2'-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine | 431890-07-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2'-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine
• 英文别名: 2-(4-nitrophenyl)ethyl N-[5-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-oxo-1,3,5-triazin-2-yl]carbamate
• CAS: 431890-07-2
• 化学式: C₁₇H₁₉N₅O₈
• 分子量: 421.367
• InChiKey: BKUHWMCGDJCZOX-BFHYXJOUSA-N

物化性质

• 密度：
  1.66±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  179
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2'-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine 生成
  参考文献：
  名称：

  Synthesis and Properties of Oligonucleotides Containing 5-Aza-2′-deoxycytidine

  摘要：

  The preparation of a protected derivative of 5-aza-2'-deoxycytidine carrying the 2-(p-nitrophenyl)ethyl group is described. The new derivative is useful for the preparation of oligonucleotides containing 5-aza-2'-deoxycytidine using a special methodology that avoids the use of ammonia.

  DOI：

  10.1080/07328319708006144
• 作为产物：
  描述：

  地西他滨 以 N,N-二甲基甲酰胺 为溶剂， 反应 96.0h， 生成 2'-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine
  参考文献：
  名称：

  Synthesis and Properties of Oligonucleotides Containing 5-Aza-2′-deoxycytidine

  摘要：

  The preparation of a protected derivative of 5-aza-2'-deoxycytidine carrying the 2-(p-nitrophenyl)ethyl group is described. The new derivative is useful for the preparation of oligonucleotides containing 5-aza-2'-deoxycytidine using a special methodology that avoids the use of ammonia.

  DOI：

  10.1080/07328319708006144

文献信息

• Methods and compositions for gene-specific demethylation by DNA methyltransferase (DNMT)-RNA interaction
  申请人：Di Ruscio Annalisa

  公开号：US10941399B2

  公开（公告）日：2021-03-09

  The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder.

  本发明涉及单链寡核苷酸嵌合 RNA 寡核苷酸。这些化合物能够靶向特定基因，降低 DNA 甲基转移酶的活性。因此，这些化合物特别适用于治疗与DNA甲基转移酶活性异常有关的疾病，如癌症或遗传性疾病。
• N4 MODIFICATIONS OF PYRIMIDINE ANALOGS AND USES THEREOF
  申请人：Yang Allen S.

  公开号：US20080234223A1

  公开（公告）日：2008-09-25

  The present invention relates to N4 carboxylester or ester derivatives of pyrimidine analogs with increased stability, solubility, and bioavailability. Also disclosed are methods of using these compounds for targeted drug delivery and combination therapy.
• COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES
  申请人：Johansen Lisa M.

  公开号：US20110028564A1

  公开（公告）日：2011-02-03

  The invention features compositions, methods, and kits useful for the treatment of filovirus-mediated diseases, e.g., hemorrhagic fever caused by Ebola virus, in an animal.
• CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF
  申请人：Di Ruscio Annalisa

  公开号：US20140171492A1

  公开（公告）日：2014-06-19

  The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder.
• US8475804B2
  申请人：——

  公开号：US8475804B2

  公开（公告）日：2013-07-02