9,10-dioxo-9,10-dihydro-2,6-anthracenedisulfonyl dichloride | 36003-87-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 9,10-dioxo-9,10-dihydro-2,6-anthracenedisulfonyl dichloride
• 英文别名: anthraquinone-2,6-disulfonyl chloride；2,6-anthraquinonedisulfonyl chloride；anthraquinone-2,6-disulfonylchloride；9,10-dioxo-9,10-dihydro-anthracene-2,6-disulfonyl chloride；9,10-Dioxo-9,10-dihydro-anthracen-2,6-disulfonylchlorid；Anthrachinon-disulfonsaeure-(2.6)-dichlorid；9,10-Anthracenedione, 2,6-bis(chlorosulfonyl)-；9,10-dioxoanthracene-2,6-disulfonyl chloride
• CAS: 36003-87-9
• 化学式: C₁₄H₆Cl₂O₆S₂
• 分子量: 405.236
• InChiKey: CZNYYPMFWGMKRC-UHFFFAOYSA-N

物化性质

• 沸点：
  620.5±55.0 °C(Predicted)
• 密度：
  1.743±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  119
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  9,10-dioxo-9,10-dihydro-2,6-anthracenedisulfonyl dichloride 在 盐酸 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 40.0h， 生成 N,N'-bis(4-aminobutyl)-2,6-anthraquinonedisulfonamide dihydrochloride
  参考文献：
  名称：

  Cationic Anthraquinone Derivatives as Catalytic DNA Photonucleases: Mechanisms for DNA Damage and Quinone Recycling

  摘要：

  Ammonium-substituted anthraquinone derivatives have been found to catalyze DNA cleavage upon irradiation with 350 nm light. Picosecond laser spectroscopy demonstrates that the excited quinones react with DNA by two separate oxidative pathways: electron transfer from a nearby base and hydrogen atom abstraction from the deoxyribose component of the nucleic acid backbone. Photo-oxidation of DNA by either pathway yields the one-electron-reduced form of the quinone as a byproduct. Back electron transfer from the reduced quinone to the oxidized base is the predominant decay path for the reduced quinone formed by the electron transfer pathway while that formed by hydrogen atom abstraction is converted back to the ground-state, fully oxidized form by reduction of molecular oxygen. The resulting superoxide anion is detected by its reduction of cytochrome c. Comparison of the spectroscopic data for two quinones with significantly different cleavage efficiencies suggests that DNA cleavage by these quinone reagents results from the hydrogen-abstraction chemistry. The laser experiments further indicate that the quinone completes one cycle of excitation, oxidation of DNA, and reduction of oxygen within 10 mu s, illustrating the potential utility of these agents for double-stranded cleavage of DNA.

  DOI：

  10.1021/ja00101a005
• 作为产物：
  描述：

  disodium 9,10-anthraquinone-2,6-disulfonate 在 氯化亚砜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 9,10-dioxo-9,10-dihydro-2,6-anthracenedisulfonyl dichloride
  参考文献：
  名称：

  [EN] DEGRADATION ACCELERATOR FOR POLYMERS AND POLYMER ARTICLE COMPRISING IT
  [FR] ACCÉLÉRATEUR DE DÉGRADATION POUR DES POLYMÈRES ET ARTICLE POLYMÈRE LE COMPRENANT

  摘要：

  公开了一种改善天然和/或合成聚合物或由这些聚合物制成的聚合物制品在光线和/或热量和/或湿度作用下降解的方法，包括将式(I)的化合物并入所述天然和/或合成聚合物中：式(I)；其中m为1或2，n为1至100，X从特定苯基酮衍生物中选择，R，R1，R2分别从特定残基列表中选择；所述式(I)的新化合物和在存在光线和/或热量和/或湿度时具有改善降解性能的聚合物制品由包括以下成分的组合物制成：A) 天然和/或合成聚合物和B) 一种降解加速剂，该加速剂是所述式(I)的化合物。

  公开号：

  WO2009016083A1

文献信息

• FLUORENES AND ANTHRACENES THAT INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS
  申请人：——

  公开号：US20040019042A1

  公开（公告）日：2004-01-29

  Compounds of formula (I) 1 are novel P2X 3 and P2X 2 /P2X 3 containing receptor antagonists and are useful in treating pain, urinary incontinence, and bladder overactivity.

