2-(2-fluorophenoxy)propanoyl chloride | 904702-97-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(2-fluorophenoxy)propanoyl chloride
• CAS: 904702-97-2
• 化学式: C₉H₈ClFO₂
• 分子量: 202.613
• InChiKey: HLFFXTZPFVSMKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.36
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-(2-fluorophenoxy)propanoyl chloride 、 1-羟基-1-(4-甲基苯基)甲基膦酸二甲酯 在 三乙胺 作用下， 生成
  参考文献：
  名称：

  α-[2-(氟代苯氧基)丙酰氧基]烷基膦酸酯的合成及除草活性

  摘要：

  合成了八种新型氟取代膦酸酯衍生物，初步生物测定表明这些化合物具有除草活性。

  DOI：

  10.1080/10426500701807566
• 作为产物：
  描述：

  2-(2-氟-苯氧基)-丙酸 在 氯化亚砜 作用下， 生成 2-(2-fluorophenoxy)propanoyl chloride
  参考文献：
  名称：

  α-[2-(氟代苯氧基)丙酰氧基]烷基膦酸酯的合成及除草活性

  摘要：

  合成了八种新型氟取代膦酸酯衍生物，初步生物测定表明这些化合物具有除草活性。

  DOI：

  10.1080/10426500701807566

文献信息

• Design, synthesis and structure–activity relationship studies of novel phenoxyacetamide-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes
  作者：Zheng Li、Xuekun Wang、Xue Xu、Jianyong Yang、Qianqian Qiu、Hao Qiang、Wenlong Huang、Hai Qian

  DOI：10.1016/j.bmc.2015.09.010

  日期：2015.10

  The free fatty acid receptor 1 (FFA1) has attracted extensive attention as a novel antidiabetic target in the last decade. Several FFA1 agonists reported in the literature have been suffered from relatively high molecular weight and lipophilicity. We have previously reported the FFA1 agonist 1. Based on the common amide structural characteristic of SAR1 and NIH screened compound, we here describe the continued structure-activity exploration to decrease the molecular weight and lipophilicity of the compound 1 series by converting various amide linkers. All of these efforts lead to the discovery of the preferable lead compound 18, a compound with considerable agonistic activity, high LE and LLE values, lower lipophilicity than previously reported agonists, and appreciable efficacy on glucose tolerance in both normal and type 2 diabetic mice. (c) 2015 Published by Elsevier Ltd.
• Synthesis and Herbicidal Activity of α-[2-(Fluoro-Substituted Phenoxy)Propionyloxy] Alkyl Phosphonates
  作者：Yan-Jun Li、Hong-Wu He

  DOI：10.1080/10426500701807566

  日期：2008.1.14

  Eight of novel fluoro-substituted phosphonate derivatives were synthesized and the preliminary bioassay indicated that these compounds exhibited herbicidal activities.

  合成了八种新型氟取代膦酸酯衍生物，初步生物测定表明这些化合物具有除草活性。