N-[(4-chlorophenyl)cyanomethyl]methanesulfonamide | 1020855-54-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(4-chlorophenyl)cyanomethyl]methanesulfonamide
• 英文别名: N-[(4-chlorophenyl)-cyanomethyl]methanesulfonamide
• CAS: 1020855-54-2
• 化学式: C₉H₉ClN₂O₂S
• 分子量: 244.702
• InChiKey: ALOWWJSNQQCEOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  78.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三甲基氰硅烷 、 N-(4-chlorobenzylidene)methanesulfonamide 在 NanoActive Plus magnesium oxide 作用下， 以 四氢呋喃 为溶剂， 反应 0.03h， 以92%的产率得到N-[(4-chlorophenyl)cyanomethyl]methanesulfonamide
  参考文献：
  名称：

  Synthesis of α-amino nitriles through Strecker reaction of aldimines and ketoimines by using nanocrystalline magnesium oxide

  摘要：

  Strecker reactions of various aldimines as well as ketoimines with TMSCN proceeded smoothly under mild conditions to give the corresponding alpha-amino nitriles and alpha,alpha-disubstituted alpha-amino nitriles, respectively, in good to excellent yields in the presence of nanocrystalline magnesium oxide. The reaction proceeds through hypervalent silicate species by coordination to O2-/O- (Lewis basic site) of nanocrystalline magnesium oxide, proved by Si-29 NMR. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.128

文献信息

• Synthesis of α-amino nitriles through Strecker reaction of aldimines and ketoimines by using nanocrystalline magnesium oxide
  作者：M. Lakshmi Kantam、Koosam Mahendar、Bojja Sreedhar、B.M. Choudary

  DOI：10.1016/j.tet.2008.01.128

  日期：2008.4

  Strecker reactions of various aldimines as well as ketoimines with TMSCN proceeded smoothly under mild conditions to give the corresponding alpha-amino nitriles and alpha,alpha-disubstituted alpha-amino nitriles, respectively, in good to excellent yields in the presence of nanocrystalline magnesium oxide. The reaction proceeds through hypervalent silicate species by coordination to O2-/O- (Lewis basic site) of nanocrystalline magnesium oxide, proved by Si-29 NMR. (C) 2008 Elsevier Ltd. All rights reserved.