6-(3,4-dimethylphenyl)-N-(2H-tetrazol-5-yl)pyridine-2-carboxamide | 78296-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(3,4-dimethylphenyl)-N-(2H-tetrazol-5-yl)pyridine-2-carboxamide
• CAS: 78296-68-1
• 化学式: C₁₅H₁₄N₆O
• 分子量: 294.316
• InChiKey: TWKWHOGBTRBLSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  96.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-(3,4-Dimethyl-phenyl)-4-oxo-4H-pyran-2-carboxylic acid ethyl ester 在 palladium on activated charcoal 盐酸 、 氢氧化钾 、 氯化亚砜 、 氨 、 氢气 、 三乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 25.0~110.0 ℃ 、101.33 kPa 条件下， 反应 67.0h， 生成 6-(3,4-dimethylphenyl)-N-(2H-tetrazol-5-yl)pyridine-2-carboxamide
  参考文献：
  名称：

  Antiallergic agents. 2. N-(1H-Tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides

  摘要：

  A new series of N-(1H-tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides was prepared to determine the effects of substituents on the benzene and pyridine rings on antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) assay after oral administration. One member of this series, N-(1H-tetrazol-5-yl)-4-methyl-6-[4-(methylamino)-phenyl]-2- pyridinecarboxamide (231), has an ED50 value of 0.8 mg/kg po and is 85 times more potent than disodium cromoglycate (DSCG) on intravenous administration. Further evaluation of 231 as a clinically useful antiallergic agent is in progress.

  DOI：

  10.1021/jm00364a026

文献信息

• Antiallergic agents. 2. N-(1H-Tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides
  作者：Yasushi Honma、Kuniyuki Oda、Tomiki Hashiyama、Kyoji Hanamoto、Hideo Nakai、Hirozumi Inoue、Akihiko Ishida、Mikio Takeda、Yasutoshi Ono、Kei Tsuzurahara

  DOI：10.1021/jm00364a026

  日期：1983.10

  A new series of N-(1H-tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides was prepared to determine the effects of substituents on the benzene and pyridine rings on antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) assay after oral administration. One member of this series, N-(1H-tetrazol-5-yl)-4-methyl-6-[4-(methylamino)-phenyl]-2- pyridinecarboxamide (231), has an ED50 value of 0.8 mg/kg po and is 85 times more potent than disodium cromoglycate (DSCG) on intravenous administration. Further evaluation of 231 as a clinically useful antiallergic agent is in progress.