2-{[2-cyclohexyl-1-(phenylsulfonyl)ethyl]sulfanyl}pyridine | 103698-37-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-{[2-cyclohexyl-1-(phenylsulfonyl)ethyl]sulfanyl}pyridine
• 英文别名: 2-cyclohexyl-1-phenylsulphonyl-1-(pyridine-2-thiyl)ethane；2-cyclohexyl-1-(2-pyridylsulfanyl)ethyl phenyl sulfone；Pyridine, 2-[[2-cyclohexyl-1-(phenylsulfonyl)ethyl]thio]-；2-[1-(benzenesulfonyl)-2-cyclohexylethyl]sulfanylpyridine
• CAS: 103698-37-9
• 化学式: C₁₉H₂₃NO₂S₂
• 分子量: 361.529
• InChiKey: DIHGEEWLXDFEFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  80.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-{[2-cyclohexyl-1-(phenylsulfonyl)ethyl]sulfanyl}pyridine 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Barton, Derek H. R.; Chern, Ching-Yuh; Jaszberenyi, Joseph Cs., Australian Journal of Chemistry, 1995, vol. 48, # 2, p. 407 - 426

  摘要：

  DOI：
• 作为产物：
  描述：

  苯基乙烯基砜 、 Cyclohexanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 2-{[2-cyclohexyl-1-(phenylsulfonyl)ethyl]sulfanyl}pyridine
  参考文献：
  名称：

  Decarboxylative radical addition to vinylsulphones and vinylphosphonium bromide: Some further novel transformations of geminal (pyridine-2-thiyl) phenylsulphones.

  摘要：

  Irradiation of O-acyl derivatives 1 of N-hydroxy- 2-thiopyridone with visible light in the presence of phenyl vinyl sulphone or vinyl triphenylphosphonium bromide leads to the corresponding adducts 8 and 9 which can undergo a wide variety of further transformations.

  DOI：

  10.1016/s0040-4020(01)96163-0

文献信息

• Conversion of Hydroxyl Groups in Alcohols to Other Functional Groups with<i>N</i>-Hydroxy-2-thiopyridone, and Its Application to Dialkylamines and Thiols
  作者：Hideo Togo、Misa Fujii、Masataka Yokoyama

  DOI：10.1246/bcsj.64.57

  日期：1991.1

  The radical decarboxylation reaction of N-alkoxyoxalyloxy-2-thiopyridone which was prepared by the reaction of alcohol, oxalyl chloride, and N-hydroxy-2-thiopyridone was studied both in the absence and presence of olefinic compounds. The same reactions with olefinic and acetylenic alcohols gave the corresponding lactone derivatives. On the other hand the unsymmetrical alkyl 2-pyridyl disulfides were obtained by the same reaction with aliphatic thiols.

  对由醇、草酰氯和N-羟基-2-噻吩酮反应制备的N-烷氧基草酰氧基-2-噻吩酮的还原脱羧反应进行了研究，无论是在没有还是有烯烃化合物存在的情况下。同样，与烯醇和炔醇的反应得到了相应的内酯衍生物。另一方面，通过与脂肪族硫醇的相同反应得到了不对称的烷基-2-吡啶基二硫化物。
• <i>B</i>-Alkylcatecholboranes as a Source of Radicals for Efficient Conjugate Additions­ and Allylations
  作者：Philippe Renaud、Arnaud-Pierre Schaffner、Barbara Becattini、Cyril Ollivier、Valéry Weber

  DOI：10.1055/s-2003-42430

  日期：——

  B-Alkylcatecholboranes, easily prepared in situ by hydroboration of alkenes, are powerful radical precursors that can be used for carbon-carbon bond formation. Typical procedures for (a) conjugate addition to enones, (b) conjugate addition to activated alkenes such as vinyl sulfones, and (c) direct allylation are described. Experimentally, these three one-pot reactions are easy to perform. No slow

  B-烷基儿茶酚硼烷很容易通过烯烃的硼氢化原位制备，是强大的自由基前体，可用于碳-碳键的形成。描述了 (a) 与烯酮共轭加成、(b) 与乙烯基砜等活化烯烃共轭加成和 (c) 直接烯丙基化的典型程序。实验上，这三个一锅法反应很容易进行。不需要缓慢添加试剂，这是分子间自由基添加中经常遇到的过程。
• Radical addition to vinyl sulphones and vinyl phosphonium salts
  作者：Derek H.R. Barton、Hideo Togo、Samir Z. Zard

  DOI：10.1016/s0040-4039(01)84596-2

  日期：——

  Alkyl radicals, derived from decarboxylation of carboxylic acids, add readily to phenyl vinyl sulphone and vinyl phosphonium bromide. The adducts may be further converted into a variety of useful synthetic intermediates.

  衍生自羧酸脱羧的烷基很容易加到苯基乙烯基砜和乙烯基溴化phospho中。加合物可以进一步转化成各种有用的合成中间体。
• Ishigami, Sachiko; Togo, Hideo; Yokoyama, Masataka, Journal of the Chemical Society. Perkin transactions I, 1994, # 17, p. 2407 - 2412
  作者：Ishigami, Sachiko、Togo, Hideo、Yokoyama, Masataka

  DOI：——

  日期：——
• A Convenient and General Tin-Free Procedure for Radical Conjugate Addition
  作者：Cyril Ollivier、Philippe Renaud

  DOI：10.1002/(sici)1521-3773(20000303)39:5<925::aid-anie925>3.0.co;2-m

  日期：2000.3.3