2-phenoxy-2,3-dihydro-1H-inden-1-one | 900492-77-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-phenoxy-2,3-dihydro-1H-inden-1-one
• 英文别名: 2-Phenoxy-indan-1-one；2-phenoxy-2,3-dihydroinden-1-one
• CAS: 900492-77-5
• 化学式: C₁₅H₁₂O₂
• 分子量: 224.259
• InChiKey: VNZLRRDCSJLAPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-phenoxy-2,3-dihydro-1H-inden-1-one 在 sodium hydroxide 、 异丙醇 作用下， 反应 2.0h， 以43%的产率得到2-phenoxy-2,3-dihydro-1H-inden-1-ol
  参考文献：
  名称：

  Biomimetic transfer hydrogenation of 2-alkoxy- and 2-aryloxyketones with iron–porphyrin catalysts

  摘要：

  In situ generated iron porphyrins are applied as homogeneous catalysts in the transfer hydrogenation of a-substituted ketones. Using 2-propanol as hydrogen donor various protected 1, 2-hydroxyketones are reduced to the corresponding mono-substituted 1,2-diols in good to excellent yield. Under optimized reaction conditions catalyst turnover frequencies up to 2500 h(-1) have been achieved. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.083
• 作为产物：
  描述：

  2-溴-1-茚满酮 、 苯酚 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 16.0h， 以56%的产率得到2-phenoxy-2,3-dihydro-1H-inden-1-one
  参考文献：
  名称：

  Biomimetic transfer hydrogenation of 2-alkoxy- and 2-aryloxyketones with iron–porphyrin catalysts

  摘要：

  In situ generated iron porphyrins are applied as homogeneous catalysts in the transfer hydrogenation of a-substituted ketones. Using 2-propanol as hydrogen donor various protected 1, 2-hydroxyketones are reduced to the corresponding mono-substituted 1,2-diols in good to excellent yield. Under optimized reaction conditions catalyst turnover frequencies up to 2500 h(-1) have been achieved. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.083

文献信息

• [EN] NOVEL COMPOUNDS FOR SKIN LIGHTENING<br/>[FR] NOUVEAUX COMPOSÉS POUR L'ÉCLAIRCISSEMENT DE LA PEAU
  申请人：UNILEVER GLOBAL IP LTD

  公开号：WO2021037759A1

  公开（公告）日：2021-03-04

  A novel compound is disclosed. Skin lightening composition comprising said compound and method of skin lightening is disclosed too. In addition, method of synthesizing said novel compound is disclosed.

  揭示了一种新的化合物。还揭示了包括该化合物的美白皮肤组合物和美白皮肤的方法。此外，还揭示了合成该新化合物的方法。
• [EN] NOVEL COMPOUNDS FOR SKIN LIGHTENING<br/>[FR] NOUVEAUX COMPOSÉS POUR ÉCLAIRCISSEMENT DE LA PEAU
  申请人：UNILEVER GLOBAL IP LTD

  公开号：WO2021037750A1

  公开（公告）日：2021-03-04

  Novel compounds are disclosed. Skin lightening composition comprising said compounds and method of skin lightening is disclosed too. In addition, method of synthesizing said novel compounds are disclosed.

  本发明揭示了新化合物。还揭示了包含该化合物的美白组合物和美白方法。此外，还揭示了合成该新化合物的方法。
• Nicotine in therapeutic angiogenesis and vasculogenesis
  申请人：Cooke John

  公开号：US20060182731A1

  公开（公告）日：2006-08-17

  The present invention features methods for induction of angiogenesis by administration of nicotine or other nicotine receptor agonist. Induction of angiogenesis by the methods of the invention can be used in therapeutic angiogenesis in, for example, treatment of ischemic syndromes such as coronary or peripheral arterial disease.

  本发明的特点是通过服用尼古丁或其他尼古丁受体激动剂诱导血管生成的方法。通过本发明的方法诱导血管生成可用于治疗性血管生成，例如治疗冠状动脉或外周动脉疾病等缺血性综合征。
• NOVEL COMPOUNDS FOR SKIN LIGHTENING
  申请人：Unilever Global IP Limited

  公开号：EP4021391A1

  公开（公告）日：2022-07-06
• US7598275B2
  申请人：——

  公开号：US7598275B2

  公开（公告）日：2009-10-06