phthalanhydride | 184303-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异苯并呋喃
• 英文名称: phthalanhydride
• 英文别名: Tetrahydroisobenzofuran；1,3,3a,4-tetrahydro-2-benzofuran
• CAS: 184303-72-8
• 化学式: C₈H₁₀O
• 分子量: 122.167
• InChiKey: DCTDBKRLYIDBRN-UHFFFAOYSA-N

物化性质

• 沸点：
  208.7±29.0 °C(Predicted)
• 密度：
  1.04±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  aluminum acetate 、 尿素 、 phthalanhydride 在 hexaammonium heptamolybdate tetrahydrate sodium sulfate 作用下， 以 melt 为溶剂， 生成 铝酞菁
  参考文献：
  名称：

  Sulphonated phthalocyanines as effective oxidation photocatalysts for visible and UV light regions

  摘要：

  Attention was paid to the synthesis, chemical modification (sulphonation), characterisation and practical catalytic utilisation of metal free phthalocyanine and a series of phthalocyanines (PHCs) with Zn, Al, Si, Co, Ni, Cu and Ti central atoms. These organometallic compounds are referred to as highly active species due to their ability to produce singlet oxygen upon energy absorption. Photocatalytic efficiency of the prepared PHCs was tested in a model oxidation of 4-chlorophenol under illumination with visible and UV light in agreement with location of their distinctive absorption bands in both these regions. It was shown that different types of phthalocyanines revealed very different photocatalytic activities and only those with a long life-time of the excited triplet states (ZnPHC, SiPHC, AlPHC) effectively interacted with molecular oxygen to form the reactive singlet oxygen. The indispensable role of constant pH (similar to 10) was also clarified in separate experiments. Determined values of quantum yields for reactions carried out in the UV region were always higher than for reactions induced by the visible light. (C) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2007.03.024
• 作为产物：
  描述：

  (+/-)-8-oxatricyclo[4.3.0.0^1,4]non-2-ene 以 正戊烷 为溶剂， 反应 1.5h， 以85%的产率得到phthalanhydride
  参考文献：
  名称：

  Intramolecular Cycloadditions between Cyclobutadiene and Alkenes

  摘要：

  DOI：

  10.1021/ja9612559

文献信息

• [EN] FUSED HETEROCYCLIC COMPOUNDS AS S1P MODULATORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES CONDENSÉS À TITRE DE MODULATEURS DE S1P
  申请人：ABBVIE INC

  公开号：WO2017036978A1

  公开（公告）日：2017-03-09

  The invention relates to heterocyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.

  这项发明涉及杂环化合物作为S1P调节剂，包括这种化合物的药物组合物，以及在治疗、缓解或预防由S1P受体介导的疾病或紊乱中的用途。
• [EN] FUSED RING COMPOUNDS<br/>[FR] COMPOSÉS CYCLIQUES CONDENSÉS
  申请人：GENENTECH INC

  公开号：WO2020035031A1

  公开（公告）日：2020-02-20

  Provided are fused ring compounds of Formula (I), Formula (II), or Formula (III), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods treatment by their administration.

  提供的是公式(I)、公式(II)或公式(III)的融合环化合物，具体细节如下，这些化合物用于抑制Ras蛋白，以及包含这些化合物的组合物和通过其给药的治疗方法。
• TERTIARY AMINE COMPOUND OR IMINE COMPOUND-POLYMER CONJUGATE AND PRODUCTION METHOD THEREFOR
  申请人：Seikagaku Corporation

  公开号：US20200138964A1

  公开（公告）日：2020-05-07

  Provided is a compound obtained by conjugating a tertiary amine compound or imine compound, which is useful as a drug, with a polymer, in which a structure D + having a quaternary ammonium salt or iminium salt formed from a tertiary amine compound or imine compound D and a polymer residue Poly having a carboxy group are bonded to each other via a structure —C(R 1 )(R 2 )OC(O)ANHC(═O)—.

  提供的是一种化合物，通过将一种三级胺化合物或亚胺化合物与聚合物共轭，用作药物，其中具有由三级胺化合物或亚胺化合物D形成的季铵盐或亚胺盐的结构D + 和具有羧基的聚合物残基Poly通过结构—C(R 1 )(R 2 )OC(O)ANHC(═O)—相互键合。
• Organic photosensitive pigment
  申请人：Lin Liang-bih

  公开号：US20080076916A1

  公开（公告）日：2008-03-27

  Processes for making organic photosensitive pigments for charge generating layers of imaging members. The pigments may include titanyl phthalocyanine. The pigments may be synthesized through a partially electrochemical or purely electrochemical process. The pigments may be used in a charge generating layer of an imaging member having a substrate, the charge generating layer, and a charge transfer layer.

  用于成像元件的电荷生成层的有机感光颜料制备过程。这些颜料可能包括钛酸酯酞菁。这些颜料可以通过部分电化学或纯电化学过程合成。这些颜料可以用于成像元件的电荷生成层，该成像元件具有基板、电荷生成层和电荷转移层。
• FUSED (HETERO)CYCLIC COMPOUNDS AS S1P MODULATORS
  申请人：AbbVie Deutschland GmbH & Co. KG

  公开号：US20170174672A1

  公开（公告）日：2017-06-22

  The invention relates to (hetero)cyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.

  这项发明涉及(S1P)调节剂的(杂)环化合物，包括这种化合物的药物组合物，以及在通过S1P受体介导的疾病或紊乱的治疗、缓解或预防中的用途。