2-(3,5-dibenzyloxyphenyl)-4,6-dimethoxybenzofuran | 863310-51-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-(3,5-dibenzyloxyphenyl)-4,6-dimethoxybenzofuran
• 英文别名: 2-[3,5-Bis(phenylmethoxy)phenyl]-4,6-dimethoxy-1-benzofuran；2-[3,5-bis(phenylmethoxy)phenyl]-4,6-dimethoxy-1-benzofuran
• CAS: 863310-51-4
• 化学式: C₃₀H₂₆O₅
• 分子量: 466.533
• InChiKey: SNZKQNYUNVJSRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(3,5-dibenzyloxyphenyl)-4,6-dimethoxybenzofuran 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以36 mg的产率得到5-(4,6-二甲氧基苯并呋喃-2-基)-1,3-苯二酚
  参考文献：
  名称：

  A Short-step Convenient Synthesis of 2-Phenylbenzofuran from 3-Phenylcoumarin

  摘要：

  The reaction mechanism of chemical conversion of (E)-beta-[2-hydroxylphenylcthylene]benzeneethanol into 2-phenylbenzofuran by DDQ, which involves loss of one carbon unit, was characterized and described. Five naturally occurring 2-phenylbenzofurans of not only the isoflavonoid but also stilbenoid origin were synthesized by use of this chemical scheme, which proved that this new scheme is a useful tool for quick synthesis of 2-phenylbenzofurans.

  DOI：

  10.3987/com-05-10424
• 作为产物：
  描述：

  (E)-β-[2-hydroxy-4,6-dimethoxyphenylethylene]-3,5-dibenzyloxybenzeneethanol 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 苯 为溶剂， 反应 7.5h， 以36%的产率得到2-(3,5-dibenzyloxyphenyl)-4,6-dimethoxybenzofuran
  参考文献：
  名称：

  A Short-step Convenient Synthesis of 2-Phenylbenzofuran from 3-Phenylcoumarin

  摘要：

  The reaction mechanism of chemical conversion of (E)-beta-[2-hydroxylphenylcthylene]benzeneethanol into 2-phenylbenzofuran by DDQ, which involves loss of one carbon unit, was characterized and described. Five naturally occurring 2-phenylbenzofurans of not only the isoflavonoid but also stilbenoid origin were synthesized by use of this chemical scheme, which proved that this new scheme is a useful tool for quick synthesis of 2-phenylbenzofurans.

  DOI：

  10.3987/com-05-10424

文献信息

• A Short-step Convenient Synthesis of 2-Phenylbenzofuran from 3-Phenylcoumarin
  作者：Takeshi Kinoshita、Koji Ichinose

  DOI：10.3987/com-05-10424

  日期：——

  The reaction mechanism of chemical conversion of (E)-beta-[2-hydroxylphenylcthylene]benzeneethanol into 2-phenylbenzofuran by DDQ, which involves loss of one carbon unit, was characterized and described. Five naturally occurring 2-phenylbenzofurans of not only the isoflavonoid but also stilbenoid origin were synthesized by use of this chemical scheme, which proved that this new scheme is a useful tool for quick synthesis of 2-phenylbenzofurans.