cyclo-Leu-Val | 15136-24-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cyclo-Leu-Val
• 英文别名: cyclo(L-Val-L-Leu)；cyclo(L-Leu-L-Val)；(3S,6S)-3-(2-Methylpropyl)-6-(propan-2-yl)piperazine-2,5-dione；(3S,6S)-3-(2-methylpropyl)-6-propan-2-ylpiperazine-2,5-dione
• CAS: 15136-24-0
• 化学式: C₁₁H₂₀N₂O₂
• 分子量: 212.292
• InChiKey: UPOUGDHEEGKEGS-IUCAKERBSA-N

物化性质

• 沸点：
  436.4±38.0 °C(Predicted)
• 密度：
  0.989±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

制备方法与用途

Cyclo(L-Leucyl-L-Valyl)能抑制寄生曲霉(Aspergillus parasiticus)产生黄曲霉毒素，并且可以抑制与黄曲霉毒素相关的基因转录，如aflR、hexB、pksL1和dmtA。

反应信息

• 作为反应物：
  描述：

  cyclo-Leu-Val 在 盐酸 作用下， 反应 2.5h， 生成 L-亮氨酸盐酸盐
  参考文献：
  名称：

  Bull; Davies; Garner, Journal of the Chemical Society. Perkin Transactions 1 (2001), 2001, # 24, p. 3281 - 3287

  摘要：

  DOI：
• 作为产物：
  描述：

  (3S,6S)-N,N'-bis(4-methoxybenzyl)-3-isopropyl-6-isobutylpiperazine-2,5-dione 在 ammonium cerium(IV) nitrate 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以90%的产率得到cyclo-Leu-Val
  参考文献：
  名称：

  Bull; Davies; Garner, Journal of the Chemical Society. Perkin Transactions 1 (2001), 2001, # 24, p. 3281 - 3287

  摘要：

  DOI：

文献信息

• Acetic acid-catalyzed diketopiperazine synthesis.
  作者：KENJI SUZUKI、YUSUKE SASAKI、NOBUYOSHI ENDO、YUICHI MIHARA

  DOI：10.1248/cpb.29.233

  日期：——

  Optically pure diketopiperazines were obtained in good yields when dipeptide esters were refluxed in 2-butanol containing 0.1 M acetic acid for 3 hours. When prolyl-amino acid ester was used as the starting material, 1 to 2 M acetic acid was the most effective concentration.

  当二肽酯在含有0.1 M醋酸的2-丁醇中回流3小时时，得到了光学纯的二酮哌嗪，产率良好。当使用脯氨酰氨基酸酯作为起始材料时，1至2 M醋酸是最有效的浓度。
• Cyclo(dipeptide)s as low-molecular-mass gelling agents to harden organic fluids
  作者：Kenji Hanabusa、Yoshimitsu Matsumoto、Toru Miki、Toshiki Koyama、Hirofusa Shirai

  DOI：10.1039/c39940001401

  日期：——

  Cyclic dipeptides consisting of diverse amino acids can cause physical gelation in a wide variety of organic fluids, including edible oils, glyceryl esters, alcohols and aromatic molecules; the gelation phenomenon is characterized by minimum gel concentration, FTIR spectroscopy, transmission electron microscopy, and X-ray diffraction.

  由多种氨基酸组成的环状二肽可在多种有机流体（包括食用油、甘油酯、酒精和芳香族分子）中引起物理凝胶化；凝胶化现象可通过最小凝胶浓度、傅里叶变换红外光谱、透射电子显微镜和 X 射线衍射来表征。
• Patient interface
  申请人：KONINKLIJKE PHILIPS N.V.

  公开号：US10751495B2

  公开（公告）日：2020-08-25

  The present invention relates to patient interfaces optically indicating a user that a member of the patient interface needs to be replaced due to wear. In particular, the present invention relates to a member for patient interface which includes at least one functional material having a predefined functionality and at least one indicator wherein the concentration of the at least one indicator in the member correlates with the predefined functionality of the at least one functional material.

  本发明涉及病人界面，通过光学方式向用户指示病人界面的部件因磨损而需要更换。特别是，本发明涉及一种病人界面部件，它包括至少一种具有预定功能的功能材料和至少一种指示器，其中部件中至少一种指示器的浓度与至少一种功能材料的预定功能相关。
• Solution casting method and polymer film
  申请人：Sugiura Masaru

  公开号：US20050077648A1

  公开（公告）日：2005-04-14

  A solvent in which dichloromethane is mixed with alcohol as a poor solvent is used for preparing a dope. Alcohol is supplied to the dope in a inline pipe to mix with a static mixer, such as a casting dope in which a composition of alcohol is increased. The temperature of the rotary drum is adjusted to −7° C. The casting dope is fed from a casting die to the rotary drum so as to form a casting film whose thickness is 40 μm. Since the content of alcohol is high and a storage modulus of the cooled casting film is at least 150 thousands Pa, the peeling defect does not occur, and the stretch is reduced as far as possible. A gel-like film is dried by a tenter type drying device, and stretched such that the stretch ratio is at most 110%. The produced film is thin and excellent in a surface condition and optical isotropy.

  二氯甲烷与作为劣质溶剂的酒精混合的溶剂用于制备涂料。酒精通过内联管道供应到涂料中，与静态混合器混合，如增加酒精成分的铸造涂料。将浇注料从浇注模具送入旋转滚筒，以形成厚度为 40 μm 的浇注膜。由于酒精含量高，冷却后的浇注膜的储存模量至少为 15 万帕，因此不会出现剥离缺陷，拉伸也尽可能减小。凝胶状薄膜由拉幅机干燥，拉伸率不超过 110%。生产出的薄膜很薄，表面状态和光学各向同性都很好。
• Care and/or make-up cosmetic composition structured with silicone polymers and organogelling agents, in rigid form
  申请人：Ferrari Veronique

  公开号：US20050245673A1

  公开（公告）日：2005-11-03

  The invention relates to a care and/or make-up cosmetic composition comprising a liquid fatty phase comprising at least one silicone oil, structured with a gelling system comprising 1) at least one polymer having a weight-average molecular mass ranging from 500 to 500 000, containing at least one moiety comprising: at least one polyorganosiloxane group consisting of 1 to 1 000 organosiloxane units in the chain of the moiety or in the form of a graft, and at least two groups capable of establishing hydrogen interactions, the polymer being solid at room temperature and soluble in the liquid fatty phase at a temperature of 25 to 250° C., and 2) at least one non-polymeric organogelling agent.

  本发明涉及一种护理和/或化妆用化妆品组合物，该组合物包含至少一种由硅油组成的液态脂肪相，其胶凝剂体系的结构包括：1）至少一种聚合物，其重量平均分子质量在 500 至 500 000 之间，含有至少一个分子，该分子包括：至少一个聚有机硅氧烷基团，该基团在分子链中或以接枝形式存在，由 1 至 1 000 个有机硅氧烷单元组成；以及至少两个能够建立氢相互作用的基团：至少一个聚有机硅氧烷基团，该基团在该分子链中或以接枝的形式由 1 至 1 000 个有机硅氧烷单元组成，以及至少两个能建立氢相互作用的基团，该聚合物在室温下为固态，在 25 至 250 摄氏度的温度下可溶于液态脂肪相。,2) 至少一种非聚合物有机胶凝剂。