(S)-α-Cyano-3-phenoxybenzyl-2,2-dimethyl-3R-(2,2-dichlorvinyl)-cyclopropan-1R-carboxylat

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-α-Cyano-3-phenoxybenzyl-2,2-dimethyl-3R-(2,2-dichlorvinyl)-cyclopropan-1R-carboxylat
• 英文别名: [(R)-cyano-(3-phenoxyphenyl)methyl] (1R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate
• 化学式: C₂₂H₁₉Cl₂NO₃
• 分子量: 416.304
• InChiKey: KAATUXNTWXVJKI-WSTRIDTPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  59.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Pten Inhibitors
  申请人：Garlich R. Joseph

  公开号：US20070203098A1

  公开（公告）日：2007-08-30

  The therapeutic use of inhibitors of PTEN activity in the treatment of PTEN-mediated diseases, conditions, and injuries is disclosed.

  本文揭示了使用PTEN活性抑制剂治疗PTEN介导的疾病、病况和损伤的治疗方法。
• Promoting axon regeneration in the adult CNS through control of protein translation
  申请人：CHILDREN'S MEDICAL CENTER CORPORATION

  公开号：US10117866B2

  公开（公告）日：2018-11-06

  Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.

  通过以下方法促进病变的成熟中枢神经系统（CNS）神经元的存活或轴突再生：(a) 用治疗有效量的外源蛋白翻译激活剂与神经元接触；(b) 检测结果对神经元存活或轴突再生的促进作用。
• Methods of diagnosing and treating autism spectrum disorders
  申请人：The Regents of the University of California

  公开号：US10941194B2

  公开（公告）日：2021-03-09

  The invention describes a method of diagnosing an individual as having an increased likelihood of having an autism spectrum disorder and in some instances, selecting a therapy. The invention is related to a system or a kit for performing such a method.

  本发明描述了一种诊断个人患自闭症谱系障碍可能性增加的方法，以及在某些情况下选择疗法的方法。本发明涉及一种用于执行这种方法的系统或套件。
• PTEN Inhibitors Treat Neutropenia-Associated Pneumonia
  申请人：Luo Hongbo R.

  公开号：US20110002877A1

  公开（公告）日：2011-01-06

  Neutropenia-associated pneumonia is treated with a therapeutically effective amount of a small-molecule PTEN inhibitor. The method may further include detecting a resultant alleviation of the neutropenia-associated pneumonia, and/or diagnosing the neutropenia-associated pneumonia. The patient may be undergoing anti-cancer chemotherapy and/or radiotherapy, and the methods may further include the step of treating the patient with broad-spectrum antibiotic therapy or granulocyte colony-stimulating factor (G-CSF) therapy.
• PROMOTING AXON RENEGERATION IN THE ADULT CNS THROUGH CONTROL OF PROTEIN TRANSLATION
  申请人：CHILDREN'S MEDICAL CENTER CORPORATION

  公开号：US20140213609A1

  公开（公告）日：2014-07-31

  Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.