羧基格列齐特 | 38173-52-3

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 羧基格列齐特
• 英文名称: Carboxy-Glyclazide
• 英文别名: Carboxy Gliclazide；4-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-ylcarbamoylsulfamoyl)benzoic acid
• CAS: 38173-52-3
• 化学式: C₁₅H₁₉N₃O₅S
• 分子量: 353.399
• InChiKey: DSNDPTBTZSQWJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Modulation of cellular stress using a B-cell oxidative and/or endoplasmic reticulum stress inhibitor and a targeting agent
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：US10695406B2

  公开（公告）日：2020-06-30

  Disclosed are compositions and methods for modulating oxidative and/or endoplasmic reticulum (OER) stress. More particularly, the present invention discloses compositions and methods that target OER stress inhibitors to pancreatic cells for treating diseases associated with oxidative and/or OER stress, including metabolic disorders such as diabetes.

  本发明公开了调节氧化和/或内质网（OER）应激的组合物和方法。更具体地说，本发明公开了将 OER 应激抑制剂靶向胰腺细胞的组合物和方法，用于治疗与氧化和/或 OER 应激相关的疾病，包括糖尿病等代谢性疾病。
• MODULATION OF CELLULAR STRESS
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：US20170143798A1

  公开（公告）日：2017-05-25

  Disclosed are compositions and methods for modulating oxidative and/or endoplasmic reticulum (OER) stress. More particularly, the present invention discloses compositions and methods that target OER stress inhibitors to pancreatic cells for treating diseases associated with oxidative and/or OER stress, including metabolic disorders such as diabetes.
• METHOD OF TREATING A METABOLIC DISORDER OF THE LIVER
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：US20200353048A1

  公开（公告）日：2020-11-12

  A method of treating a metabolic disorder of the liver includes administering a therapeutic agent. The therapeutic agent includes an IL-22 polypeptide and an antigen-binding molecule. The IL-22 polypeptide is fused or otherwise conjugated, directly or indirectly, to the antigen-binding molecule, and the antigen-binding molecule is an antibody or antigen-binding fragment that includes heavy and light chain CDR sequences.
• [EN] MODULATION OF CELLULAR STRESS<br/>[FR] MODULATION DE STRESS CELLULAIRE
  申请人：UNIV QUEENSLAND

  公开号：WO2015179918A1

  公开（公告）日：2015-12-03

  Disclosed are compositions and methods for modulating oxidative and/or endoplasmic reticulum (OER) stress. More particularly, the present invention discloses compositions and methods that target OER stress inhibitors to pancreatic cells for treating diseases associated with oxidative and/or OER stress, including metabolic disorders such as diabetes.