myriocin | 35891-70-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: myriocin
• 英文别名: (E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-icos-6-enoic acid；(E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid
• CAS: 35891-70-4；128440-98-2；139492-74-3
• 化学式: C₂₁H₃₉NO₆
• 分子量: 401.544
• InChiKey: ZZIKIHCNFWXKDY-FMIVXFBMSA-N

物化性质

• 熔点：
  170-172℃
• 沸点：
  636.7±55.0 °C(Predicted)
• 密度：
  1.123±0.06 g/cm3(Predicted)
• 溶解度：
  甲醇：2 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  28
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  141
• 氢给体数：
  5
• 氢受体数：
  7

安全信息

• 危险品标志：
  Xn,Xi
• 危险类别码：
  R22
• 危险品运输编号：
  UN 2811 6.1/PG 3

制备方法与用途

多球壳菌素是什么 多球壳菌素是一种真菌代谢产物，具有抑菌、免疫调节和抗动脉粥样硬化等药理作用。在金蝉花中，多球壳菌素主要存在于菌丝体部分。从金蝉花中提取的多球壳菌素对小鼠由高糖诱导的细胞外基质合成及肾小球系膜细胞肥大有抑制作用，并且能抑制大鼠的肾小球系膜细胞增生。因此，多球壳菌素在动物实验模型中表现出较明显的肾功能保护作用。

生物活性 Myriocin 是一种从 Myriococcum albomyces、Isaria sinclairi 和 Mycelia sterilia 中分离出的真菌代谢产物，是一种有效的丝氨酸-棕榈酰转移酶 (serine-palmitoyl-transferase) 抑制剂，是鞘脂从头合成的关键。Myriocin 强烈抑制亚基因组 HCV-1b 复制子和基因型 2a 感染性 HCV 的 JFH-1 株的复制，其抑制 HCV 感染的 IC50 值为 3.5 μg/mL。

靶点 丝氨酸-棕榈酰转移酶 (SPT)

文献信息

• Small molecule immunopotentiators and assays for their detection
  申请人：Valiante Nicholas

  公开号：US20110104186A1

  公开（公告）日：2011-05-05

  The invention provides immunostimulatory compositions comprising a small molecule immuno-potentiator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma. In a further aspect, the invention relates generally to methods of screening for small molecule immuno-modulatory compositions.
• METHODS OF TREATMENT, DIAGNOSIS AND MONITORING FOR METHAMPHETAMINE TOXICITY WHICH TARGET CERAMIDE METABOLIC PATHWAYS AND CELLULAR SENESCENCE
  申请人：The Regents of the University of California

  公开号：US20150148387A1

  公开（公告）日：2015-05-28

  Methamphetamine is a highly addictive psychostimulant that causes profound damage to the brain and other body organs. Post mortem studies of human tissues have linked the use of this drug to diseases associated with aging, such as coronary atherosclerosis, but the molecular mechanism underlying these findings remains unknown. We report now that methamphetamine accelerates cellular senescence in vitro and activates transcription of genes involved in cell-cycle control and inflammation in vivo by stimulating production of the sphingolipid messenger ceramide. This pathogenic cascade is triggered by reactive oxygen species, generated through methamphetamine metabolism via cytochrome P 450 -2D6, which recruit nuclear factor (NF)-KB to induce expression of enzymes in the de novo pathway of ceramide biosynthesis. Inhibitors of ceramide formation prevent methamphetamine-induced senescence and attenuate systemic inflammation and health deterioration in rats self-administering the drug. The results support therapeutic approaches to reduce the adverse consequences of methamphetamine abuse and improve effectiveness of treatments.
• US3928572A
  申请人：——

  公开号：US3928572A

  公开（公告）日：1975-12-23
• US9925160B1
  申请人：——

  公开号：US9925160B1

  公开（公告）日：2018-03-27
• [EN] METHODS OF TREATMENT, DIAGNOSIS AND MONITORING FOR METHAMPHETAMINE TOXICITY WHICH TARGET CERAMIDE METABOLIC PATHWAYS AND CELLULAR SENESCENCE<br/>[FR] PROCÉDÉS DE TRAITEMENT, DE DIAGNOSTIC ET DE SURVEILLANCE DE LA TOXICITÉ DE LA MÉTHAMPHÉTAMINE QUI CIBLENT DES VOIES MÉTABOLIQUES DES CÉRAMIDES ET LA SÉNESCENCE CELLULAIRE
  申请人：UNIV CALIFORNIA

  公开号：WO2013149250A1

  公开（公告）日：2013-10-03

  Methamphetamine is a highly addictive psychostimulant that causes profound damage to the brain and other body organs. Post mortem studies of human tissues have linked the use of this drug to diseases associated with aging, such as coronary atherosclerosis, but the molecular mechanism underlying these findings remains unknown. We report now that methamphetamine accelerates cellular senescence in vitro and activates transcription of genes involved in cell-cycle control and inflammation in vivo by stimulating production of the sphingolipid messenger ceramide. This pathogenic cascade is triggered by reactive oxygen species, generated through methamphetamine metabolism via cytochrome Pas0-2D6, which recruit nuclear factor (NF)-KB to induce expression of enzymes in the de novo pathway of ceramide biosynthesis. Inhibitors of ceramide formation prevent methamphetamine-induced senescence and attenuate systemic inflammation and health deterioration in rats self- administering the drug. The results support therapeutic approaches to reduce the adverse consequences of methamphetamine abuse and improve effectiveness of treatments.