1-methylindan-2-one | 35587-60-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1-methylindan-2-one
• 英文别名: 1-methyl-1,3-dihydro-2H-inden-2-one；1-methyl-1H-inden-2(3H)-one；1-Methyl-2-indanone；1-methyl-indan-2-one；2-Oxo-1-methyl-hydrinden；1-Methyl-hydrindon-(2)；1-methyl-1,3-dihydroinden-2-one
• CAS: 35587-60-1
• 化学式: C₁₀H₁₀O
• mdl: MFCD22196376
• 分子量: 146.189
• InChiKey: XVFJKYPFHFHIOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-methylindan-2-one 以 乙醚 、 二氯甲烷 为溶剂， 反应 1.5h， 生成
  参考文献：
  名称：

  Reactions of Phenyltriazolinedione with Alkenes. Stereochemistry of Methanol Adducts to Aziridinium Imide Intermediates

  摘要：

  The addition of 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) and the stereochemistry of methanol/PTAD adduct formation with cis- and trans-2-butenes, 1-methylcyclopentene, (E)-2-methyl-2-butene-1,1,1-d(3), and substituted indenes (indene, 2-methylindene, 2,3-dimethylindene) have been investigated. There is no loss of stereochemistry in the addition of MeOH and PTAD to butenes, 1-methylcyclopentene, 2-methyl-2-butene, and indene. However, in methyl-substituted indenes 9 and 14, loss of stereochemistry at the reaction center is observed. An aziridinium imide (AI) is proposed as an intermediate in all these systems. The stability of the AI intermediate and its equilibration with an open zwitterion depend on the particular system. Only in the benzylically-stabilized tertiary indenes is the open zwitterion stable enough to cause loss of stereochemistry.

  DOI：

  10.1021/ja00132a006
• 作为产物：
  描述：

  2-苯基丙酸 在 dirhodium tetraacetate 氯化亚砜 作用下， 以 乙醚 、 正己烷 、 二氯甲烷 为溶剂， 反应 10.75h， 生成 1-methylindan-2-one
  参考文献：
  名称：

  Sudrik; Nanjundiah; Sonawane, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1997, vol. 36, # 12, p. 1103 - 1112

  摘要：

  DOI：

文献信息

• [EN] SPIROLACTAM CGRP RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEUR DE CGRP À BASE DE SPIROLACTAME
  申请人：MERCK SHARP & DOHME

  公开号：WO2013169567A1

  公开（公告）日：2013-11-14

  The present invention is directed to spirolactam analogues which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及螺内酰胺类似物，其为CGRP受体拮抗剂，可用于治疗或预防涉及CGRP的疾病，如偏头痛。该发明还涉及包含这些化合物的药物组合物，以及在预防或治疗涉及CGRP的这类疾病中使用这些化合物和组合物。
• Biarylphosphonite Gold(I) Complexes as Superior Catalysts for Oxidative Cyclization of Propynyl Arenes into Indan-2-ones
  作者：Guilhem Henrion、Thomas E. J. Chavas、Xavier Le Goff、Fabien Gagosz

  DOI：10.1002/anie.201301015

  日期：2013.6.10

  Striking gold: A series of variously functionalized propynyl arenes was smoothly converted into indan‐2‐ones by a new gold(I)‐catalyzed oxidative cyclization process. [LAu]NTf2 (Tf=trifluoromethanesulfonyl) is a superior catalyst both in terms of yield and kinetics for the present transformation.

  打击金：通过新的金（I）催化的氧化环化工艺，一系列功能化的丙炔基芳烃被顺利转化为茚满-2-酮。就本转化而言，就收率和动力学而言，[ L Au] NTf 2（Tf ＝三氟甲磺酰基）是优良的催化剂。
• [EN] PRMT5 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE PRMT5 ET LEURS UTILISATIONS
  申请人：EPIZYME INC

  公开号：WO2014100716A1

  公开（公告）日：2014-06-26

  Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

  本文描述了式（A）的化合物，其药学上可接受的盐以及药物组合物。本发明的化合物对抑制PRMT5活性是有用的。还描述了利用这些化合物治疗PRMT5介导的疾病的方法。
• Central nervous system active compounds. IV. Synthesis of 3-aminobenzylphthalides
  作者：GI Hutchison、PA Marshall、RH Prager、JM Tippett、AD Ward

  DOI：10.1071/ch9802699

  日期：——

  Several 3-aminobenzylphthalides have been prepared by reactions of 3- (2-oxo-1-phenylpropyl)-phthalides with hydrazoic acid or by the Beckmann rearrangement. The corresponding reactions with 3-(2- oxoindanyl)phthalides showed limited success but led to a new synthesis of phthalide-isoquinoline alkaloids. Preliminary biological testing of some of these derivatives indicates that they only have weak central nervous system activity.

  几种 通过 3- (2-氧代-1-苯基丙基)邻苯二甲酸与苯甲酸的反应，或通过贝克曼 重排。与 3-(2-氧代茚基)邻苯二甲酸盐的相应反应 的相应反应显示出有限的成功，但却导致了邻苯二甲酰异喹啉生物碱的新合成。 生物碱。对其中一些衍生物的初步生物测试表明 表明，它们只具有微弱的中枢神经系统活性。
• Antidepressant imidazolines and related compounds
  申请人：Sterling Drug Inc.

  公开号：US04540705A1

  公开（公告）日：1985-09-10

  2-(2-Naphthalenyl)alkyl-4,5-dihydro-1H-imidazoles and -tetrahydropyrimidines, the corresponding 3,4-dihydronaphthalenyl and 1,2,3,4-tetrahydronaphthalenyl compounds; and the corresponding indene and indane derivatives, useful as antidepressant or diuretic agents, are prepared by reacting the appropriate 2-(cyanoalkyl)naphthalene or -indane derivative (or the corresponding ester or imino-ether) with an alkylenediamine.

  2-(2-萘基)烷基-4,5-二氢-1H-咪唑和-四氢嘧啶，相应的3,4-二氢萘基和1,2,3,4-四氢萘基化合物；以及相应的茚和茚烷衍生物，可用作抗抑郁或利尿剂，通过将适当的2-(氰基烷基)萘烯或-茚烷衍生物（或相应的酯或亚胺醚）与烷二胺反应制备。