1',4'-bis(4-carboxy-2-methoxyphenoxy)butane | 3030-31-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1',4'-bis(4-carboxy-2-methoxyphenoxy)butane
• 英文别名: 3,3'-dimethoxy-4,4'-butanediyldioxy-di-benzoic acid；3,3'-Dimethoxy-4,4'-butandiyldioxy-di-benzoesaeure；1,4-Bis-(4-carboxy-2-methoxy-phenoxy)-butan；4-[4-(4-Carboxy-2-methoxyphenoxy)butoxy]-3-methoxybenzoic acid
• CAS: 3030-31-7
• 化学式: C₂₀H₂₂O₈
• 分子量: 390.39
• InChiKey: XTRCWKFJYCOFNN-UHFFFAOYSA-N

物化性质

• 熔点：
  233-241 °C
• 沸点：
  594.9±50.0 °C(Predicted)
• 密度：
  1.282±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1',4'-bis(4-carboxy-2-methoxyphenoxy)butane 在 sodium hydroxide 、 硝酸 、 四氯化锡 、 potassium carbonate 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 为溶剂， 反应 6.75h， 生成 1',4'-bis(4-carboxy-2-methoxy-5-nitrophenoxy)butane
  参考文献：
  名称：

  Effect of linker length on DNA-binding affinity, cross-linking efficiency and cytotoxicity of C8-linked pyrrolobenzodiazepine dimers

  摘要：

  报道了一种高效的C8连接吡咯并苯并二氮杂䓬二聚体的同系物合成方法；连接链中具有奇数个亚甲基（n=3或5）的化合物对DNA具有更高的亲和力，交叉连接效率增强，并且相比于n=4或6的化合物更具细胞毒性。

  DOI：

  10.1039/c39920001518
• 作为产物：
  描述：

  1,4-二溴丁烷 生成 1',4'-bis(4-carboxy-2-methoxyphenoxy)butane
  参考文献：
  名称：

  Takamuku; Hachihama, Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1958, vol. 61, p. 1097

  摘要：

  DOI：

文献信息

• Linear polyesters derived from vanillic acid
  作者：Louis H. Bock、James K. Anderson

  DOI：10.1002/pol.1955.120178607

  日期：1955.8

  Vanillic acid, which is potentially available from lignin, was converted to dibasic acids by etherifying the phenolic hydroxyl group with alkylene dihalides. The dibasic acids were esterified with ethylene glycol and condensed to linear polyesters. The polyesters were converted to fibers by melt spinning. The fibers could be stretched, preferably in a warm water bath, to give fibers with good tenacity

  香草酸可能从木质素中获得，通过用亚烷基二卤化物将酚羟基醚化，将其转化为二元酸。二元酸用乙二醇酯化并缩合成线性聚酯。通过熔融纺丝将聚酯转化为纤维。可以拉伸纤维，优选在温水浴中拉伸，以得到具有良好韧度和增加的结晶度的纤维，如双折射测量所示。由乙烯二香草酸获得的聚酯在 210°C 下熔化。但在 80°C 时软化并收缩。
• Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-<i>c</i>][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents
  作者：David E. Thurston、D. Subhas Bose、Andrew S. Thompson、Philip W. Howard、Alberto Leoni、Stephen J. Croker、Terrence C. Jenkins、Stephen Neidle、John A. Hartley、Laurence H. Hurley

  DOI：10.1021/jo951631s

  日期：1996.11.15

  An efficient convergent synthesis of a homologous series of C8-linked pyrrolobenzodiazepine dimers with remarkable DNA interstrand cross-linking activity and potent in vitro cytotoxicity is reported. The "amino thioacetal" cyclization procedure was used to produce the electrophilic DNA-interactive N10-C11 imine moiety during the final synthetic step. In order to construct the key A-ring fragments (9a-d)

  据报道，具有一系列显着的DNA链交联活性和强大的体外细胞毒性的C8连接的吡咯并苯并二氮杂二聚体同源系列的高效收敛合成。在最后的合成步骤中，使用“氨基硫缩醛”环化程序来生产亲电的DNA相互作用的N10-C11亚胺部分。为了构建关键的A环片段（9a-d），已开发了一种通用的收敛方法，以将两个单位的香草酸与不同长度的α，ω-二卤代烷烃连接起来，以提供所需的双（4-羧基-2） -甲氧基苯氧基）烷烃，同时避免形成单烷基化和双烷基化产物的混合物。
• Polyphenylene ether resin composition
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP0148774A2

  公开（公告）日：1985-07-17

  A polyphenylene ether resin composition containing (A) a polyphenylene ether resin, (B) an aromatic polyester resin, and (C) a phenoxy resin. The resin composition may further contain (D) an unsaturated carboxylic acid and/or (E) a vinyl copolymer derived from a styrene compound and an alpha, beta-unsaturated dicarboxylic acid anhydride as comonomer components. The resin composition has excellent mechanical strength, solvent resistance, oil resistance and moldability.

  一种聚苯醚树脂组合物，含有 (A) 聚苯醚树脂、(B) 芳香族聚酯树脂和 (C) 苯氧基树脂。 该树脂组合物还可进一步含有 (D) 不饱和羧酸和/或 (E) 由苯乙烯化合物和α、β-不饱和二羧酸酐衍生的乙烯基共聚物作为共聚单体组分。 该树脂组合物具有优异的机械强度、耐溶剂性、耐油性和成型性。
• Dibasic ether acid derivatives of vanillic acid
  申请人：RAYONIER INC

  公开号：US02630454A1

  公开（公告）日：1953-03-03
• ULTRAVIOLET-RAY ABSORBING POLYMER, FORMATION RESIN COMPOSITION, AND FORMED BODY
  申请人：TOYO INK SC HOLDINGS CO., LTD.

  公开号：US20210380743A1

  公开（公告）日：2021-12-09

  An ultraviolet-ray absorbing polymer containing a monomer unit represented by general formula (12) below and a monomer unit derived from a monomer represented by general formula (1) below. In general formula (12), R 6 represents any one selected from a group consisting of a hydrogen atom and a methyl group, U represents a hydrocarbon group, and the hydrocarbon group includes a skeleton absorbing ultraviolet rays and optionally contains a heteroatom. In general formula (1), R 16 represents any one selected from a group consisting of a hydrogen atom and a methyl group, and Z represents any one selected from a group consisting of a chain hydrocarbon group having 10 or more carbon atoms and a polycyclic hydrocarbon group having 10 or more carbon atoms.