5-chloro-2-(4-phenoxyphenyl)furo[3,2-h]quinoline | 1445515-39-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 5-chloro-2-(4-phenoxyphenyl)furo[3,2-h]quinoline
• 英文别名: 5-Chloro-2-(4-phenoxyphenyl)furo[3,2-h]quinoline
• CAS: 1445515-39-8
• 化学式: C₂₃H₁₄ClNO₂
• 分子量: 371.823
• InChiKey: RRTCRKLVHYDGQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  氯碘羟喹 、 4-苯氧基苯乙炔 在 二(氰基苯)二氯化钯 、 2-pyridinecarboxaldehyde N-methyl-N-phenylhydrazone 、 十六烷基三甲基溴化铵 、 N,N-二异丙基乙胺 作用下， 反应 1.0h， 以87%的产率得到5-chloro-2-(4-phenoxyphenyl)furo[3,2-h]quinoline
  参考文献：
  名称：

  A green approach for highly regioselective syntheses of furo[3,2-h]quinolines in aqueous medium

  摘要：

  An environmentally benign, high yielding, and operationally simple protocol has been developed for the regioselective synthesis of furo[3,2-h]quinolines in aqueous micellar medium involving Cu-free domino Sonogashira reaction followed by 5-endo-dig-cyclization of substituted 8-hydroxyquinolines and terminal allcyne by using Pd(C6H5CN)Cl-2 as catalyst and 2-pyridinecarboxaldehyde methylphenyl hydrazone as ligand under aerobic condition. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.05.038

文献信息

• A green approach for highly regioselective syntheses of furo[3,2-h]quinolines in aqueous medium
  作者：Swarbhanu Sarkar、Rammyani Pal、Nivedita Chatterjee、Samrat Dutta、Subhendu Naskar、Asish Kumar Sen

  DOI：10.1016/j.tetlet.2013.05.038

  日期：2013.7

  An environmentally benign, high yielding, and operationally simple protocol has been developed for the regioselective synthesis of furo[3,2-h]quinolines in aqueous micellar medium involving Cu-free domino Sonogashira reaction followed by 5-endo-dig-cyclization of substituted 8-hydroxyquinolines and terminal allcyne by using Pd(C6H5CN)Cl-2 as catalyst and 2-pyridinecarboxaldehyde methylphenyl hydrazone as ligand under aerobic condition. (C) 2013 Elsevier Ltd. All rights reserved.