N^α-hexadecanoyl-L-histidine | 55258-12-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N^α-hexadecanoyl-L-histidine
• 英文别名: NoName_3984；2-(hexadecanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
• CAS: 55258-12-3；133849-44-2
• 化学式: C₂₂H₃₉N₃O₃
• 分子量: 393.57
• InChiKey: XHUZOURAPKCNRA-UHFFFAOYSA-N

物化性质

• 沸点：
  638.4±50.0 °C(Predicted)
• 密度：
  1.048±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  28
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  95.1
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  棕榈酰氯 、 D,L-histidine 生成 N^α-hexadecanoyl-L-histidine
  参考文献：
  名称：

  Ueoka, Ryuichi; Murakami, Yukito, Journal of the Chemical Society. Perkin transactions II, 1983, p. 219 - 224

  摘要：

  DOI：

文献信息

• COMPOSITION FOR EXTERNAL APPLICATION
  申请人：Rohto Pharmaceutical Co., Ltd.

  公开号：EP3210613A1

  公开（公告）日：2017-08-30

  An object of the present invention is to provide an external use composition having a novel composition that has a superior effect promoting collagen production and is able to suppress, prevent or improve wrinkles and sagging of the skin with aging. The present invention relates to an external use composition for anti-aging, comprising (A) a lipopeptide represented by the following formula (1), or a pharmaceutically acceptable salt thereof: (wherein, R1 represents a saturated aliphatic group, or aliphatic group having a single unsaturated bond, having 9 to 19 carbon atoms, and m represents 0 or 1).

  本发明的目的是提供一种外用组合物，该组合物具有新颖的成分，具有促进胶原蛋白生成的卓越效果，能够抑制、预防或改善随着衰老而出现的皱纹和皮肤松弛。 本发明涉及一种用于抗衰老的外用组合物，其中包括 (A) 下式（1）代表的脂肽或其药学上可接受的盐： (其中，R1 代表具有 9 至 19 个碳原子的饱和脂肪族基团或具有单个不饱和键的脂肪族基团，m 代表 0 或 1）。
• COATING FILM-FORMING COMPOSITION
  申请人：Nissan Chemical Corporation

  公开号：EP3808329A1

  公开（公告）日：2021-04-21

  There is provided a composition that can more readily form a coating film exhibiting excellent moisture-retaining property. A coating film-forming composition characterized by comprising at least one lipidic peptide compound composed of a low-molecular-weight lipidic peptide or a pharmaceutically usable salt thereof. The lipidic peptide compound may preferably be a compound prepared by bonding of a peptide moiety having an amino acid repeating structure to a lipidic moiety having a C9-23 aliphatic group.

  本发明提供了一种更易于形成具有优异保湿性能的涂膜的组合物。 一种涂膜成膜组合物，其特征在于包含至少一种由低分子量脂质肽或其药用盐组成的脂质肽化合物。 脂肽化合物最好是通过将具有氨基酸重复结构的肽分子与具有 C9-23 脂肪族基团的脂质分子键合而制备的化合物。
• Cream-like composition
  申请人：AJINOMOTO CO., INC.

  公开号：US10736826B2

  公开（公告）日：2020-08-11

  Creamy cleansing compositions and creamy compositions which contain (A) at least one component selected from the group consisting of N-acyl acidic amino acid and a salt thereof, and N-acyl neutral amino acid and a salt thereof, (B) at least one polyhydric alcohol, (C) at least one N-mono middle-chain acyl basic amino acid or a salt thereof, and (D) water have good creamy appearance with high grade pearly gloss, are superior in form stability, and superior in the sense of use such as cream elongation, water miscibility, and the like.

  乳状清洁组合物和乳状组合物含有(A)至少一种选自 N-酰基酸性氨基酸及其盐和 N-酰基中性氨基酸及其盐组成的组的成分，(B)至少一种多元醇，(C)至少一种 N-单中链酰基碱性氨基酸或其盐，以及(D)水、(C) 至少一种 N-单中链酰基碱性氨基酸或其盐，以及 (D) 水。这些成分具有良好的奶油外观和高级珠光光泽，在形态稳定性和使用感（如奶油延展性、水混溶性等）方面都更胜一筹。
• Composition for cosmetics and cosmetics comprising same
  申请人：AJINOMOTO CO., INC

  公开号：US10786437B2

  公开（公告）日：2020-09-29

  Compositions for cosmetics containing (A) one or more kinds of N-mono long-chain acyl basic amino acids, and (B) one or more kinds of N-mono middle-chain acyl basic amino acids, and compositions for cosmetics further containing (C) an inorganic powder, provide cosmetics that give, on application, a comfortable silky feeling and, to the skin after application, a natural translucency, good luminous finish and a uniform feeling of the skin surface, and have adhesiveness to the skin and high covering power.

  含有(A)一种或多种 N-单长链酰基碱性氨基酸和(B)一种或多种 N-单中链酰基碱性氨基酸的化妆品组合物，以及进一步含有(C)无机粉末的化妆品组合物，可提供涂抹时具有舒适的丝滑感，涂抹后皮肤具有自然的半透明性、良好的光洁度和皮肤表面的均匀感，并且对皮肤具有粘附性和高遮盖力的化妆品。
• Composition for external application
  申请人：ROHTO PHARMACEUTICAL CO., LTD.

  公开号：US10835572B2

  公开（公告）日：2020-11-17

  An object of the present invention is to provide an external use composition having a novel composition that has a superior effect promoting collagen production and is able to suppress, prevent or improve wrinkles and sagging of the skin with aging. The present invention relates to an external use composition for anti-aging, comprising (A) a lipopeptide represented by the following formula (1), or a pharmaceutically acceptable salt thereof: (wherein, R1 represents a saturated aliphatic group, or aliphatic group having a single unsaturated bond, having 9 to 19 carbon atoms, and m represents 0 or 1).

  本发明的目的是提供一种外用组合物，该组合物具有新颖的成分，具有促进胶原蛋白生成的卓越效果，能够抑制、预防或改善随着衰老而出现的皱纹和皮肤松弛。 本发明涉及一种用于抗衰老的外用组合物，其中包括 (A) 下式（1）代表的脂肽或其药学上可接受的盐： (其中，R1 代表饱和脂肪族基团，或具有单个不饱和键的脂肪族基团，具有 9 至 19 个碳原子，m 代表 0 或 1）。