1-propionyl-3-phenyl-5-(4-methoxyphenyl)-2-pyrazoline | 496845-50-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-propionyl-3-phenyl-5-(4-methoxyphenyl)-2-pyrazoline
• 英文别名: 1-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]propan-1-one
• CAS: 496845-50-2
• 化学式: C₁₉H₂₀N₂O₂
• 分子量: 308.38
• InChiKey: UUFYFLSFNOPPKX-UHFFFAOYSA-N

物化性质

• 熔点：
  84-86 °C
• 沸点：
  458.2±55.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲氧基查耳酮 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 1-propionyl-3-phenyl-5-(4-methoxyphenyl)-2-pyrazoline
  参考文献：
  名称：

  Synthesis ofN-Acyl Triazolyl-Pyrazolines via Acylation Initiated by the Hydrazone Moiety with Carboxylic Acids

  摘要：

  An efficient synthesis of N-acyl/N-substituted acyl pyrazolines and their triazole hybrids have been accomplished via acylation of pyrazolines and pyrazoline-triazole hybrids with carboxylic acids and/or substituted carboxylic acids in the absence of activating agents/catalysts. In the present study, a mechanism envisaging the in situ generation of a new transient acylating intermediate has been proposed to explain the acylation.

  DOI：

  10.1080/00397911.2015.1104357

文献信息

• Abbas, Asghar; Naseer, Muhammad Moazzam, Acta Chimica Slovenica, 2014, vol. 61, # 4, p. 792 - 802
  作者：Abbas, Asghar、Naseer, Muhammad Moazzam

  DOI：——

  日期：——
• Synthesis of<i>N</i>-Acyl Triazolyl-Pyrazolines via Acylation Initiated by the Hydrazone Moiety with Carboxylic Acids
  作者：Archana Sivasubramaniyan、Dinesh Murugan、Ranganathan Raja、Sathishkumar Murugan、Shanmugavelan Poovan、Ponnuswamy Alagusundaram

  DOI：10.1080/00397911.2015.1104357

  日期：2015.12.2

  An efficient synthesis of N-acyl/N-substituted acyl pyrazolines and their triazole hybrids have been accomplished via acylation of pyrazolines and pyrazoline-triazole hybrids with carboxylic acids and/or substituted carboxylic acids in the absence of activating agents/catalysts. In the present study, a mechanism envisaging the in situ generation of a new transient acylating intermediate has been proposed to explain the acylation.