申请人:Solvay Solexis S.p.A.
公开号:EP1864685A1
公开(公告)日:2007-12-12
The invention pertains to a process for the manufacture of a medical implant, said process comprising:
- reacting a mixture of non functional, monofunctional, and bifunctional perfluoropolyethers comprising hydroxyl terminal groups, wherein the average functionality is of at least 1.97 [mixture (M)] with suitable reactants for producing a thermoplastic elastomer;
- moulding the so-obtained thermoplastic elastomer for yielding at least a part of the medical implant.
It has been surprisingly found that by using a mixture of perfluoropolyethers having high functionality, it is advantageously possible to manufacture, by moulding thermoplastic elastomers therefrom, medical implants which exhibit improved biocompatibility and which are submitted to reduced chemicals extraction by biological fluids.
本发明涉及一种制造医疗植入物的工艺,所述工艺包括
- 将包含羟基末端基团的非官能团、单官能团和双官能团全氟聚醚混合物(其中平均官能度至少为 1.97 [混合物 (M)])与合适的反应物反应,生成热塑性弹性体;
- 将获得的热塑性弹性体模塑成型,生产出至少一部分医疗植入物。
令人惊奇的是,通过使用具有高功能性的全氟聚醚混合物,可以通过模塑热塑性弹性体的方法制造出具有更好生物相容性的医疗植入物,并减少生物液体对化学物质的萃取。