Bis<6-(1-oxo-2,2-dimethylpropyl)-2-pyridyl>methoxy<4-((tert-butyldimethylsilyl)oxo)phenyl>methane | 161584-89-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bis<6-(1-oxo-2,2-dimethylpropyl)-2-pyridyl>methoxy<4-((tert-butyldimethylsilyl)oxo)phenyl>methane
• 英文别名: 1-[6-[[4-[Tert-butyl(dimethyl)silyl]oxyphenyl]-[6-(2,2-dimethylpropanoyl)pyridin-2-yl]-methoxymethyl]pyridin-2-yl]-2,2-dimethylpropan-1-one
• CAS: 161584-89-0
• 化学式: C₃₄H₄₆N₂O₄Si
• 分子量: 574.836
• InChiKey: IVNYXIBFABPIEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.26
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  78.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Bis<6-(1-oxo-2,2-dimethylpropyl)-2-pyridyl>methoxy<4-((tert-butyldimethylsilyl)oxo)phenyl>methane 在 (-)-diisopinocamphenylborane chloride 作用下， 以 四氢呋喃 为溶剂， 生成 (R)-1-(6-{[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-[6-((R)-1-hydroxy-2,2-dimethyl-propyl)-pyridin-2-yl]-methoxy-methyl}-pyridin-2-yl)-2,2-dimethyl-propan-1-ol
  参考文献：
  名称：

  Preparation of Dipyridylmethane Ligands with Pseudo-C2 Symmetry. Grafting on Polystyrenes via Transformation to Phenolic Derivatives

  摘要：

  Efficient grafting of dipyridylmethane ligands on highly cross-linked as well as gel-type chloromethylated polystyrenes has been achieved using phenolic derivatives of the ligands. In this way, chiral polymer-supported ligands with pseudo-C-2 symmetry were obtained. The synthesis of the ligands and their grafting under mild conditions are described, as well as the preparation of monomeric models. During reduction of 6,6'-(2,2-dimethyl-1-oxopropyl) derivatives with sodium borohydride, the R,S isomers were unexpectedly formed with high selectivity.

  DOI：

  10.1021/jo00111a038
• 作为产物：
  描述：

  三甲基乙腈 、 Bis(6-bromo-2-pyridyl)methoxy<4-((tert-butyldimethylsilyl)oxy)phenyl>methane 在 正丁基锂 作用下， 以 乙醚 、 正己烷 为溶剂， 以83%的产率得到Bis<6-(1-oxo-2,2-dimethylpropyl)-2-pyridyl>methoxy<4-((tert-butyldimethylsilyl)oxo)phenyl>methane
  参考文献：
  名称：

  Preparation of Dipyridylmethane Ligands with Pseudo-C2 Symmetry. Grafting on Polystyrenes via Transformation to Phenolic Derivatives

  摘要：

  Efficient grafting of dipyridylmethane ligands on highly cross-linked as well as gel-type chloromethylated polystyrenes has been achieved using phenolic derivatives of the ligands. In this way, chiral polymer-supported ligands with pseudo-C-2 symmetry were obtained. The synthesis of the ligands and their grafting under mild conditions are described, as well as the preparation of monomeric models. During reduction of 6,6'-(2,2-dimethyl-1-oxopropyl) derivatives with sodium borohydride, the R,S isomers were unexpectedly formed with high selectivity.

  DOI：

  10.1021/jo00111a038

文献信息

• Preparation of Dipyridylmethane Ligands with Pseudo-C2 Symmetry. Grafting on Polystyrenes via Transformation to Phenolic Derivatives
  作者：Vincent Levacher、Christina Moberg

  DOI：10.1021/jo00111a038

  日期：1995.3

  Efficient grafting of dipyridylmethane ligands on highly cross-linked as well as gel-type chloromethylated polystyrenes has been achieved using phenolic derivatives of the ligands. In this way, chiral polymer-supported ligands with pseudo-C-2 symmetry were obtained. The synthesis of the ligands and their grafting under mild conditions are described, as well as the preparation of monomeric models. During reduction of 6,6'-(2,2-dimethyl-1-oxopropyl) derivatives with sodium borohydride, the R,S isomers were unexpectedly formed with high selectivity.