashi Nishikata、Hideo Nagashima

  DOI：10.1002/anie.201201426

  日期：2012.5.29

  Select your group: Either a primary or tertiary alkyl group can be selectively introduced onto the nitrogen atom of tosylamides in a ruthenium‐catalyzed reaction employing hydrosilanes through a judicious choice in the esters that serve as the alkyl source (see scheme; Ts= 4‐toluenesulfonyl). These N‐alkylation reactions are useful for construction of naturally occurring azacyclic skeletons.

  选择您的基团：在使用氢硅烷的钌催化反应中，可以明智地选择用作烷基源的酯，将伯烷基或叔烷基选择性引入甲苯磺酰胺的氮原子上（参见方案; Ts = 4-甲苯磺酰基）。这些N烷基化反应可用于构建天然存在的氮杂环骨架。
• RUTHENIUM POLYMERISATION CATALYSTS
  申请人：UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS

  公开号：US20140228563A1

  公开（公告）日：2014-08-14

  Cis and trans ruthenium complexes that can be used as catalysts for ring opening metathesis polymerisation (ROMP) are described. The complexes are generally square pyramidal in nature, having two anionic ligands X. Corresponding cationic complexes where one or both of the anionic ligands X are replaced by a non-co-ordinating anionic ligand are also described. Polymers such as polydicyclopentadiene (PDCPD) can be prepared using the catalysts.

  描述了可以用作环开环醚交换聚合（ROMP）催化剂的顺式和反式钌配合物。这些配合物通常具有两个阴离子配体X，本质上是方锥形的。还描述了相应的阳离子配合物，其中一个或两个阴离子配体X被非配位阴离子配体取代。可以使用这些催化剂制备聚二环戊二烯（PDCPD）等聚合物。
• Tandem Ring-Closing Metathesis/Transfer Hydrogenation: Practical Chemoselective Hydrogenation of Alkenes
  作者：Timothy Connolly、Zhongyu Wang、Michael A. Walker、Ivar M. McDonald、Kevin M. Peese

  DOI：10.1021/ol5019739

  日期：2014.9.5

  chemoselective transfer hydrogenation of alkenes using ruthenium metathesis catalysts is presented. Of great practicality, the transfer hydrogenation reagents can be added directly to a metathesis reaction and effect hydrogenation of the product alkene in a single pot at ambient temperature without the need to seal the vessel to prevent hydrogen gas escape. The reduction is applicable to a range of alkenes and

  提出了使用钌复分解催化剂的烯烃的操作简单的化学选择性转移氢化。实用性很强，可以将转移氢化试剂直接添加到复分解反应中，并在室温下在一个罐中对产物烯烃进行氢化，而无需密封容器以防止氢气逸出。还原适用于各种烯烃，并且可以在芳基卤化物和苄基存在下进行，这是钯催化氢化的显着缺点。介绍了范围和机械方面的考虑。
• Iodine-catalyzed expeditious synthesis of sulfonamides from sulfonyl hydrazides and amines
  作者：Sirilata Yotphan、Ladawan Sumunnee、Danupat Beukeaw、Chonchanok Buathongjan、Vichai Reutrakul

  DOI：10.1039/c5ob02075a

  日期：——

  A new synthesis of sulfonamides has been developed via an iodine-catalyzed sulfonylation of amines with arylsulfonyl hydrazides. This metal-free strategy employs readily accessible and easy to handle starting materials, catalysts and oxidants, and can be easily conducted under mild conditions, providing a convenient access to a wide range of sulfonamides in moderate to excellent yields within a short

  通过碘与芳基磺酰肼的胺催化磺酰化反应，开发了一种新的磺酰胺合成方法。这种无金属的策略采用易于获得且易于处理的起始原料，催化剂和氧化剂，并且可以在温和条件下轻松进行，从而在短时间内即可以中等到极好的收率方便地获得各种磺酰胺。
• Photoinduced Direct Cyanation of C(sp3)-H Bonds
  作者：Masayuki Inoue、Tamaki Hoshikawa、Shun Yoshioka、Shin Kamijo

  DOI：10.1055/s-0032-1318325

  日期：——

  reacts with tosyl cyanide to afford the corresponding nitrile in a highly efficient manner. The present methodology is widely applicable to various starting materials including ethers, alcohols, amine derivatives, alkanes, and alkylbenzenes. This newly developed C–H cyanation protocol provides a powerful tool for selective one-carbon elongation for the construction of architecturally complex molecules

  摘要 已经开发了将不反应的C（sp 3）-H键直接转化为C（sp 3）-CN键的通用实用合成方案。通过光激发的二苯甲酮开始进行C–H键的均质裂解，随后生成的碳自由基与甲苯磺酰氰反应，以高效方式提供相应的腈。本方法学可广泛应用于各种起始原料，包括醚，醇，胺衍生物，烷烃和烷基苯。这种新开发的C–H氰化方案为构建结构复杂的分子提供了一种强大的工具，可以选择性地进行一碳延伸。 已经开发了将不反应的C（sp 3）-H键直接转化为C（sp 3）-CN键的通用实用合成方案。通过光激发的二苯甲酮开始进行C–H键的均质裂解，随后生成的碳自由基与甲苯磺酰氰反应，以高效方式提供相应的腈。本方法学可广泛应用于各种起始原料，包括醚，醇，胺衍生物，烷烃和烷基苯。这种新开发的C–H氰化方案为构建结构复杂的分子提供了一种强大的工具，可以选择性地进行一碳延伸。