4,4-Dimethyl-2,3-dihydro-γ-pyran | 64833-72-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环化合物
• 英文名称: 4,4-Dimethyl-2,3-dihydro-γ-pyran
• 英文别名: 4,4-Dimethyl-3,4-dihydro-2H-pyran；4,4-dimethyl-2,3-dihydropyran
• CAS: 64833-72-3
• 化学式: C₇H₁₂O
• 分子量: 112.172
• InChiKey: JNHSLLWORMFHKQ-UHFFFAOYSA-N

物化性质

• 沸点：
  131.3±10.0 °C(Predicted)
• 密度：
  0.868±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4,4-Dimethyl-2,3-dihydro-γ-pyran 在 盐酸 草酰氯 、 四氯化钛 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.75h， 生成
  参考文献：
  名称：

  Room Temperature Intramolecular Hydro-O-alkylation of Aldehydes:  sp³ C−H Functionalization via a Lewis Acid Catalyzed Tandem 1,5-Hydride Transfer/Cyclization

  摘要：

  The scope and limitations of intramolecular hydro-O-alkylation of aldehyde substrates leading to spiroketals and bicyclic ketals and aminals is reported. The direct transformation of tertiary and sterically hindered secondary sp(3) C-H bonds into C-O bonds under the action of a catalytic amount of a variety of Lewis acids is described. The mechanism of these transformations is proposed to involve a tandem hydride transfer/cyclization sequence.

  DOI：

  10.1021/ol0522283
• 作为产物：
  描述：

  4,4-dimethyltetrahydro-2H-pyran-2-ol 在 对甲苯磺酸 作用下， 以 喹啉 为溶剂， 反应 1.5h， 以220 mg的产率得到4,4-Dimethyl-2,3-dihydro-γ-pyran
  参考文献：
  名称：

  [EN] PYRAZOLO[1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
  [FR] COMPOSÉS DE PYRAZOLO[1,5-A]PYRIMIDINYL CARBOXAMIDE ET LEUR UTILISATION DANS LE TRAITEMENT DE TROUBLES MÉDICAUX

  摘要：

  本发明提供了取代的吡唑[1,5-a]嘧啶基甲酰胺及其相关有机化合物，包含此类化合物的组合物，医疗包，以及使用此类化合物和组合物治疗医疗障碍的方法，例如，戈谢病，帕金森病，路易体病，痴呆症或多系统萎缩症。所述的代表性的取代吡唑[1,5-a]嘧啶基甲酰胺化合物包括2-杂环基-4-烷基-吡唑[1,5-a]嘧啶-3-甲酰胺化合物及其变体。

  公开号：

  WO2017176960A1

文献信息

• ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY
  申请人：Tamura Yuusuke

  公开号：US20120015961A1

  公开（公告）日：2012-01-19

  The present invention provides, for example, a compound of the following formula (I): wherein R 1 is substituted amino and the like, R 2 is halogen and the like, R 3 is substituted or unsubstituted lower alkyl and the like, R A and R B are each independently hydrogen, substituted or unsubstituted lower alkyl and the like, R C and R D are each independently hydrogen, substituted or unsubstituted lower alkyl, or R C and R D together with the carbon atom to which they are attached may form a substituted or unsubstituted carbocycle, and ring A is a carbocycle or a heterocycle, its pharmaceutically acceptable salt, or a solvate thereof as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-βproteins.

  本发明提供了以下式（I）的化合物，例如： 其中R 1 是取代氨基等， R 2 是卤素等， R 3 是取代或未取代的较低烷基等， R A 和R B 各自独立地是氢、取代或未取代的较低烷基等， R C 和R D 各自独立地是氢、取代或未取代的较低烷基，或R C 和R D 与它们连接的碳原子一起可以形成取代或未取代的碳环，以及 环A是碳环或杂环， 其药学上可接受的盐，或其溶剂合物作为由淀粉样蛋白β的产生、分泌和/或沉积引起的疾病的治疗剂。
• Reaction of singlet oxygen with 4-methyl-2,3-dihydro-.gamma.-pyrans
  作者：Aryeh A. Frimer、Paul D. Bartlett、Andre F. Boschung、John G. Jewett

  DOI：10.1021/ja00466a033

  日期：1977.11

  yield both a dioxetane 2 and an allylic hydroperoxide 3, each of which is converted by heat into a single product stable under conditions of vapor chromatography. The product composition from 1 and from 1-4-d has been determined in benzene and in acetonitrile, the ratio 2/3 being 26 times greater in the latter solvent. The tritium kinetic isotope effects at the ..cap alpha..,..beta.., and ..gamma.. positions

