1-phenyl-1,1-dimethoxy-2-(1,1,2,2-tetrafluoroethoxy)ethane | 1369761-86-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenyl-1,1-dimethoxy-2-(1,1,2,2-tetrafluoroethoxy)ethane
• 英文别名: [1,1-Dimethoxy-2-(1,1,2,2-tetrafluoroethoxy)ethyl]benzene
• CAS: 1369761-86-3
• 化学式: C₁₂H₁₄F₄O₃
• 分子量: 282.235
• InChiKey: IHRZFQPNFHRCNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-phenyl-1,1-dimethoxy-2-(1,1,2,2-tetrafluoroethoxy)ethane 在 盐酸 、 N-溴代丁二酰亚胺(NBS) 、 氯化亚砜 、 水 、 对甲苯磺酸 、 potassium hydroxide 作用下， 以 1,4-二氧六环 、 四氯化碳 、 乙醇 、 二氯甲烷 为溶剂， 反应 62.0h， 生成 3-phenyl-2-(1,1,2,2-tetrafluoroethoxy)benzo[4,5]imidazo[2,1-b]thiazole
  参考文献：
  名称：

  Efficient synthesis of 5′-fluoroalkoxythiazoles via α-bromo-α-fluoroalkoxyacetophenones Hantzsch type cyclization with thioureas or thioamides

  摘要：

  Novel alpha-fluoroalkoxyacetophenones were synthesized by addition of the readily available 2,2-dimethoxy-2-phenylethanol to fluoroolefins. alpha-Bromination yielded alpha-bromo-alpha-fluoroalkoxyacetophenones, which on treatment with thioureas or thioamides gave thiazoles with fluoroalkoxy groups at the 5'-position by the Hantzsch-type cyclization. This provides a versatile methodology for the construction of heterocycles from aliphatic fluoroalkoxy containing building blocks. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2012.01.005
• 作为产物：
  描述：

  四氟乙烯 、 2,2-二甲氧基-2-苯乙醇 在 氢化钾 作用下， 以 四氢呋喃 为溶剂， 20.0~35.0 ℃ 、101.33 kPa 条件下， 反应 8.0h， 生成 1-phenyl-1,1-dimethoxy-2-(1,1,2,2-tetrafluoroethoxy)ethane
  参考文献：
  名称：

  Efficient synthesis of 5′-fluoroalkoxythiazoles via α-bromo-α-fluoroalkoxyacetophenones Hantzsch type cyclization with thioureas or thioamides

  摘要：

  Novel alpha-fluoroalkoxyacetophenones were synthesized by addition of the readily available 2,2-dimethoxy-2-phenylethanol to fluoroolefins. alpha-Bromination yielded alpha-bromo-alpha-fluoroalkoxyacetophenones, which on treatment with thioureas or thioamides gave thiazoles with fluoroalkoxy groups at the 5'-position by the Hantzsch-type cyclization. This provides a versatile methodology for the construction of heterocycles from aliphatic fluoroalkoxy containing building blocks. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2012.01.005

文献信息

• Efficient synthesis of 5′-fluoroalkoxythiazoles via α-bromo-α-fluoroalkoxyacetophenones Hantzsch type cyclization with thioureas or thioamides
  作者：Taras M. Sokolenko、Yulia A. Davydova、Yurii L. Yagupolskii

  DOI：10.1016/j.jfluchem.2012.01.005

  日期：2012.4

  Novel alpha-fluoroalkoxyacetophenones were synthesized by addition of the readily available 2,2-dimethoxy-2-phenylethanol to fluoroolefins. alpha-Bromination yielded alpha-bromo-alpha-fluoroalkoxyacetophenones, which on treatment with thioureas or thioamides gave thiazoles with fluoroalkoxy groups at the 5'-position by the Hantzsch-type cyclization. This provides a versatile methodology for the construction of heterocycles from aliphatic fluoroalkoxy containing building blocks. (C) 2012 Elsevier B.V. All rights reserved.