The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder.
本发明涉及单链寡核苷酸嵌合 RNA 寡核苷酸。这些化合物能够靶向特定
基因,降低 DNA 甲基转移酶的活性。因此,这些化合物特别适用于治疗与DNA甲基转移酶活性异常有关的疾病,如癌症或遗传性疾病。