4-hydroxypentanoic acid dodecyl amide | 885096-15-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-hydroxypentanoic acid dodecyl amide
• 英文别名: N-dodecyl-4-hydroxypentanamide
• CAS: 885096-15-1
• 化学式: C₁₇H₃₅NO₂
• 分子量: 285.47
• InChiKey: WJNZAZOGXDLPRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-hydroxypentanoic acid dodecyl amide 、 氯甲酸正辛酯 在 吡啶 作用下， 以79%的产率得到(4-dodecylaminocarbonylbut-2-yl) octyl carbonate
  参考文献：
  名称：

  Synthesis and transdermal penetration-enhancing activity of carbonic and carbamic acid esters—Comparison with transkarbam 12

  摘要：

  Transkarbam 12 (T12) is a novel transdermal penetration enhancer with high activity. Its polar head group is formed by carbamic acid salt that is unstable in acidic environment and releases CO2 To find out whether this property influences its high activity, two series of compounds with CO2 stronger bound in the polar head have been prepared-carbonic and carbamic acid esters. The carbamate salt in the polar head was found to be essential for the enhancing activity and its decomposition in an acidic environment suggested relating to the mode of action of T12. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.086
• 作为产物：
  描述：

  delta-戊内酯 、 十二烷基伯胺 以 正己烷 为溶剂， 以76%的产率得到4-hydroxypentanoic acid dodecyl amide
  参考文献：
  名称：

  N-alkylcarbamylalkanol sulfate or salt thereof, process for producing

  摘要：

  一种由下述通式（1-1）表示的N-烷基氨基甲醇磺酸盐或其盐，以及其制备方法和含有该物质的洗涤剂组合物，该物质可用作洗发水、身体或餐具的洗涤剂，不仅具有优异的起泡性和去污力，而且具有高度安全性：##STR1## 其中R.sup.1代表具有6至22个碳原子的线性或支链烷基或烯基基团；R.sup.2代表具有1至22个碳原子的烷基或烯基基团或氢原子；R.sup.3代表具有1至5个碳原子的线性或支链烷基基团；R.sup.4O代表具有2或3个碳原子的氧烷基基团；Ma代表氢原子、碱金属原子、铵基等；n代表0至20之间的数值。

  公开号：

  US05599483A1

文献信息

• N-alkylcarbamylalkanol sulfate or salt thereof, process for producing the same and detergent composition containing the same
  申请人：KAO CORPORATION

  公开号：EP0621265A1

  公开（公告）日：1994-10-26

  A N-alkylcarbamylalkanol sulfate or a salt thereof represented by the following general formula (1-1), a process for producing the same, and a detergent composition containing the same, which is useful as a detergent for hair, body or tableware and has not only excellent foaming power and detergency but also high safety: wherein R¹ represents a linear or branched alkyl or alkenyl group having 6 to 22 carbon atoms; R² represents an alkyl or alkenyl group having 1 to 22 carbon atoms or a hydrogen atom: R³ represents a linear or branched alkylene group having 1 to 5 carbon atoms; R⁴O represents an oxyalkylene group having 2 or 3 carbon atoms; Ma represents a hydrogen atom, an alkali metal atom, an ammonium group, etc.; and n represents a number between 0 and 20).

  一种由以下通式（1-1）表示的 N-烷基氨基甲酰基烷醇硫酸盐或其盐，一种生产该物质的工艺，以及一种含有该物质的洗涤剂组合物，它可用作头发、身体或餐具的洗涤剂，不仅具有出色的发泡力和去污力，而且安全性高： 其中 R¹ 代表具有 6 至 22 个碳原子的直链或支链烷基或烯基；R² 代表具有 1 至 22 个碳原子的烷基或烯基或氢原子：R³ 代表具有 1 至 5 个碳原子的直链或支链亚烷基；R⁴O 代表具有 2 或 3 个碳原子的氧亚烷基；Ma 代表氢原子、碱金属原子、铵基团等；n 代表 0 至 20 之间的数字)。
• US5599483A
  申请人：——

  公开号：US5599483A

  公开（公告）日：1997-02-04
• Synthesis and transdermal penetration-enhancing activity of carbonic and carbamic acid esters—Comparison with transkarbam 12
  作者：Jana Klimentová、Alexandr Hrabálek、Kateřina Vávrová、Tomáš Holas、Aleš Kroutil

  DOI：10.1016/j.bmcl.2005.12.086

  日期：2006.4

  Transkarbam 12 (T12) is a novel transdermal penetration enhancer with high activity. Its polar head group is formed by carbamic acid salt that is unstable in acidic environment and releases CO2 To find out whether this property influences its high activity, two series of compounds with CO2 stronger bound in the polar head have been prepared-carbonic and carbamic acid esters. The carbamate salt in the polar head was found to be essential for the enhancing activity and its decomposition in an acidic environment suggested relating to the mode of action of T12. (C) 2006 Elsevier Ltd. All rights reserved.
• N-alkylcarbamylalkanol sulfate or salt thereof, process for producing
  申请人：Kao Corporation

  公开号：US05599483A1

  公开（公告）日：1997-02-04

  A N-alkylcarbamylalkanol sulfate or a salt thereof represented by the following general formula (1-1), a process for producing the same, and a detergent composition containing the same, which is useful as a detergent for hair, body or tableware and has not only excellent foaming power and detergency but also high safety: ##STR1## wherein R.sup.1 represents a linear or branched alkyl or alkenyl group having 6 to 22 carbon atoms; R.sup.2 represents an alkyl or alkenyl group having 1 to 22 carbon atoms or a hydrogen atom: R.sup.3 represents a linear or branched alkylene group having 1 to 5 carbon atoms; R.sup.4 O represents an oxyalkylene group having 2 or 3 carbon atoms; Ma represents a hydrogen atom, an alkali metal atom, an ammonium group, etc.; and n represents a number between 0 and 20.

  一种由下述通式（1-1）表示的N-烷基氨基甲醇磺酸盐或其盐，以及其制备方法和含有该物质的洗涤剂组合物，该物质可用作洗发水、身体或餐具的洗涤剂，不仅具有优异的起泡性和去污力，而且具有高度安全性：##STR1## 其中R.sup.1代表具有6至22个碳原子的线性或支链烷基或烯基基团；R.sup.2代表具有1至22个碳原子的烷基或烯基基团或氢原子；R.sup.3代表具有1至5个碳原子的线性或支链烷基基团；R.sup.4O代表具有2或3个碳原子的氧烷基基团；Ma代表氢原子、碱金属原子、铵基等；n代表0至20之间的数值。