  式(I)1的化合物是新型的含有P2X3和P2X2/P2X3受体拮抗剂，可用于治疗疼痛、尿失禁和膀胱过度活动。
• DIMERIC IAP INHIBITORS
  申请人：STRAUB Christopher Sean

  公开号：US20110206690A1

  公开（公告）日：2011-08-25

  The present invention provides compounds of formula M-L-M′ (where M and M′ are each independently a monomeric moiety of Formula (I) and L is a linker). The dimeric compounds have been found to be effective in promoting apoptosis in rapidly dividing cells.

  本发明提供了公式M-L-M′的化合物（其中M和M′分别是公式（I）中的单体基团，L是连接物）。已发现二聚化合物在促进快速分裂细胞凋亡方面具有有效性。
• Oxygen scavenging compositions
  申请人：——

  公开号：US20040099840A1

  公开（公告）日：2004-05-27

  Epoxy anthraquinonesulfonamide compounds are disclosed having the Formula (I) wherein X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 and X 8 are each independently selected from H, OH, NH 2 , C 1 -C 40 alkyl, C 1 -C 40 alkoxy, C 1 C 40 alkanoyl, C 1 -C 40 alkanol, C 1 -C 40 alkylether, C 1 -C 40 alkylthio, C 1 -C 40 alkylamino, C 1 -C 40 alkanolether, C 1 -C 40 alkylaminoether, C 1 -C 40 alkylsulfonyl, C 1 -C 40 alkyl sulfonanmido, epoxy sulfonamido substituents, and sulfonate substituents, with the proviso that at least one of X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 and X 8 is an epoxy sulfonamido substituent, and salts thereof. The compounds and reaction products thereof may be used in oxygen scavenging compositions. 1

  公开了具有式（I）的环氧蒽醌磺酰胺化合物，其中X1、X2、X3、X4、X5、X6、X7和X8各自独立地选择自H、OH、NH2、C1-C40烷基、C1-C40烷氧基、C1C40酰基、C1-C40醇基、C1-C40烷醚基、C1-C40烷硫基、C1-C40烷基氨基、C1-C40醇基醚、C1-C40烷基氨基醚、C1-C40烷基磺酰基、C1-C40烷基磺酰胺基、环氧磺酰胺基取代基和磺酸基取代基，但至少其中一个是环氧磺酰胺基取代基，并且其盐。这些化合物及其反应产物可用于氧气清除组合物。
• [EN] MONO- AND DISULFO-SUBSTITUTED ANTHRAQUINONES AND THEIR USE FOR THE TREATMENT OF BONE MATRIX DISORDERS<br/>[FR] ANTRAQUINONES MONO- ET DISULFOSUBSTITUES ET LEUR UTILISATION POUR TRAITER DES ANOMALIES DE LA MATRICE OSSEUSE
  申请人：BOONVILLE LIMITED

  公开号：WO1997000675A1

  公开（公告）日：1997-01-09

  (EN) The use of the compounds of formula (I), wherein the groups are as defined in the disclosure, for the preparation of medicaments for the treatment of pathologies in which the erosion of the cartilaginous and bone matrix occurs.(FR) On utilise des composés de formule (I), dans laquelle les groupes ont la définition donnée dans la description, pour préparer des médicaments thérapeutiques d'états pathologiques qui se caractérisent par l'érosion de la matrice cartilagineuse et osseuse.

  使用公式（I）中定义的基团，其中基团的定义如披露所述，用于制备治疗软骨和骨基质侵蚀病理的药物。
• Self-reducing anthraquinone compounds
  申请人：——

  公开号：US20040175314A1

  公开（公告）日：2004-09-09

  A method of scavenging oxygen in an atmosphere or liquid comprising the steps of: (i) treating an anthraquinone compound according to the formula: (I) wherein X1-X4 and R1-R4 are as defined in the claims, with predetermined conditions so as to reduce the anthraquinone compound to a reduced form oxidizable by oxygen; and ii) exposing the atmosphere or liquid to said compound; such that at least a portion of teh oxygen in teh atmosphere or liquid is removed through oxidation of the reduced form of the anthraquinone compound, and wherein steps i) and ii) may be carried out in either order. 1

  一种清除大气或液体中氧气的方法，包括以下步骤：（i）按照公式（I）中定义的X1-X4和R1-R4的预定条件处理蒽醌化合物，使其被还原为可被氧气氧化的还原形式；和（ii）将大气或液体暴露于该化合物中，以便通过氧化蒽醌化合物的还原形式至少去除大气或液体中的一部分氧气，其中步骤i）和ii）可以以任何顺序进行。