N,N-diisopropylacrylamide | 44975-46-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-diisopropylacrylamide
• 英文别名: N,N-di(propan-2-yl)prop-2-enamide
• CAS: 44975-46-4
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: YHOSNAAUPKDRMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-diisopropylacrylamide 在 hexacarbonyl molybdenum 、 苯硅烷 作用下， 以 四氢呋喃 为溶剂， 反应 0.2h， 以95%的产率得到N,N-diisopropylpropionamide
  参考文献：
  名称：

  Silicon hydrides and molybdenum(0) catalyst: a novel approach for conjugate reduction of .alpha.,.beta.-unsaturated carbonyl compounds

  摘要：

  DOI：

  10.1021/jo00388a042
• 作为产物：
  描述：

  二异丙胺 、 丙烯酰氯 生成 N,N-diisopropylacrylamide
  参考文献：
  名称：

  从各种取代的以碳为中心的自由基中去除甲苯磺酰基的速率常数。

  摘要：

  使用自由基时钟方法已确定了从一系列以碳为中心的自由基中去除甲苯磺酰基自由基（Ts *）的速率常数。取决于Ts-CH（2）-CH * R基团中的取代基R，在293 K处的速率常数在10（3）-10（6）s（-1）范围内变化超过2个数量级。 。发现2-萘基和氨基甲酰基取代基的最小值最低，而苄基取代基位于另一个末端。取代基对起始自由基的稳定化作用在该反应中对降低断裂速率起主要作用。

  DOI：

  10.1021/jo026870b

文献信息

• Visible light-mediated difluoroalkylation of electron-deficient alkenes
  作者：Vyacheslav I Supranovich、Vitalij V Levin、Marina I Struchkova、Jinbo Hu、Alexander D Dilman

  DOI：10.3762/bjoc.14.139

  日期：——

  A method for the reductive difluoroalkylation of electron-deficient alkenes using 1,1-difluorinated iodides mediated by irradiation with blue light is described. The reaction involves radical addition of 1,1-difluorinated radicals at the double bond followed by hydrogen atom transfer from sodium cyanoborohydride.

  描述了一种方法，该方法使用由蓝光辐射介导的1，1-二氟碘化物来还原电子不足的烯烃的二氟烷基化。该反应包括在双键处自由基加成1，1-二氟自由基，然后从氰基硼氢化钠转移氢原子。
• Radical Silyldifluoromethylation of Electron-Deficient Alkenes
  作者：Vyacheslav I. Supranovich、Vitalij V. Levin、Marina I. Struchkova、Alexander A. Korlyukov、Alexander D. Dilman

  DOI：10.1021/acs.orglett.7b01334

  日期：2017.6.16

  A reaction of bromo- and iododifluoromethyl-substituted silanes with electron-deficient alkenes in the presence of an N-heterocyclic carbene borane complex is described. The reaction is performed under irradiation with light-emitting diodes and proceeds via a radical chain mechanism. The resulting products, the functionalized silicon reagents, can undergo chemoselective transformations involving either

  描述了在N-杂环卡宾硼烷配合物的存在下，溴和碘代二氟甲基取代的硅烷与缺电子的烯烃的反应。该反应在发光二极管的照射下进行，并通过自由基链机理进行。所得产物，即功能化的硅试剂，可以进行涉及甲硅烷基二氟甲基片段或官能团的化学选择性转化。
• NUCLEIC ACID PURIFICATION METHOD
  申请人：Erbacher Christoph

  公开号：US20110319506A1

  公开（公告）日：2011-12-29

  The present invention relates to a method for purifying nucleic acids using a nucleic acid-binding phase which is furnished with a deficit of nucleic acid-binding groups A having a pK of 8 to 13, or which has groups A and binding-inhibiting groups N which are neutrally charged during the binding, and preferably during the elution, and the method comprises the following steps: (a) binding the nucleic acids to the nucleic acid-binding phase at a pH which is below the pH of the pK of the nucleic acid-binding groups A (binding pH); (b) eluting the nucleic acids at a pH which is above the binding pH (elution pH). In addition, corresponding kits and also nucleic acid-binding phases which can be used for purifying nucleic acids are disclosed. The technology according to the invention permits the purification of nucleic acids and, in particular, elution, with use of low salt concentrations, and so the purified nucleic acids can be directly processed, for example used in a PCR.

  本发明涉及一种利用具有pK值为8至13的核酸结合基团A的核酸结合相或具有在结合期间和最好在洗脱期间呈中性电荷的基团A和结合抑制基团N的核酸结合相来纯化核酸的方法，该方法包括以下步骤：(a)在低于核酸结合基团A的pK值的pH下（结合pH）将核酸结合到核酸结合相上；(b)在高于结合pH的pH下（洗脱pH）洗脱核酸。此外，还公开了相应的用于纯化核酸的试剂盒和核酸结合相。根据本发明的技术允许纯化核酸，特别是在低盐浓度下进行洗脱，因此纯化的核酸可以直接处理，例如用于PCR。
• Palladium/nickel-mediated cross coupling reaction between phosphorylamides and alkenes toward enephosphorylamides
  作者：Zijian Zhao、Qiao Zhu、Shiying Che、Zhenghong Luo、Yan Lian

  DOI：10.1080/00397911.2020.1774903

  日期：2020.8.2

  prepared from phosphorylamides and substituted alkenes. The dehydrogenative transformation took place in the presence of a combination of a palladium diacetate and nickel dichloride. The transition metal-catalyzed methodology enjoyed high efficiency and broad substrate scope. Moreover, a plausible mechanism was proposed for the oxidative C–N cross coupling protocol. Graphical Abstract

  摘要 本文成功地以磷酰胺和取代烯烃为原料制备了烯磷酰胺。脱氢转化在二乙酸钯和二氯化镍的组合存在下发生。过渡金属催化方法具有高效和广泛的底物范围。此外，还为氧化 C-N 交叉耦合方案提出了一种合理的机制。图形概要
• Lewis acid promoted reactions of γ,γ-dialkoxyallylic zirconium species with various carbonyl compounds
  作者：Hisanaka Ito、Azusa Sato、Takeo Taguchi

  DOI：10.1016/j.tet.2005.09.009

  日期：2005.11

  The reactions of γ,γ-dialkoxyallylic zirconium species with carbonyl compounds in the presence of Lewis acid are reported. The reactivity of γ,γ-dialkoxyallylic zirconium species and reaction pathway were strongly dependent on the structure and electrostatic nature of the carbonyl compounds.

  报道了在路易斯酸存在下，γ,γ-二烷氧基烯丙基锆与羰基化合物的反应。γ,γ-二烷氧基烯丙基锆的反应性和反应途径强烈依赖于羰基化合物的结构和静电性质。