isopentyl(phenyl)sulfane | 13910-11-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: isopentyl(phenyl)sulfane
• 英文别名: 3-Methylbutylsulfanylbenzene
• CAS: 13910-11-7
• 化学式: C₁₁H₁₆S
• 分子量: 180.314
• InChiKey: DTADFKNTXRGGOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  isopentyl(phenyl)sulfane 在 三氯化铝 作用下， 以 二硫化碳 为溶剂， 生成 2-{3-[4-(3-methyl-butylsulfanyl)-phenyl]-3-oxo-propyl}-1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one
  参考文献：
  名称：

  Hannig,E., Pharmazie, 1962, vol. 17, p. 677 - 679

  摘要：

  DOI：
• 作为产物：
  描述：

  [(3-甲基丁-2-烯-1-基)硫代]苯 在 (1+)*CH3COO(1-) 乙醇 、 氢气 、 sodium 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 25.0~80.0 ℃ 、405.3 kPa 条件下， 反应 2.0h， 生成 isopentyl(phenyl)sulfane
  参考文献：
  名称：

  Low Pressure Hydrogenation of Unsaturated Sulphides with Homogeneous and Heterogeneous Ruthenium Catalysts

  摘要：

  Ru2O . nH(2)O and [Ru3O(AcO)(6)(H2O)(3)](AcO-)-Ac-+ were examined for catalytic activity in the hydrogenation of a series of unsaturated sulphides under heterogeneous and homogeneous conditions, respectively. By the appropriate combination of these two methodologies, a number of saturated sulphides could be synthesized in satisfactory to good yields, thus minimizing side reactions.

  DOI：

  10.1080/00397919608003694

文献信息

• An Iodine-Mediated Hofmann-Löffler-Freytag Reaction of Sulfoximines Leading to Dihydroisothiazole Oxides
  作者：Duo Zhang、Han Wang、Hanchao Cheng、José G. Hernández、Carsten Bolm

  DOI：10.1002/adsc.201701178

  日期：2017.12.19

  A Hofmann‐Löffler‐Freytag type cyclization reaction of S‐aryl‐S‐phenylpropyl sulfoximines (and related derivatives) was developed. Using molecular iodine as the initiator under visible light a series of five‐membered cyclic products was obtained in moderate to high yields. The approach represents a new strategy for the synthesis of dihydroisothiazole oxides and benzo[d]isothiazoles‐1‐oxides.

  的霍夫曼-洛夫勒-Freytag型环化反应小号-芳基-小号苯基丙基的亚磺酰亚胺（和相关的衍生物）的开发。使用分子碘作为引发剂，在可见光下可以中等至高收率获得一系列五元环状产物。该方法代表了合成二氢异噻唑氧化物和苯并[ d ]异噻唑-1-氧化物的新策略。
• Synthesis of carboxylic acids and their methyl esters from alkyl phenyl sulphides
  作者：Carlos C. Fortes、Helena C. Fortes、Dionéia C. R. G. Gonçalves

  DOI：10.1039/c39820000857

  日期：——

  Alkyl phenyl sulphides are converted with sulphuryl chloride and pyridine under controlled temperatures into 1,1-dichloroalkyl phenyl sulphides or 1-chloroalk-1-enyl sulphides; treatment of these intermediates with methanol-water (1%v/v) and mercury(II) acetate–formic acid gives, respectively, methyl carboxylic esters and carboxylic acids.

  烷基苯基硫化物在控制的温度下与磺酰氯和吡啶转化为1,1-二氯烷基苯基硫化物或1-氯烷基-1-烯基硫化物；用甲醇-水（1％v / v）和乙酸汞（II）-甲酸处理这些中间体，分别得到甲基羧酸酯和羧酸。
• .ALPHA.-Fluorination of Methyl Phenyl Sulfoxide and Related Compounds by Molecular Fluorine: A Novel Method for the Introduction of Fluorine into Sulfoxides Bearing .ALPHA.-H Atoms.
  作者：Akemi TOYOTA、Yoshinori ONO、Jun CHIBA、Takumichi SUGIHARA、Chikara KANEKO

  DOI：10.1248/cpb.44.703

  日期：——

  Direct formation of α-fluorosulfones from sulfoxides bearing α-H atoms merely by reaction with molecular fluorine (5% F2/N2) is reported, and a novel non-Pummerer-type mechanism is proposed for this α-fluorination reaction.

  据报道，通过与分子氟（5% F2/N2）反应，仅直接从含有α-H原子的亚砜生成α-氟磺醚，为此α-氟化反应提出了一种新型非Pummerer型机理。
• SUBSTITUTED GAMMA LACTAMS AS THERAPEUTIC AGENTS
  申请人：Old David W.

  公开号：US20100093729A1

  公开（公告）日：2010-04-15

  A compound comprising or a pharmaceutically acceptable salt, prodrug, or a metabolite thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments related to these compounds are also disclosed.

  本文揭示了一种包含或其药用可接受的盐、前药或代谢产物的化合物。Y、A和B如本文所述。还公开了与这些化合物相关的方法、组合物和药物。
• Therapeutic Compounds
  申请人：Donde Yariv

  公开号：US20090281104A1

  公开（公告）日：2009-11-12

  Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein J, B, Y, and A are as described. Methods, compositions, and medicaments related thereto are also disclosed.

  本发明涉及包含J、B、Y和A的化合物，或其药用可接受的盐或前药。同时还公开了相关的方法、组合物和药物。