N-formyl-1,2,3,4-tetrahydro-4-oxo-1-naphthylamine | 62089-80-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: N-formyl-1,2,3,4-tetrahydro-4-oxo-1-naphthylamine
• 英文别名: (-)-N-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)formamide；N-(4-Oxo-1,2,3,4-tetrahydronaphthalen-1-yl)formamide；N-(4-oxo-2,3-dihydro-1H-naphthalen-1-yl)formamide
• CAS: 62089-80-9
• 化学式: C₁₁H₁₁NO₂
• 分子量: 189.214
• InChiKey: CPJFLSPXSVXODQ-UHFFFAOYSA-N

物化性质

• 沸点：
  406.6±35.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-formyl-1,2,3,4-tetrahydro-4-oxo-1-naphthylamine 在 盐酸 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 生成 1-Methyl-3-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)-urea
  参考文献：
  名称：

  Synthesis of 1,2,3,4-tetrahydro-4-oxo-[or oxy-]-1-naphthylureas as novel

  摘要：

  这项发明涉及新型1,2,3,4-四氢-4-氧基-[-氧基-]-1-萘基脲化合物及其衍生物。该发明还涉及所述化合物的制备方法。此外，该发明还涉及将所述四氢-4-氧基-[氧基-]-1-萘基脲化合物用作动物生长调节剂的方法。

  公开号：

  US04089976A1
• 作为产物：
  描述：

  cerium(IV) sulphate 、 N-(1,2,3,4-tetrahydronaphthalen-1-yl)formamide 、 重铬酸 在 cerium (IV) ammonium nitrate 作用下， 以 乙酸酐 为溶剂， 生成 N-formyl-1,2,3,4-tetrahydro-4-oxo-1-naphthylamine
  参考文献：
  名称：

  Novel 1,2,3,4-tetrahydro-4-oxo-(oxy)-1-naphthylamines and method of

  摘要：

  本公开说明了1,2,3,4-四氢-4-氧代-（氧基）-1-萘胺及其新型衍生物的方法，以及制备这些化合物的方法。这些新型化合物是制备1,2,3,4-四氢-4-氧代（氧基）-1-萘基脲和硫脲化合物及其某些衍生物的有用和宝贵的中间体，这些化合物是动物生长促进剂。

  公开号：

  US04049717A1

文献信息

• 1,2,3,4-Tetrahydropyrazin-2-yl acetamides and methods of use
  申请人：Askew C. Benny

  公开号：US20060025400A1

  公开（公告）日：2006-02-02

  Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于治疗疼痛和疾病，如炎症介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药学上可接受的衍生物，药物组合物以及用于预防和治疗涉及疼痛、炎症等疾病和其他不适或情况的方法。该发明还涉及制备此类化合物的方法，以及在此类过程中有用的中间体。
• 1-Benzoyl-3-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)-urea, a novel and
  申请人：American Cyanamid Company

  公开号：US04051183A1

  公开（公告）日：1977-09-27

  This invention relates to 1-benzoyl (and 1-substituted benzoyl)-3-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)ureas, novel and useful intermediates for the preparation of 1,2,3,4-tetrahydro-4-oxo-1-naphthylurea and certain derivatives thereof. The above tetrahydro-4-oxo-1-naphthyl-urea and certain derivatives thereof are animal growth promoting agents. This invention further relates to methods of preparation of said 1-benzoyl (and 1-substituted benzoyl) 3-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)ureas.

  本发明涉及1-苯甲酰（和1-取代苯甲酰）-3-（1,2,3,4-四氢-4-氧-1-萘基）脲，是制备1,2,3,4-四氢-4-氧-1-萘基脲及其某些衍生物的新型有用中间体。上述四氢-4-氧-1-萘基脲及其某些衍生物是动物生长促进剂。本发明还涉及制备所述1-苯甲酰（和1-取代苯甲酰）-3-（1,2,3,4-四氢-4-氧-1-萘基）脲的方法。
• 1,2,3,4-Tetrahydro-4-oxo-1-naphthylisocyanate
  申请人：American Cyanamid Company

  公开号：US03993677A1

  公开（公告）日：1976-11-23

  This invention relates to 1,2,3,4-tetrahydro-4-oxo-1-naphthylisocyanate and- isothiocyanate and to methods of preparation of said compounds. The compounds of the present invention are useful as intermediates for the preparation of 1,2,3,4-tetrahydro-4-oxo(oxy)-1-naphthylurea and- thiourea compounds and certain derivatives thereof. The naphthylurea and thiourea compounds are animal growth regulators and herbicides.

  本发明涉及1,2,3,4-四氢-4-氧基-1-萘基异氰酸酯和异硫氰酸酯及其制备方法。本发明的化合物可用作1,2,3,4-四氢-4-氧基（氧）-1-萘基脲和硫脲化合物及其某些衍生物的中间体。萘基脲和硫脲化合物是动物生长调节剂和除草剂。
• 1,3-Dithiolane compounds and method of preparation thereof
  申请人：American Cyanamid Company

  公开号：US04075228A1

  公开（公告）日：1978-02-21

  There are provided substituted 1,3-dithiolane compounds and a method for preparing the same. Said 1,3-dithiolane compounds are useful intermediates in the preparation of tetrahydro-7-oxobenzo[b]thien-4-ylureas and tetrahydro-4-oxo-1-naphthylureas which are known animal growth-promoting agents, which thiolanes are represented by the formula: ##STR1## wherein R.sub.1 is a member selected from the group consisting of 2-thienyl and phenyl; R.sub.2 is a member selected from the group consisting of ##STR2## wherein X is chlorine or bromine; R.sub.3 and R.sub.4 are each members selected from the group consisting of hydrogen and methyl; and when R.sub.1 and R.sub.2 are taken together with the carbon atom to which they are attached they represent a bicyclic moiety selected from the group consisting of ##STR3## wherein the carbon atom of said bicyclic moiety marked with an asterisk is also part of the 1,3-dithiolane ring; U is a moiety selected from the group consisting of ##STR4## and when U is ##STR5## said compounds are the racemic mixtures and the optical isomers thereof.

  提供了替代的1,3-二硫杂环化合物及其制备方法。所述1,3-二硫杂环化合物是制备已知的动物生长促进剂四氢-7-氧代苯并[b]噻唑-4-基脲和四氢-4-氧代-1-萘基脲的有用中间体，该硫杂环的化学式为：##STR1## 其中R.sub.1是从2-噻吩基和苯基中选择的成员；R.sub.2是从##STR2## 中选择的成员，其中X是氯或溴；R.sub.3和R.sub.4是从氢和甲基中选择的成员；当R.sub.1和R.sub.2与它们连接的碳原子一起被选为从##STR3## 中选择的双环基团时，它们代表一个双环基团，其中带有星号的双环基团的碳原子也是1,3-二硫杂环的一部分；U是从##STR4## 中选择的基团；当U是##STR5## 时，所述化合物是外消旋混合物及其光学异构体。
• Tetrahydro-4-imino-1-naphthylureas
  申请人：American Cyanamid Company

  公开号：US04041070A1

  公开（公告）日：1977-08-09

  There are provided certain substituted-1,2,3,4-tetrahydro-4-imino-1-naphthylureas, methods of preparation thereof, and methods of use of said naphthylureas for enhancing feed efficiency and for promoting the growth rate of veterinary homothermic animals.

  提供了某些替代的1,2,3,4-四氢-4-亚胺-1-萘酰脲，其制备方法和用于增强兽医同温动物的饲料效率和促进生长速度的萘酰脲的使用方法。