(carboxymethyl)dimethylisopropylammonium chloride | 143557-97-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (carboxymethyl)dimethylisopropylammonium chloride
• 英文别名: N-(Carboxymethyl)-N,N-dimethylpropan-2-aminium chloride；carboxymethyl-dimethyl-propan-2-ylazanium;chloride
• CAS: 143557-97-5
• 化学式: C₇H₁₆NO₂*Cl
• 分子量: 181.663
• InChiKey: OUHHZFSOSXAWRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.44
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-二甲基异丙胺 、 氯乙酰氯 在 吡啶 、 三氟乙酸 、 Wang resin 作用下， 生成 (carboxymethyl)dimethylisopropylammonium chloride
  参考文献：
  名称：

  Toxicity and osmoprotective activities of analogues of glycine betaine obtained by solid phase organic synthesis towards Sinorhizobium meliloti

  摘要：

  Seven analogues of the bacterial osmoprotectant glycine betaine (GB, trimethylammonioacetate), in which the methyl groups of the Me3N+ moiety are replaced by various substituents, were obtained by SPOS using Wang resin. Their biological activities (osmoprotection vs toxicity), appeared closely related to their uptake efficiency and their catabolism in the betaine-demethylating model bacterium Sinorhizobium meliloti. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00679-9

文献信息

• Toxicity and osmoprotective activities of analogues of glycine betaine obtained by solid phase organic synthesis towards Sinorhizobium meliloti
  作者：Anne Cosquer、Vianney Pichereau、Didier Le Mée、Myriam Le Roch、Jacques Renault、Bertrand Carboni、Philippe Uriac、Théophile Bernard

  DOI：10.1016/s0960-894x(98)00679-9

  日期：1999.1

  Seven analogues of the bacterial osmoprotectant glycine betaine (GB, trimethylammonioacetate), in which the methyl groups of the Me3N+ moiety are replaced by various substituents, were obtained by SPOS using Wang resin. Their biological activities (osmoprotection vs toxicity), appeared closely related to their uptake efficiency and their catabolism in the betaine-demethylating model bacterium Sinorhizobium meliloti. (C) 1998 Elsevier Science Ltd. All rights reserved.