2-O-α-D-glucopyranosyl-D-erythorbic acid | 154160-11-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-O-α-D-glucopyranosyl-D-erythorbic acid
• 英文别名: 2-o-a-d-Glucopyranosyl-l-ascorbic acid；(2R)-2-[(1R)-1,2-dihydroxyethyl]-3-hydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2H-furan-5-one
• CAS: 154160-11-9
• 化学式: C₁₂H₁₈O₁₁
• 分子量: 338.268
• InChiKey: MLSJBGYKDYSOAE-WGCHHNRKSA-N

物化性质

• 沸点：
  785.6±60.0 °C(Predicted)
• 密度：
  1.83±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  186
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  维生素 C 、 蔗糖 在 Bifidobacterium breve sucrose phosphorylase L₃₄₃F 作用下， 生成 2-O-α-D-glucopyranosyl-D-erythorbic acid
  参考文献：
  名称：

  蔗糖磷酸化酶生物催化生产 2-O-α-d-吡喃葡萄糖基-l-抗坏血酸的工艺相关杂质鉴定及相应控制策略

  摘要：

  2- O -α- d -Glucopyranosyl - l -ascorbic acid (AA-2G) 具有显着的稳定性和良好的生物活性，是l-抗坏血酸的理想替代品，可方便地应用于化妆品、食品和医药等领域字段。然而，杂质识别和控制是 AA-2G 制造过程中的重要程序。本研究评估了由蔗糖磷酸化酶 (SPase) 合成的 AA-2G 的生产流程。首先，观察到三种未知的工艺相关杂质，进一步鉴定为 3- O -α - d-吡喃葡萄糖基-l-抗坏血酸（杂质 I）、2 - O -α- d-吡喃葡萄糖基-l-脱氢抗坏血酸（杂质 II）和 13 - O -α - d-吡喃葡萄糖基-2- O - α-d-吡喃葡萄糖基-l-抗坏血酸（杂质III），分别。其次，阐明了杂质的综合形成途径，并提出了控制每种杂质的具体策略。具体来说，通过微调反应条件，可以将杂质I的含量降低50%。通过应用低浓度的碱也实现了无杂质

  DOI：

  10.1021/acs.jafc.2c00881

文献信息

• Immunoassay method and immunochromatographic kit
  申请人：TANAKA KIKINZOKU KOGYO K.K.

  公开号：US10591469B2

  公开（公告）日：2020-03-17

  The present invention is intended to provide an immunoassay method that enables an immunoassay with high sensitivity at a high development rate without causing aggregation of insoluble carriers or non-specific reaction while improving test efficiency and reducing labor. The present invention relates to an immunoassay method that uses a test device, and the method includes: extracting an antigen of a detection target in an analyte with an extraction agent; and detecting the detection target with a detection reagent capable of binding the antigen. The extraction agent is a nitrous acid generated on the test device by a contact reaction between a nitrite salt and a heterocyclic compound having at least one skeleton selected from the group consisting of a cyclic ester, a cyclic amide, and a cyclic imide.

  本发明旨在提供一种免疫测定方法，使免疫测定在高显影率下具有高灵敏度，不会引起不溶性载体聚集或非特异性反应，同时提高检测效率，减少劳动力。本发明涉及一种使用检测装置的免疫测定方法，该方法包括：用提取剂提取被分析物中检测目标的抗原；用能够结合抗原的检测试剂检测检测目标。萃取剂是通过亚硝酸盐和杂环化合物之间的接触反应在测试装置上生成的亚硝酸，杂环化合物的至少一个骨架选自环酯、环酰胺和环亚胺组成的组。
• Highly efficient and regioselective production of an erythorbic acid glucoside using cyclodextrin glucanotransferase from Thermoanaerobacter sp. and amyloglucosidase
  作者：Akihiro Tai、Yuji Iwaoka、Hideyuki Ito

  DOI：10.1016/j.molcatb.2013.03.011

  日期：2013.8

  In order to continuously supply erythorbic acid (EA) for long-term cell cultures, we synthesized a stable EA derivative, 2-O-alpha-D-glucopyranosyl-D-erythorbic acid (EA-2G), as a useful tool for analyzing the biological function of EA. The specific and efficient production process of EA-2G consisted of two steps: transglycosylation by cyclodextrin glucanotransferase (CGTase) from Thermoanaerobacter sp. and hydrolysis by amyloglucosidase from Aspergillus niger. EA-2G was regioselectively formed by CGTase using EA and gamma-cyclodextrin in pH 4.0 acetate buffer at 40 degrees C for 24h. It seemed that several EA-2-oligoglucosides were also formed in this reaction mixture. Additional hydrolysis at 60 degrees C for 2 h of the reaction mixture by glucoamylase resulted in efficient production of EA-2G. EA-2G was obtained in two steps in 49.1% overall yield from EA. (C) 2013 Elsevier B.V. All rights reserved.
• COMPOSITIONS OF VITAMIN C DERIVATIVE AND PORTULACA EXTRACT
  申请人：Zolotarsky Yelena

  公开号：US20120189564A1

  公开（公告）日：2012-07-26

  Compositions including Portulaca extract and a vitamin C derivative selected from ascorbyl glucoside (ASG), magnesium ascorbyl phosphate an ethyl ascorbic acid. The compositions can be employed as an inhibitor to melanin formation and used as an additive to a cosmetic or pharmaceutical formulation.
• IMMUNOASSAY METHOD AND IMMUNOCHROMATOGRAPHIC KIT
  申请人：TANAKA KIKINZOKU KOGYO K.K.

  公开号：US20180209970A1

  公开（公告）日：2018-07-26

  The present invention is intended to provide an immunoassay method that enables an immunoassay with high sensitivity at a high development rate without causing aggregation of insoluble carriers or non-specific reaction while improving test efficiency and reducing labor. The present invention relates to an immunoassay method that uses a test device, and the method includes: extracting an antigen of a detection target in an analyte with an extraction agent; and detecting the detection target with a detection reagent capable of binding the antigen. The extraction agent is a nitrous acid generated on the test device by a contact reaction between a nitrite salt and a heterocyclic compound having at least one skeleton selected from the group consisting of a cyclic ester, a cyclic amide, and a cyclic imide.
• [EN] ANTIVIRAL COMPOSITIONS COMPRISING LIPOSOME-ENCAPSULATED ASCORBYL GLUCOSIDE AND NATURAL EXTRACTS<br/>[FR] COMPOSITIONS ANTIVIRALES COMPRENANT DU GLUCOSIDE D'ASCORBYLE ENCAPSULÉ DANS DES LIPOSOMES ET DES EXTRAITS NATURELS
  申请人：BIONEXT LABS LTD

  公开号：WO2021234687A1

  公开（公告）日：2021-11-25

  Antiviral liposomal compositions comprising ascorbyl 2-glucoside (AA2G) and other active ingredients including propolis extract and other natural plant extracts, use thereof as an effective medicament, prophylactic, or nutritional supplement against viral infections in general and for treating and or preventing coronavirus disease 2019 (COVID-19) in particular, and methods of preparing such antiviral compositions.