2-amino-3,3,5-trimethyl-3,4-dihydro-2H-pyrrole-1-oxide | 1072938-25-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 2-amino-3,3,5-trimethyl-3,4-dihydro-2H-pyrrole-1-oxide
• 英文别名: 3,3,5-Trimethyl-1-oxido-2,4-dihydropyrrol-1-ium-2-amine；3,3,5-trimethyl-1-oxido-2,4-dihydropyrrol-1-ium-2-amine
• CAS: 1072938-25-0
• 化学式: C₇H₁₄N₂O
• 分子量: 142.201
• InChiKey: REHCRAMSIUZBFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  54.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-amino-3,3,5-trimethyl-3,4-dihydro-2H-pyrrole-1-oxide 、 苯甲醛 以 乙醚 为溶剂， 反应 5.0h， 以67%的产率得到2-(benzylideneamino)-3,3,5-trimethyl-3,4-dihydro-2H-pyrrole-1-oxide
  参考文献：
  名称：

  Allenyloxime—a new source of heterocyclizations to stable cyclic nitrones

  摘要：

  A variety of conditions including reductive and/or basic reagents in aqueous or alcoholic solution was applied to 2,2-dimethylpenta-3,4-dienal oxime. Formation of various five-membered heterocycles with excellent chemical selectivity was observed. Most of the reactions yielded cyclic nitrones with stable dipolar structure and unique functionalities present. All products of cyclization were isolated and fully characterized. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.113
• 作为产物：
  描述：

  2,2-dimethylpenta-3,4-dienal oxime 在 氨 作用下， 以 水 为溶剂， 反应 24.0h， 以71%的产率得到2-amino-3,3,5-trimethyl-3,4-dihydro-2H-pyrrole-1-oxide
  参考文献：
  名称：

  Allenyloxime—a new source of heterocyclizations to stable cyclic nitrones

  摘要：

  A variety of conditions including reductive and/or basic reagents in aqueous or alcoholic solution was applied to 2,2-dimethylpenta-3,4-dienal oxime. Formation of various five-membered heterocycles with excellent chemical selectivity was observed. Most of the reactions yielded cyclic nitrones with stable dipolar structure and unique functionalities present. All products of cyclization were isolated and fully characterized. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.113

文献信息

• Allenyloxime—a new source of heterocyclizations to stable cyclic nitrones
  作者：Marian Buchlovič、Stanislav Man、Milan Potáček

  DOI：10.1016/j.tet.2008.07.113

  日期：2008.10

  A variety of conditions including reductive and/or basic reagents in aqueous or alcoholic solution was applied to 2,2-dimethylpenta-3,4-dienal oxime. Formation of various five-membered heterocycles with excellent chemical selectivity was observed. Most of the reactions yielded cyclic nitrones with stable dipolar structure and unique functionalities present. All products of cyclization were isolated and fully characterized. (C) 2008 Elsevier Ltd. All rights reserved.