  4-甲基-1,3-二氢-..γ..-吡喃 (1) 与单线态分子氧反应生成二氧杂环丁烷 2 和烯丙基氢过氧化物 3，其中每一种都通过加热转化为稳定的单一产品气相色谱条件。1 和 1-4-d 的产物组成已在苯和乙腈中测定，2/3 的比率在后一种溶剂中高 26 倍。..cap alpha..、..beta.. 和..gamma.. 位置的氚动力学同位素效应表明，对于两种溶剂中的两种产物，过渡态的 HC/sup ..gamma../债券，加强的 HC/sup ..beta../ 债券，以及强度没有明显改变的 HC/sup ..cap alpha../ 债券。
• Iridium-catalyzed Vinylic C–H Borylation of Cyclic Vinyl Ethers by Bis(pinacolato)diboron
  作者：Takao Kikuchi、Jun Takagi、Tatsuo Ishiyama、Norio Miyaura

  DOI：10.1246/cl.2008.664

  日期：2008.6.5

  Vinylic C–H borylation of cyclic vinyl ethers by bis(pinacolato)diboron was effectively catalyzed by iridium complexes comprised of 1/2[Ir(OMe)(cod)]2 and 4,4′-di-tert-butyl-2,2′-bipyridine in hexane or octane to give the corresponding vinylboron compounds in good yields. The reaction of 1,4-dioxene occurred even at room temperature, whereas the reactions of dihydropyran and dihydrofuran derivatives required a temperature above 80 °C. Although dihydropyran and dihydrofuran themselves produced regioisomeric mixtures of α- and β-borylated products, similar substrates possessing substituents at the γ-position selectively underwent borylation at the α-position.

  由 1/2[Ir(OMe)(cod)]2 和 4,4′-二叔丁基-2,2′-联吡啶组成的铱配合物在己烷或辛烷中有效催化了双(频哪醇)二硼酸环乙烯基醚的乙烯基 C-H 硼酸化反应，从而以良好的收率得到了相应的乙烯基硼化合物。1,4-dioxene 的反应甚至可以在室温下进行，而二氢吡喃和二氢呋喃衍生物的反应则需要 80 °C 以上的温度。虽然二氢吡喃和二氢呋喃本身会产生α-和β-硼化产物的区域异构混合物，但在γ-位上具有取代基的类似底物会选择性地在α-位上发生硼化反应。
• Metal-Catalyzed Reactions of Organoboronic Acids and Esters
  作者：Norio Miyaura

  DOI：10.1246/bcsj.81.1535

  日期：2008.12.15

  Metal-catalyzed B–C and C–C bond-forming reactions of organoboronic acids that have been pursued in the past three decades by our group are summarized in this article. B–C bond-forming reactions fo...

  本文总结了我们小组在过去 30 年中一直在金属催化的有机硼酸的 B-C 和 C-C 键形成反应。B-C键形成反应...
• Low solvent content type-resin composition, coating composition containing such resin composition and process for coating such coating composition
  申请人：MAZDA MOTOR CORPORATION

  公开号：EP0688841A2

  公开（公告）日：1995-12-27

  The present invention is to provide a low solvent content type-coating composition by which the resultant coatings with good scuff resistance or water resistance as well as good chipping resistance are produced, while the content of an organic solvent to be used can be much reduced. The low solvent content type-coating composition comprises a polyester oligomer having a hydroxyl group in an amount of 2.0 to 10.0 moles/Kg-resin, a number average molecular weight (Mn) of 300 to 1500, a weight average molecular weight (Mw) of 300 to 3000, and a ratio of a weight average molecular weight/a number average molecular weight (Mw/Mn) of 1 to 2.0, an amount of a modifying lactone being 31 to 85%, and an aliphatic hydrocarbon group of C4-22 which is not derived from lactones. The present invention is also to provide a process for coating a low solvent content type-coating composition on, for example, a base coating composition by a wet-on-wet coating. The base coating composition comprises a vinyl oligomer having a hydroxyl group and/or a blocked hydroxyl group, a melamine resin containing 50 to 100% of an imino type or methylol type mononucleus melamine and a weak acidic curing catalyst.

  本发明旨在提供一种低溶剂含量型涂料组合物，通过该组合物可生产出具有良好耐磨擦性或耐水性以及良好抗崩角性的涂料，同时可大大减少所用有机溶剂的含量。低溶剂含量型涂料组合物包括具有羟基的聚酯低聚物，其羟基含量为 2.0 至 10.0 摩尔/Kg-树脂，数均分子量（Mn）为 300 至 1500，重量平均分子量（Mw）为 300 至 3000，重量平均分子量/数均分子量之比（Mw/Mn）为 1 至 2.0，改性内酯的含量为 31 至 85%，以及不来自内酯的 C4-22 脂肪族烃基。本发明还提供一种通过湿对湿涂覆法在例如基底涂料组合物上涂覆低溶剂含量型涂料组合物的工艺。基底涂料组合物包括具有羟基和/或封端羟基的乙烯基低聚物、含有 50%至 100%亚氨基型或甲醇型单核三聚氰胺的三聚氰胺树脂和弱酸性固化催化剂。