dimethylacetal du diazoacetaldehyde | 57331-59-6

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 炔丙基型1，3-偶极有机化合物
• 英文名称: dimethylacetal du diazoacetaldehyde
• 英文别名: Diazoacetaldehyde dimethylacetal；dimethylacetal du diazoaldehyde；2,2-dimethoxydiazoethane；diazoacetal；2-diazo-1,1-dimethoxy-ethane；2,2-dimethoxy-1-diazoethane；2-diazo-1,1-dimethoxyethane
• CAS: 57331-59-6
• 化学式: C₄H₈N₂O₂
• 分子量: 116.12
• InChiKey: TZVOTJQVMPNYCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  20.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dimethylacetal du diazoacetaldehyde 在 重水 、 potassium carbonate 作用下， 以 乙醚 为溶剂， 反应 6.0h， 以200 mg的产率得到
  参考文献：
  名称：

  Abdallah, Hassan; Gree, Rene; Carrie, Robert, Canadian Journal of Chemistry, 1983, vol. 61, p. 217 - 223

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(2,2-二甲氧基乙基)-1-亚硝基脲 在 sodium hydroxide 作用下， 以 乙醚 为溶剂， 生成 dimethylacetal du diazoacetaldehyde
  参考文献：
  名称：

  Abdallah, Hassan; Gree, Rene; Carrie, Robert, Canadian Journal of Chemistry, 1983, vol. 61, p. 217 - 223

  摘要：

  DOI：

文献信息

• 1,3-Dipolar cycloaddition in the synthesis of pyrazolyl-substituted nitronyl nitroxides
  作者：E. V. Tretyakov、S. E. Tolstikov、G. V. Romanenko、Yu. G. Shvedenkov、R. Z. Sagdeev、V. I. Ovcharenko

  DOI：10.1007/s11172-006-0093-6

  日期：2005.9

  A new approach to the synthesis of polyfunctional pyrazolyl-substituted nitronyl nitroxides was developed based on the presynthesized pyrazole derivatives prepared by 1,3-dipolar cycloaddition. The structures of the resulting mono-and biradicals were confirmed by X-ray diffraction.

  基于通过 1,3-偶极环加成制备的预合成吡唑衍生物，开发了一种合成多功能吡唑基取代的硝酰基氮氧化物的新方法。通过 X 射线衍射证实了所得单自由基和双自由基的结构。
• Synthese et reactivite d'oxycyclopropanes electrophiles
  作者：Hassan Abdallah、René Grée、Robert Carrié

  DOI：10.1016/s0040-4020(01)97205-9

  日期：1985.1

  “Electrophilic oxycyclopropanes” 4 to 6 have been prepared starting from olefins 7. Ring opening of these cyclopropanes occurs under very smooth conditions (DMSO, room temperature). A push-pull type system is then also a powerful driving force with regard to the C-C bond cleavage in cyclopropanes.

  从烯烃7开始制备“亲电性氧环丙烷” 4至6。这些环丙烷的开环发生在非常平稳的条件下（DMSO，室温）。对于环丙烷中的CC键裂解，推挽式系统也是一个强大的驱动力。
• [EN] 5-SUBSTITUTED 2H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE NICOTINIC ACID RECEPTOR RUP25 FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES<br/>[FR] DERIVES D'ACIDE 2H-PYRAZOL-3- CARBOXYLIQUE SUBSTITUES EN 5 UTILISES COMME AGONISTES DU RECEPTEUR DE L'ACIDE NICOTINIQUE RUP25 POUR LE TRAITEMENT DES DYSLIPIDEMIES ET DES PATHOLOGIES APPARENTEES
  申请人：ARENA PHARM INC

  公开号：WO2005011677A1

  公开（公告）日：2005-02-10

  The present invention relates to certain pyrazole carboxylic acid and ester derivatives, and pharmaceutically acceptable salts thereof, which exhibit useful pharmaceutical properties, for example as agonists for the RUP25 receptor. (I) Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.the substituents are defined in claim 1.

  本发明涉及某些吡唑羧酸和酯衍生物及其药学上可接受的盐，这些衍生物具有有用的药理特性，例如作为RUP25受体的激动剂。本发明还提供了含有该发明化合物的药物组合物，并且提供了使用该发明化合物和组合物在预防或治疗代谢相关疾病，包括血脂异常、动脉粥样硬化、冠心病、胰岛素抵抗、2型糖尿病、X综合症等方面的方法。此外，本发明还提供了与其他活性剂（例如属于α-葡萄糖苷酶抑制剂、醛还原酶抑制剂、双胍类药物、HMG-CoA还原酶抑制剂、角鲨烷合成抑制剂、纤维酸类药物、LDL降解增强剂、血管紧张素转换酶（ACE）抑制剂、胰岛素分泌增强剂等类别的）联合使用的本发明化合物的用途。取代基定义详见权利要求书第1项。
• 5-Substituted 2h-pyrazole-3-carboxylic acid derivatives as agonists for the acid receptor rup25 for the treatment of dyslipidemia and related diseases
  申请人：Semple Graeme

  公开号：US20070032537A1

  公开（公告）日：2007-02-08

  The present invention relates to certain pyrazole carboxylic acid and ester derivatives, and pharmaceutically acceptable salts thereof, which exhibit useful pharmaceutical properties, for example as agonists for the RUP25 receptor. (I) Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like the substituents are defined in claim 1.

  本发明涉及某些吡唑羧酸和酯衍生物及其药学上可接受的盐，其表现出有用的药理特性，例如作为RUP25受体的激动剂。此外，本发明还提供了含有本发明化合物的药物组合物，以及使用本发明化合物和组合物在代谢相关疾病的预防或治疗中的方法，包括血脂异常、动脉粥样硬化、冠心病、胰岛素抵抗、2型糖尿病、X综合症等。此外，本发明还提供了将本发明化合物与其他活性剂（如属于α-葡萄糖苷酶抑制剂、醛还原酶抑制剂、双胍类、HMG-CoA还原酶抑制剂、角鲨烷合成抑制剂、纤维酸类、LDL降解增强剂、血管紧张素转化酶（ACE）抑制剂、胰岛素分泌增强剂等类别的）联合使用的方法。其中，取代基在权利要求1中定义。
• Perrocheau, J.; Carrie, R., Bulletin des Societes Chimiques Belges, 1993, vol. 102, # 11/12, p. 749 - 760
  作者：Perrocheau, J.、Carrie, R.

  DOI：——

  日期：——